Category: biochemistry

PLOS Genetics updates flagged paper with expression of concern

Screen Shot 2015-09-15 at 2.15.29 PM

PLOS Genetics has upgraded a notice on a paper to an expression of concern, raising the count for author chemist Ariel Fernandez to one retracted paper, and three expressions of concern.

The journal published “Protein Under-Wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability” in 2008. In 2013, Fernandez corrected it, claiming that the work was not actually funded by the U.S. National Institutes of Health, as the original paper had said. The paper has been cited 33 times, according to Thomson Scientific’s Web of Knowledge.

Here’s the expression of concern in full, which was published on September 14:

Continue reading PLOS Genetics updates flagged paper with expression of concern

Former UCSF grad student fudged data in two papers

ORIA former graduate student at the University of California, San Francisco “knowingly falsified and/or fabricated” data in two published papers, according to the Office of Research Integrity.

According to a case summary published this morning, Peter Littlefield was working on his PhD, studying the ways that cells respond to external signals, when he published the two problematic papers. He is the first author on the papers; Natalia Jura, whose lab he worked in, is the last on both.

The report’s findings are based on, among other sources, “the respondent’s admission.”

The first paper, “Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations” was published in Science Signaling and has been cited twice, according to Thomson Scientific’s Web of Knowledge.

Three figures in the paper are problematic, says the ORI summary:

Continue reading Former UCSF grad student fudged data in two papers

Trouble with data proves toxic for a pair of toxicology papers

logoA pair of papers about the risks of titanium dioxide nanoparticles that share many of the same authors has been retracted from a toxicology journal following an investigation at Soochow University in China.

Particle and Fibre Toxicology is retracting the papers for problems with the statistical methods and missing data, as well as for sharing figures.

Here’s the note for “Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications:”

Continue reading Trouble with data proves toxic for a pair of toxicology papers

Investigation triggers retraction for biochem paper

PLOS BiologyA paper has been retracted from PLOS Biology for duplicating lanes and incorporating others that “came from an unrelated experiment that had already been published.”

According to the retraction notice, first author Laura Cerchia says that the mistakes came “as a consequence of incorrect incorporation of representative blots.” Cerchia — along with her supervisor, study author Vittorio de Franciscis — “apologizes for this.” None of the other authors were “involved in the preparation of these figures, and there is no concern about the results that they contributed.”

Cerchia maintains that the paper’s conclusions are still valid, but the remaining authors write that the issues undermines their confidence in the results. According to the notice, the retraction is a result of “an institutional inquiry” at the Consiglio Nazionale delle Ricerche (CNR) in Rome, where Cerchia and de Franciscis are both based.

The notice tells the rest of the story:

Continue reading Investigation triggers retraction for biochem paper

Another author withdrawal from JBC earns another opaque notice

Journal of Biological Chemistry1The authors of a 2014 study on the biochemical changes that can encourage the progression of cancer have withdrawn the paper from the Journal of Biological Chemistry.

The post from the JBC – which we’ve noted are rarely helpful – doesn’t provide any details or reason for the withdrawal. As usual, this is all we got:

Continue reading Another author withdrawal from JBC earns another opaque notice

More “unsubstantiated conclusions” partially sink another origin of life paper

OrigLife_ak17A trio of researchers based in Russia is asking to pull another set of figures and a table from a 2008 paper on modeling ATP formation after an investigation found the fourth researcher – the first author on the paper — “falsified or fabricated” the data they reflect.

The paper, in Origins of Life and Evolution of Biospheres, is the second partial retraction from many of the same authors for the same reason. Both journals also issued erratum notices, which read quite similarly. Here’s the latest note:

Continue reading More “unsubstantiated conclusions” partially sink another origin of life paper

Researcher who broke into lab up to nine retractions

bichaw_v053i036.inddKarel Bezouška, a researcher who broke into a lab refrigerator to tamper with an investigation into his work, has nine retractions.

Here’s the retraction notice in Biochemistry for 2010’s “Cooperation between Subunits Is Essential for High-Affinity Binding of N-Acetyl-d-hexosamines to Dimeric Soluble and Dimeric Cellular Forms of Human CD69:” Continue reading Researcher who broke into lab up to nine retractions

Déjà vu: Double pub in the same issue earns a retraction

biomedchromAlways do a careful reading of your galleys, editors.

We imagine readers of Biomedical Chromatography’s special issue, “Reminiscences of Chang Kee Lim,” did some flipping back and forth when they found the same paper published twice.

Here’s the resulting notice for “Determination of 4-hydroxy-2-nonenal in serum by high-performance liquid chromatography with fluorescence detection after pre-column derivatization using 4-(N,N-dimethylaminosulfonyl)-7-hydrazino-2,1,3-benzoxadiazole”:  Continue reading Déjà vu: Double pub in the same issue earns a retraction

Mystery box sinks immunology paper

Screen Shot 2014-06-30 at 12.30.32 PMBiochemical Journal has pulled a 2006 paper for an undisclosed “background subtraction box” in an image – which, if you take a not-particularly-close look at the figure to the right, means somebody added a black rectangle over the control lane.

Here’s the notice: for “Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activity”: Continue reading Mystery box sinks immunology paper

De-coli: Plagiarism leads to retraction of highly cited recombinant protein paper

appliedmicrobioThe authors of a 2005 article on E. coli in Applied Microbiology and Biotechnology have lost the paper because they recombined it from previous work.

The article, titled “Strategies for efficient production of heterologous proteins in Escherichia coli,” came from a pair of biochemical engineers from the Indian Institute of Technology-Delhi, in New Delhi, India.

According to the abstract: Continue reading De-coli: Plagiarism leads to retraction of highly cited recombinant protein paper