Category: cell press

Former UCSF grad student fudged data in two papers

ORIA former graduate student at the University of California, San Francisco “knowingly falsified and/or fabricated” data in two published papers, according to the Office of Research Integrity.

According to a case summary published this morning, Peter Littlefield was working on his PhD, studying the ways that cells respond to external signals, when he published the two problematic papers. He is the first author on the papers; Natalia Jura, whose lab he worked in, is the last on both.

The report’s findings are based on, among other sources, “the respondent’s admission.”

The first paper, “Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations” was published in Science Signaling and has been cited twice, according to Thomson Scientific’s Web of Knowledge.

Three figures in the paper are problematic, says the ORI summary:

Continue reading Former UCSF grad student fudged data in two papers

A correction to a correction for stem cell researcher Jacob Hanna

Jacob Hanna
Jacob Hanna

A correction to a correction is the latest problem for highly cited researcher Jacob Hanna. The stem cell scientist — whose high-profile work has received scrutiny over the past year — has amended an earlier correction notice after a reader spotted an inadvertent “mistake.”

We reported on the original correction, to the 2009 Cell Stem Cell paper “Metastable Pluripotent States in NOD-Mouse-Derived ESCs,” in July. The paper has been cited 184 times, according to Thomson Scientific’s Web of Knowledge.

Apparently, a pair of images in the original correction note are of the same cell colonies, when they are supposed to be of separate cell colonies.

The new (and detailed) note explains how that happened:

Continue reading A correction to a correction for stem cell researcher Jacob Hanna

Brandeis investigation finds scientific misconduct in gold nanoparticle paper

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A group of authors is retracting a paper from Structure following a Brandeis University investigation that found the first author had fabricated a key result.

Former graduate student Kelsey Anthony was first author of the paper, “High-Affinity Gold Nanoparticle Pin to Label and Localize Histidine-Tagged Protein in Macromolecular Assemblies, which was published online in February 2014. At the time, the Science at Brandeis blog noted: Continue reading Brandeis investigation finds scientific misconduct in gold nanoparticle paper

Plague or anthrax on the subway? Think again, says now-corrected study

Cell SystemsAuthors of a widely covered study that documented traces of plague and anthrax on surfaces across New York City have revised the paper after public health officials challenged their interpretations of the data.

It’s hard to overestimate the attention these findings received when first published.

“Bubonic plague found in NYC subway,” wrote The Daily Beast.

“Your subway seat mate: Bubonic plague, anthrax, & mysterious DNA,” said Yahoo!

“NY subway has bubonic plague,” declared Newser.

Not so fast. In an erratum published July 29, the authors write: Continue reading Plague or anthrax on the subway? Think again, says now-corrected study

Inquiry into duplications reveals “multiple” image problems in tumor study

STEM_17_1.c1.inddA paper on how abnormal stem cells can cause benign bone tumors has been retracted by Cell Stem Cell after an inquiry into image duplications also uncovered “multiple instances of inappropriate western blot image adjustment.”

The first two authors “declined” to sign the retraction, according to the notice.

Besides confirming initial suspicions that images had been duplicated, the editors also found “multiple instances of inappropriate western blot image adjustment, such as uneven compression of images and removal of background elements:”

Continue reading Inquiry into duplications reveals “multiple” image problems in tumor study

Cell biologist Hanna issues two errata; images mysteriously disappear from Imgur

Jacob Hanna
Jacob Hanna

Cell biologist Jacob Hanna, the highly cited stem cell researcher currently at the Weizmann Institute of Science,  has posted a long erratum for a 2005 paper in Blood for “inadvertent mistakes,” among other issues; soon after, Hanna’s team issued another erratum for a 2009 Cell Stem Cell paper.

There’s more to tell: Last month, commenters on PubPeer noticed that images from at least 10 of the research papers Hanna coauthored in seven journals — that commenters had posted on the image hosting website Imgur and linked to on PubPeer — had been deleted.

Imgur did not confirm whether these specific images had been deleted, but told Retraction Watch:

Continue reading Cell biologist Hanna issues two errata; images mysteriously disappear from Imgur

Harvard biofilm paper in Cell breaks down after challenged findings can’t be repeated

CELL_161_4.inddResearchers at Harvard have retracted a Cell paper on biofilm disassembly after they repeated the experiment—following contradictory results from another team—and the new results “can no longer support” the original conclusions.

The 2012 paper, “A Self-Produced Trigger for Biofilm Disassembly that Targets Exopolysaccharide,” describes a factor called norspermidine, produced by the bacteria Bacillus subtilis, that appeared to break down biofilms. The researchers used it to prevent biofilm formation of B. subtilis, Escherichia coli, and Staphylococcus aureus. The paper was cited 72 times, according to Thomson Scientific’s Web of Knowledge.

Two years after it was published, a team from University of Texas Southwestern Medical Center in Dallas and the University of Dundee in the UK contradicted the findings in another Cell publication, “Norspermidine Is Not a Self-Produced Trigger for Biofilm Disassembly.” This time, the authors concluded that norspermidine is not present in B. subtilis biofilms, and actually promotes, rather than breaks down, biofilms. They wrote: Continue reading Harvard biofilm paper in Cell breaks down after challenged findings can’t be repeated

Authors retract leptin paper due to “fabricated data”

CellPress_ak2The authors of a study on the effects of the hormone leptin on the liver have retracted it from Cell Metabolism, almost four months after the Office of Research Integrity (ORI) determined it contained faked data, courtesy of its first author.

However, the authors say that the paper’s conclusions remain valid, and are supported by new experiments and additional research by outside groups.

Here’s more from the retraction notice: Continue reading Authors retract leptin paper due to “fabricated data”

Cancer Cell issues big correction over “incorrectly cropped” figures, other issues

cancer cell A 2014 Cancer Cell paper became the subject of an erratum in January 2015, shortly after PubPeer members began criticizing the data. However, many issues brought up by commenters weren’t addressed in the correction notice, including a figure that might be two experiments spliced together to look like one.

The paper, led by Guido Franzoso at Imperial College London, claims that a new cancer drug called DTP3 kills myeloma cells “without causing any toxic side effects,” according to a press release from the school. Guido Franzoso is the founder of Kesios Therapeutics, a drug company which is set to begin clinical trials on DTP3.

The correction indicates that Western blots were cropped badly, which omitted several panels discussed in the text, while an “extra time point” was included accidentally. An antibody was also omitted from the description of the procedure.

PubPeer commenters have noticed additional issues, such as a criticism of figure 3D, which were not included or changed in this correction.

Here’s the correction for “Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors”: Continue reading Cancer Cell issues big correction over “incorrectly cropped” figures, other issues

Cabbage batch skids: new experiments dry up plant paper

current biologyProminent plant researcher Mark Estelle has retracted a paper on plant hormones after follow-up studies showed the conclusions were incorrect.

The hormone in question, auxin, is a major player in plant growth and development. The retracted Current Biology paper reported that a certain auxin receptor, designated AFB4, downregulates the responses of cabbage-cousin Arabidopsis thaliana to the signaling molecule. But after publication, the researchers experimented with a mutant seedling that didn’t produce the receptor, and discovered it didn’t overreact to auxin signals, indicating the receptor wasn’t playing a major role in limiting the effects.

Estelle, a Howard Hughes Medical Institute investigator based at the University of California, San Diego, told us he and his team are working on a paper that will contain the accurate data from the paper, along with new findings.

Here’s the notice for “The AFB4 Auxin Receptor Is a Negative Regulator of Auxin Signaling in Seedlings”, which has 62 citations, per Google Scholar: Continue reading Cabbage batch skids: new experiments dry up plant paper