Category: AAAS

Science journal flags cancer paper under investigation for image manipulation

Science Signaling has issued an expression of concern for a 2016 paper, citing an institutional investigation into image manipulation.

According to a spokesperson for the journal, the corresponding author, Tanya Kalin, became concerned that two images in the paper had been manipulated. Kalin then notified the research integrity officer at Cincinnati Children’s Hospital Medical Center, where she is based.

On May 9 2017, Kalin alerted the journal to the investigation. A week later, the hospital’s research integrity officer followed up with the journal, flagging the figures under question.  The journal then prepared an expression of concern (EOC) to alert readers to the issues and the institution’s investigation.  

Here’s the EOC notice for “The transcription factor FOXF1 promotes prostate cancer by stimulating the mitogen-activated protein kinase ERK5:” Continue reading Science journal flags cancer paper under investigation for image manipulation

“Data had been manipulated:” Science Translational Medicine retracts paper

Science Translational Medicine has retracted a paper by researchers based in Switzerland, after an investigation concluded two figures had been manipulated.

The investigation occurred at the University of Basel. It’s not clear what prompted it, but the paper has been discussed at length on PubPeer. After the investigation concluded two figure panels included manipulated data, the last author asked to retract the paper.

Here’s the notice:

Continue reading “Data had been manipulated:” Science Translational Medicine retracts paper

Updated: Science fish-microplastics paper retracted

Despite continuing to vigorously defend their work, the authors of a controversial paper about the effects of human pollution asked Science to retract the paper last week.

According to a release from Uppsala University issued today, authors Peter Eklöv and Oona Lönnstedt submitted their request to Science last week, noting they wanted to withdraw the paper “as long as a suspicion of misconduct remains.”

The release — which echoes a statement that was also provided to Nature — notes:

Continue reading Updated: Science fish-microplastics paper retracted

“Remarkable” it was ever accepted, says report: Science to retract study on fish and microplastics

Science is retracting a paper about how human pollution is harming fish, after months of questions about the validity of the data.

The move, first reported by the news side of Science on Friday, follows a new report from a review board in Sweden that concluded the authors were guilty of “scientific dishonesty,” and the paper should be “recalled.”

The report had some strong words for the journal and the university that conducted a preliminary investigation:

Continue reading “Remarkable” it was ever accepted, says report: Science to retract study on fish and microplastics

Headline-grabbing Science paper questioned by critics

When zoologists at the University of Oxford published findings in Science last year suggesting ducklings can learn to identify shapes and colors without training (unlike other animals), the news media was entranced.

However, critics of the study have published a pair of papers questioning the findings, saying the data likely stem from chance alone. Still, the critics told us they don’t believe the findings should be retracted.

If a duckling is shown an image, can it pick out another from a set that has the same shape or color?  Antone Martinho III and Alex Kacelnik say yes. In one experiment, 32 out of 47 ducklings preferred pairs of shapes they were originally shown. In the second experiment, 45 out of 66 ducklings preferred the original color. The findings caught the attention of many media outlets, including the New York Times, The Atlantic, and BuzzFeed.

Martinho told us:

Continue reading Headline-grabbing Science paper questioned by critics

High-profile Science paper retracted for misconduct

Science has retracted a high-profile immunology paper after a probe concluded the corresponding author had committed misconduct.

The paper — which initially caught media attention for suggesting a protein could help boost the immune system’s ability to fight off tumors — has been under a cloud of suspicion since last year, when the journal tagged it with an expression of concern, citing a university investigation.

That investigation — at Imperial College London — has concluded that the paper contained problematic figures that were the result of research misconduct. All were prepared by last and corresponding author Philip Ashton-Rickardt, who took full responsibility. Even though the paper was published in 2015, some original blots and accompanying details have disappeared.

Today, the journal released a retraction notice: Continue reading High-profile Science paper retracted for misconduct

Stolen data prompts Science to flag debated study of fish and plastics

scienceIn August, Science told us it was considering adding an Expression of Concern to a high-profile paper about how human pollution is harming fish — and yesterday, the journal did it.

The move comes after a group of researchers alleged the paper contains missing data, and the authors followed a problematic methodology. In September, however, the co-authors’ institution, Uppsala University in Sweden, concluded there wasn’t enough evidence to launch a misconduct investigation.

The notice from Science stems from the theft of a computer carrying some of the paper’s raw data, making it impossible to reproduce some of its findings: Continue reading Stolen data prompts Science to flag debated study of fish and plastics

Eighth Voinnet paper retracted — this one from Science

Olivier Voinnet
Olivier Voinnet

A high-profile plant scientist who has been racking up corrections and retractions at a steady clip has had another paper — this one from Science — retracted.

The retraction, of a paper that had been previously corrected, is the eighth for Olivier Voinnet. According to the notice, the correction did not address all the figure problems with the paper, which “cannot be considered the result of mistakes.”

Here’s the notice in full: Continue reading Eighth Voinnet paper retracted — this one from Science

Inquiry finds no evidence of misconduct in high-profile Science paper flagged by allegations

scienceAn expert group at Uppsala University has recommended not proceeding with a full investigation into allegations of misconduct in a high-profile Science paper showing how human pollution may be harming fish.

The June paper — which caught the media’s attention for suggesting fish larvae are eating small particles of plastic rather than their natural prey — became the focus of scrutiny soon after it was published when a group of researchers raised allegations of misconduct. Earlier this year, Science told us it was considering issuing an Expression of Concern (EOC) for the paper, and Uppsala said it was conducting an inquiry, the first step in determining whether to launch a formal investigation.

The expert group who conducted the preliminary investigation has ultimately recommended against an investigation of the paper, according to an Uppsala spokesperson: Continue reading Inquiry finds no evidence of misconduct in high-profile Science paper flagged by allegations

Widely used brain tumor cell line may not be what researchers thought it was

Bengt Westermark
Bengt Westermark

Nearly 50 years ago, researchers in Uppsala, Sweden used cells from a patient to establish a brain tumor cell line that has become widely used. But a new study suggests that the most common source of that cell line used by scientists today may not be derived from that original patient’s tumor, raising questions about the results obtained in hundreds of studies.

In a new paper out today in Science Translational Medicine, Bengt Westermark, of Uppsala University, and colleagues describe what they found when they performed a forensic DNA analysis comparing the widely used version of the cell line to the original. The findings are consistent with those of other analyses in which cell lines turn out not to be what researchers thought, a problem we’ve focused some attention on.

Here’s an email interview with Westermark about the findings and their implications: Continue reading Widely used brain tumor cell line may not be what researchers thought it was