Three expressions of concern added to cancer researcher’s notice list

3.coverQuestions about data and conclusions in papers by a cancer researcher at the University of Maryland have led to three expressions of concern in the Journal of Biological Chemistry.

The notices follow four retractions — two for image duplications and two for unknown reasons — for Anil K. Jaiswal. The three papers under notice are all on mechanisms that regulate gene expression; PubPeer commenters have raised questions about some of the figures in the papers.

The expression of concern on all three papers reads, in full:

Continue reading Three expressions of concern added to cancer researcher’s notice list

Science flags immune-boosting paper under investigation

F1.mediumScience magazine has issued an expression of concern for a paper on the discovery of a new immune-boosting protein. The paper’s findings, which received some press coverage when they came out last spring, are now under investigation by Imperial College London.

The expression of concern follows a correction noting a Western blot mix-up. Science Editor in Chief Marcia McNutt told us last month that the mistake resulted from “carelessness” on the part of the authors. But now, an investigation at Imperial College London — where Philip Ashton-Rickardt led the research — is formally looking into the findings.

That investigation is ongoing, according to the expression of concern (signed by McNutt):

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PLOS ONE issues editor’s note over controversial chronic fatigue syndrome research

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After a request for the original data was denied, PLOS ONE editors have flagged a 2012 sub analysis of a controversial clinical trial on chronic fatigue syndrome with an editor’s note.

The editor’s note — which reads like an Expression of Concern — reiterates the journal’s policy that authors make data and materials available upon request, and notes that staff are following up on “concerns” raised about the study.

There have been numerous requests for data from the “PACE” trial, as the clinical trial is known, which the authors say they have refused in order to protect patient confidentiality. On November 13, James Coyne, a psychologist at the University Medical Center, Groningen, submitted a request for the data from the PLOS ONE paper to King’s College London, where some of the authors were based. According to Coyne’s WordPress blog (he also has a blog hosted by PLOS), the journal asked him to let them know if he “had any difficulties obtaining the data.” He did — KCL denied the request last Friday (the whole letter is worth reading):

The university considers that there is a lack of value or serious purpose to your request. The university also considers that there is improper motive behind the request. The university considers that this request has caused and could further cause harassment and distress to staff.

Last author Peter White at Queen Mary University of London, UK, told us the journal had not asked them to release the data, but he would work with PLOS to address any questions:

We understand PLOS One are following up concerns expressed about the article, according to their internal processes. We will be happy to work with them to address any queries they might have regarding the research.

Here’s the editor’s note for “Adaptive Pacing, Cognitive Behaviour Therapy, Graded Exercise, and Specialist Medical Care for Chronic Fatigue Syndrome: A Cost-Effectiveness Analysis,” in full:

Continue reading PLOS ONE issues editor’s note over controversial chronic fatigue syndrome research

Author’s coordination of peer review flags 13 math papers

home_cover (3)Thirteen papers in Mathematics and Mechanics of Solids now have an expression of concern, after it came to light that an author on most of the papers coordinated the peer-review process.

David Y. Gao, a well-known and prolific mathematician at the Federation University Australia, is the author of 11 of the papers, and also the guest editor of the special issue in which they were set to appear. The papers were published online earlier this year.

A spokesperson for SAGE, which publishes the journal, confirmed that the publisher decided to re-review the papers after learning about Gao’s role in the peer-review process:

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Journal reviewing papers by researcher who sexually assaulted disabled author

Screen Shot 2015-11-03 at 12.10.00 PMA disability journal is “paying significant attention” to papers authored by Anna Stubblefield, a former Rutgers researcher recently convicted of sexually assaulting a disabled man who participated in her research.

Stubblefield was convicted of sexually assaulting “DJ,” a man in his thirties with cerebral palsy who was “declared by the state to have the mental capacity of a toddler,” according to a lengthy piece in the New York Times. Stubblefield and DJ published papers in Disability Studies Quarterly; in one, Stubblefield describes a controversial technique which she claimed helped DJ communicate. But when she eventually used the technique to say DJ was in love with her, his family took her to court, and she was convicted of aggravated sexual assault.

