Boldt inquiry concludes: False findings in at least 10 studies, but no harm to patients

Ludwigshafen Hospital, via Wikimedia http://bit.ly/Qnt9wS

It has been a while since we heard about Joachim Boldt, the German anesthesiologist whose 90-odd retractions briefly put him at the top of the heap until Yoshitaka Fujii kicked him off earlier this year.

Now, Boldt’s former institution, the Klinikum Ludwigshafen, has released a report on its investigation into the disgraced critical care expert, and the results aren’t pretty. Here’s a press release about the report, in its entirety: Continue reading Boldt inquiry concludes: False findings in at least 10 studies, but no harm to patients

Does anesthesiology have a problem? Final version of report suggests Fujii will take retraction record, with 172

Japanese investigators have concluded that Yoshitaka Fujii, an expert in postoperative nausea and vomiting whose findings drew scrutiny in 2000 but who continued to publish prolifically for a decade after, fabricated his results in at least 172 published studies.

That number nearly doubles that of the current unofficial retraction record holder, Joachim Boldt.

An inquiry by the Japanese Society of Anesthesiologists (JSA) has determined that Fujii, who was fired in February from his post at Toho University, falsified data in 172 of 212 papers published between 1993 and 2011. Investigators said they found no evidence of fraud in three of the papers, but could not determine whether the results reported in the remaining 37 were reliable.

Of the 172 bogus studies, 126 involved randomized controlled trials. Investigators believe this was not a coincidence: Continue reading Does anesthesiology have a problem? Final version of report suggests Fujii will take retraction record, with 172

Report: Fujii faked data in at least 172 papers

A Japanese web site is reporting that Yoshitaka Fujii, a Japanese anesthesiologist suspected of widespread data fabrication, did indeed fake his results in at least 172 published studies.

According to the article, on a site called Jiji Press: Continue reading Report: Fujii faked data in at least 172 papers

Is post-hoc statistical analysis the new fraud detection tool? A new review looks at fraudster Reuben’s work

In the beginning, there was Scott Reuben.

Well, not quite. Reuben, a Massachusetts anesthesiologist who fabricated data and briefly topped our list of most-retracted authors, didn’t invent research fraud, although he did spend six months in federal prison for his crimes. But his case was in no small measure responsible for the birth of this blog, and, well, the rest of human history that followed.

Although Reuben’s retractions are behind him now — his count ends at 22 — and other scientists, including two anesthesiologists, Joachim Boldt and Yoshitaka Fujii, have or likely soon will dramatically eclipsed his mark, a new paper has revisited his publications with an eye toward seeing if they could identify statistical evidence of data manipulation. It’s the same  kind of effort that Ed Yong highlighted as noteworthy about the Dirk Smeesters case, which we covered yesterday and which involved an anonymous statistically inclined whistleblower.

Before we get to whether there was evidence of such manipulation Continue reading Is post-hoc statistical analysis the new fraud detection tool? A new review looks at fraudster Reuben’s work

193 papers could be retracted: Journal consortium issues ultimatum in Fujii case

A group of editors representing nearly two dozen medical journals has issued an ultimatum of sorts to officials at seven Japanese institutions that once employed Yoshitaka Fujii: Validate the papers of the disgraced anesthesiologist or they will be retracted.

Fujii, as we have reported, was fired by Toho University in late February, putatively for failing to obtain ethics approval for a handful of his studies. That much may be true, but the integrity of his data has been in question for more than a decade. At the time of his dismissal, journal editors expressed concern that the university would not pursue an inquiry into Fujii’s data.

Last month, the journal Anaesthesia published a statistical analysis of Fujii’s research bya UK anesthesiologist named John Carlisle which cast serious doubt on the veracity of the studies.

The joint letter forces the question. Continue reading 193 papers could be retracted: Journal consortium issues ultimatum in Fujii case

Update on Fujii: Anesthesia journal finds overwhelming statistical evidence of data fabrication

There’s a bit more this afternoon on the story of Yoshitaka Fujii, the Japanese anesthesiologist accused of fraud and other misconduct that we reported on yesterday.

The British journal Anaesthesia, which has been looking into Fujii’s research record, has posted four articles and editorials about the case and related issues on its website. One in particular is remarkable for its conclusions. Written by a UK anesthesiologist named John Carlisle, the article claims to have analyzed 169 randomized controlled trials that Fujii conducted between 1991 and 2011.

According to the abstract (which we formatted for readability, and which should be online shortly, we’re told): Continue reading Update on Fujii: Anesthesia journal finds overwhelming statistical evidence of data fabrication

Major fraud probe of Japanese anesthesiologist Yoshitaka Fujii may challenge retraction record

We have learned that a widely published Japanese anesthesiologist is under investigation by his university over concerns that he engaged in repeated fraud for decades that has tainted roughly 180 articles—many of which may be retracted as a result.

In a related move, the journal Clinical Therapeutics is retracting papers by the researcher, Yoshitaka Fujii, most recently of Toho University, in Tokyo. Judy Pachella, managing editor of the journal, confirmed the retractions but would not state how many papers were affected. Clinical Therapeutics published 17 articles by Fujii, between 2003 and 2010.

Continue reading Major fraud probe of Japanese anesthesiologist Yoshitaka Fujii may challenge retraction record

Not so fast! Journal retracts paper from Boldt group over author hijinks, more

We knew we hadn’t heard the last of Joachim Boldt, whose nearly 90 retractions make him the putative record holder for a single author in this indistinguished club. But we didn’t expect this:

The European Journal of Anaesthesiology has retracted a paper, “Supplemental oxygen reduces serotonin levels in plasma and platelets during colorectal surgery and reduces postoperative nausea and vomiting,” from Boldt’s former colleagues at the Klinikum Ludwigshafen after determining that the authors were trying to hide their association with the disgraced anesthesiologist.

Continue reading Not so fast! Journal retracts paper from Boldt group over author hijinks, more

Anesthesia journal editor says “if you blow us off, it will be retracted,” and sticks to his word

The Journal of Clinical Anesthesia has retracted a paper by a group of Israeli authors whose study may not have had appropriate ethical approval — or even collected the reported data.

The article, “Accidental venous and dural puncture during epidural analgesia in obese parturients (BMI > 40 kg/m2): three different body positions during insertion,” was published in 2010 by a team from Assaf Harofeh Medical Center, in Zerifin, one of the country’s largest hospitals and an affiliate of Tel Aviv University. Dural puncture is an infrequent but potentially serious complication of labor anesthesia, causing severe headaches and, in rare cases, death if untreated.

According to the retraction notice: Continue reading Anesthesia journal editor says “if you blow us off, it will be retracted,” and sticks to his word

Joachim Boldt retraction tally drops by one, editors say (but record’s still safe)

As the news of Joachim Boldt’s staggering number of retractions leaps from Retraction Watch into the mainstream press, the consortium of journal editors retracting his studies has backtracked ever so slightly, announcing today that one of the 89 studies for which the German anesthesiologist lacked ethics approval in fact had such sanction.

According to the now-16 (Updated 3/7/11, as it is up from 11 several days ago) editors, LÄK-RLP,  the German body investigating the ethics component of the Boldt case: Continue reading Joachim Boldt retraction tally drops by one, editors say (but record’s still safe)