Category: basic life sciences retractions

Gynecologic cancer researcher up to 13 retractions

13277Noriyuki Takai, a gynecologic cancer researcher at Oita University in Japan, has lost another five papers. With a new total of 13, that means he’s now on our leaderboard.

Three of the retractions are from the journal Tumor Biology, one is from the International Journal of Gynecological Cancer, and one from Anticancer Research.

Takai is the first author on all 5 papers.

As has been the case with Takai’s retractions, and there’s evidence that all were felled by issues with figures. In all, according to the retraction notices, “original data were processed inappropriately.” Four end with the following sentence (or some close variation thereof):

Continue reading Gynecologic cancer researcher up to 13 retractions

Gut paper retracted after university review says “figures cannot be validated by original data”

IBDA biologist at Case Western Reserve University School of Medicine in Ohio has retracted a paper from Inflammatory Bowel Diseases after a university review found the figures within it could not be “validated by original data.”

The 2010 paper, “Elevated IL-13Rα2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway,” concerns the elevated expression and role of an inflammatory protein in colon cancer cells.

According to the notice, corresponding author and biologist Alan Levine — who recently received a $3.9 million Avant-Garde Award for HIV/AIDS Research from the National Institute on Drug Abuse — requested the retraction.

Here’s the full notice: Continue reading Gut paper retracted after university review says “figures cannot be validated by original data”

“Data fabrication and manipulation have occurred”: Taste bud paper soured by fraud

The Journal of NeuroscienceA 2013 paper on the neurological impact of flavors has been retracted from The Journal of Neuroscience. The retraction notice offers few details (which is typical for the journal), but a statement sent to us by the last author noted that an investigation at the University of Maryland “determined that data fabrication and manipulation have occurred in this study.”

“Gustatory Stimuli Representing Different Perceptual Qualities Elicit Distinct Patterns of Neuropeptide Secretion from Taste Buds” examined the relationship between flavors and neuropeptides, molecules that send signals to the brain.

Here’s the retraction notice:

Continue reading “Data fabrication and manipulation have occurred”: Taste bud paper soured by fraud

JBC retraction on neuron development marks second for two biologists

JBCTwo biologists have retracted a second paper on the development of neurons, but that’s about all we know.

The 2007 paper from the Journal of Biological Chemistry, “The Interaction of mPar3 with the Ubiquitin Ligase Smurf2 Is Required for the Establishment of Neuronal Polarity,” concerns the role of a protein, mPar3, in neuron development. It has been cited 29 times, according to Thomson Scientific’s Web of Knowledge.

We don’t know why this one was retracted, because JBC (as usual) offered no explanation in its retraction note:

Continue reading JBC retraction on neuron development marks second for two biologists

JCI issues mega-correction for multiple myeloma paper

125-7-coverThe Journal of Clinical Investigation has issued a lengthy correction to a paper about the role of the immune system in the progression and treatment response of multiple myeloma.

The correction changes details from the name of an author to figure legends, and adds entire supplemental figures.

Shortly after the paper’s publication on April 20th, commenters on PubPeer pointed out duplications in multiple figure panels.

Last month, the journal issued an extensive correction note for “Immunosurveillance and therapy of multiple myeloma are CD226 dependent,” which, in part, tries to explain the multiple duplications.

It starts out noting a typo:

Continue reading JCI issues mega-correction for multiple myeloma paper

Two crystallography papers break apart for “trivial errors,” says author

ACBiophysicists in India have retracted two crystallography papers describing protein binding sites following “concerns,” according to one retraction note.

The last author on both papers, however, told us he believed the retractions were the result of “trivial errors.” Although one journal praised him in its retraction note for his “positive engagement,” he said the process left him feeling “disgusted.”

One paper, “Structural Studies on Molecular Interactions between Camel Peptidoglycan Recognition Protein, CPGRP-S, and Peptidoglycan Moieties N-Acetylglucosamine and N-Acetylmuramic Acid,” was withdrawn from the Journal of Biological Chemistry in August 2014.

The second, “Mode of binding of the antithyroid drug propylthiouracil to mammalian haem peroxidases,” was retracted from Acta Crystallographica Section F this month. Here’s the retraction notice: Continue reading Two crystallography papers break apart for “trivial errors,” says author

Cancer Research retraction is fifth for Robert Weinberg; fourth for his former student

13.coverAnother domino has fallen in a chain of retractions for Robert Weinberg, the man who discovered the first tumor-causing gene in humans, along with the first tumor suppressor gene: Cancer Research just retracted a paper of his on some of the molecular steps to metastasis.

The paper, “Concurrent Suppression of Integrin α5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis,” has been cited 70 times, according to Thomson Scientific’s Web of Knowledge. As we have noted before, Weinberg’s papers are frequently highly cited. His bio at the Whitehead Institute bills him as “a pioneer in cancer research.”

Four of Weinberg’s retracted papers — including this latest — share a first author: Scott Valastyan, once a very promising grad student in Weinberg’s lab. 

This retraction, like Valastyan’s others, is linked to his retracted 2009 Cell paper. (That paper was cited 482 times, and there’s even a video from the Cell press office to go with it). Continue reading Cancer Research retraction is fifth for Robert Weinberg; fourth for his former student

Another author withdrawal from JBC earns another opaque notice

Journal of Biological Chemistry1The authors of a 2014 study on the biochemical changes that can encourage the progression of cancer have withdrawn the paper from the Journal of Biological Chemistry.

The post from the JBC – which we’ve noted are rarely helpful – doesn’t provide any details or reason for the withdrawal. As usual, this is all we got:

Continue reading Another author withdrawal from JBC earns another opaque notice

Misidentified genetic sequence causes retraction of pathogen paper one month after publication

Genome Announcements

The author of an article mapping the genome of an infectious bacterium is pulling the paper because — well, it wasn’t the bacterium she thought it was.

Study author Celia Abolnik is retracting her paper in Genome Announcements because it didn’t actually map out the DNA of Mycoplasma meleagridis, a bacterium that typically infects turkeys but has recently been found in chickens.

The trouble was, the sequence for Mycoplasma meleagridis in the National Institute of Health’s DNA database, Genbank, was actually a different variety of bacteria — Mycoplasma gallinaceum, another scourge of poultry.

Here’s the notice for “Complete Genome Sequence of Mycoplasma meleagridis, a Possible Emerging Pathogen in Chickens:”

Continue reading Misidentified genetic sequence causes retraction of pathogen paper one month after publication

Corrections (and one EoC) propagate for distinguished plant biologist, Olivier Voinnet

Olivier Voinnet
Olivier Voinnet

There may be some deeply rooted issues in the work of high-profile plant biologist Olivier Voinnet, biology department research director at ETH in Zurich. Corrections have continued to pile up months after his work was hit with a barrage of criticism on PubPeer. We’ve tracked a total of seven corrections over the past five months (not including the April retraction of a 2004 paper in The Plant Cell). One of the corrected papers also received an Expression of Concern this week.

Collectively, the corrected papers have accumulated more than 1200 citations.

In January, Voinnet said he planned to correct multiple papers, after receiving “an anonymous email.”

One of the recent corrections we found is for a 2003 article in The Plant Journal, “An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus,” which details using proteins from a tomato virus to help alter gene expression. The study has been cited 862 times, according to Thomson Scientific’s Web of Knowledge. Here’s the correction notice, posted June 8:

Continue reading Corrections (and one EoC) propagate for distinguished plant biologist, Olivier Voinnet