Here is the note from Disability Studies Quarterly, which was published this morningContinue reading Journal reviewing papers by researcher who sexually assaulted disabled author

PLOS Genetics updates flagged paper with expression of concern

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PLOS Genetics has upgraded a notice on a paper to an expression of concern, raising the count for author chemist Ariel Fernandez to one retracted paper, and three expressions of concern.

The journal published “Protein Under-Wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability” in 2008. In 2013, Fernandez corrected it, claiming that the work was not actually funded by the U.S. National Institutes of Health, as the original paper had said. The paper has been cited 33 times, according to Thomson Scientific’s Web of Knowledge.

Here’s the expression of concern in full, which was published on September 14:

Continue reading PLOS Genetics updates flagged paper with expression of concern

Duke researcher with 7 retractions earns two Expressions of Concern

American Journal of Respiratory and Critical Care MedicineData issues continue to plague pulmonary papers co-authored by Duke University professor William Foster and former Duke researcher Erin Potts-Kant. Yesterday, the American Journal of Respiratory and Critical Care Medicine posted an Expression of Concern for two articles from the pair while the findings are “under review.”

The notice was published after the paper’s corresponding author, John Hollingsworth (also at Duke), told the journal that “some of the data published in these articles may be unreliable,” a term that we’ve gotten used to seeing from previous retractions.

Another Expression of Concern from the journal published earlier this year for another paper co-authored by Foster and Potts-Kant turned into a retraction months later. Hollingsworth was a co-author on that paper and another paper retracted from Environmental Health Perspectives in July.

Continue reading Duke researcher with 7 retractions earns two Expressions of Concern

Judge dismisses defamation suit against diabetes journal

Mario Saad, via unicamp.br
Mario Saad, via unicamp.br

Mario Saad can’t catch a break — yesterday, a Massachusetts judge dismissed his defamation suit against the American Diabetes Association, publisher of Diabetes, which published an expression of concern regarding four of his papers in March.

The researcher has tried — and failed — to use the courts to remove the EoC.

In Saad’s latest attempt to employ legal action against the journal — arguing the EoC was defamatory — the United States District Court of Massachusetts was clear in its ruling (which you can view in its entirety here):

Continue reading Judge dismisses defamation suit against diabetes journal

Canadian researchers in legal battle over investigation object to third retraction

The Journal of Clinical InvestigationA third retraction — and a notice of concern — have emerged from the investigation into a husband and wife research team at the University of Toronto that found evidence of faked images and duplicated data.

The problem, according to the latest retraction note for Sylvia Asa and Shereen Ezzat, in the Journal of Clinical Investigation: Portions of the RT-PCR gels “are duplicated in this publication and in a subsequent publication.” That subsequent publication is a 2003 paper that has received a Notice of Concern from the American Journal of Pathology.

According to the retraction note, co-author Gillian E. Wu of York University signed off on the journal’s decision, but Asa, Ezzat and second author Lei Zheng dissented to the retraction. Third author Xian-Feng Zhu couldn’t be reached. Although corresponding author Asa noted that “the initial screen of these samples support the conclusions made in the paper,” the JCI made its position perfectly clear in the note:

Continue reading Canadian researchers in legal battle over investigation object to third retraction

“Significant overlap” between figures spurs note of concern for 13-year-old retinoblastoma paper

AmJPatholThe American Journal of Pathology has posted a note of concern to a 2002 paper about retinoblastoma after discovering two sets of figures “share significant overlap… suggesting that they did not originate from different specimens.”

The overlap was “simultaneously brought to the attention of the Editors” by both the corresponding author and a “concerned reader.”

The paper examined the role of a transcription factor called NF-kappaB in driving retinoblastoma, and suggested that inhibiting the molecule’s activity could be a therapeutic strategy.

The authors attribute the overlap to “an inadvertent misidentification of the original files at the stage of image capture.” They add that they “sincerely regret this inadvertent error;” because other data in the paper show “concordant results,” they stand by the paper’s findings.

Here’s the note:

Continue reading “Significant overlap” between figures spurs note of concern for 13-year-old retinoblastoma paper