Category: AAAS

Former UCSD prof who resigned amid investigation into China ties has paper flagged for using the wrong test

Kang Zhang

Science Translational Medicine has issued an expression of concern about a 2020 paper on the genetics of colorectal cancer by a group in China whose results were pegged on a test that couldn’t have produced the findings. 

The article, “Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer,” appeared in January, with authors from both academia and an outfit called the Guangzhou Youze Biological Pharmaceutical Technology Company. 

Continue reading Former UCSD prof who resigned amid investigation into China ties has paper flagged for using the wrong test

Indiana University paper about lung transplantation retracted after misconduct finding

After a finding of data manipulation, the corresponding author of a 2014 paper by a team of researchers at Indiana University has retracted the work.

Here’s the notice in Science Translational Medicine: Continue reading Indiana University paper about lung transplantation retracted after misconduct finding

Science retracts paper after Nobel laureate’s lab can’t replicate results

Science is retracting a 2014 paper from the lab of a Nobel winner after replication attempts failed to conclusively support the original results.

In January, Bruce Beutler, an immunologist at University of Texas Southwestern Medical Center and winner of the 2011 Nobel Prize in Physiology or Medicine, emailed Science editor-in-chief Jeremy Berg to report that attempts to replicate the findings in “MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses” had weakened his confidence in original results. The paper had found that virus-like elements in the human genome play an important role in the immune system’s response to pathogens.

Although Beutler and several co-authors requested retraction right off the bat, the journal discovered that two co-authors disagreed, which Berg told us drew out the retraction process. In an attempt to resolve the situation, the journal waited for Beutler’s lab to perform another replication attempt. Those findings were inconclusive and the dissenting authors continued to push back against retraction.

Berg told us:

Continue reading Science retracts paper after Nobel laureate’s lab can’t replicate results

Science journal flags cancer paper under investigation for image manipulation

Science Signaling has issued an expression of concern for a 2016 paper, citing an institutional investigation into image manipulation.

According to a spokesperson for the journal, the corresponding author, Tanya Kalin, became concerned that two images in the paper had been manipulated. Kalin then notified the research integrity officer at Cincinnati Children’s Hospital Medical Center, where she is based.

On May 9 2017, Kalin alerted the journal to the investigation. A week later, the hospital’s research integrity officer followed up with the journal, flagging the figures under question.  The journal then prepared an expression of concern (EOC) to alert readers to the issues and the institution’s investigation.  

Here’s the EOC notice for “The transcription factor FOXF1 promotes prostate cancer by stimulating the mitogen-activated protein kinase ERK5:” Continue reading Science journal flags cancer paper under investigation for image manipulation

“Data had been manipulated:” Science Translational Medicine retracts paper

Science Translational Medicine has retracted a paper by researchers based in Switzerland, after an investigation concluded two figures had been manipulated.

The investigation occurred at the University of Basel. It’s not clear what prompted it, but the paper has been discussed at length on PubPeer. After the investigation concluded two figure panels included manipulated data, the last author asked to retract the paper.

Here’s the notice:

Continue reading “Data had been manipulated:” Science Translational Medicine retracts paper

Updated: Science fish-microplastics paper retracted

Despite continuing to vigorously defend their work, the authors of a controversial paper about the effects of human pollution asked Science to retract the paper last week.

According to a release from Uppsala University issued today, authors Peter Eklöv and Oona Lönnstedt submitted their request to Science last week, noting they wanted to withdraw the paper “as long as a suspicion of misconduct remains.”

The release — which echoes a statement that was also provided to Nature — notes:

Continue reading Updated: Science fish-microplastics paper retracted

“Remarkable” it was ever accepted, says report: Science to retract study on fish and microplastics

Science is retracting a paper about how human pollution is harming fish, after months of questions about the validity of the data.

The move, first reported by the news side of Science on Friday, follows a new report from a review board in Sweden that concluded the authors were guilty of “scientific dishonesty,” and the paper should be “recalled.”

The report had some strong words for the journal and the university that conducted a preliminary investigation:

Continue reading “Remarkable” it was ever accepted, says report: Science to retract study on fish and microplastics

Headline-grabbing Science paper questioned by critics

When zoologists at the University of Oxford published findings in Science last year suggesting ducklings can learn to identify shapes and colors without training (unlike other animals), the news media was entranced.

However, critics of the study have published a pair of papers questioning the findings, saying the data likely stem from chance alone. Still, the critics told us they don’t believe the findings should be retracted.

If a duckling is shown an image, can it pick out another from a set that has the same shape or color?  Antone Martinho III and Alex Kacelnik say yes. In one experiment, 32 out of 47 ducklings preferred pairs of shapes they were originally shown. In the second experiment, 45 out of 66 ducklings preferred the original color. The findings caught the attention of many media outlets, including the New York Times, The Atlantic, and BuzzFeed.

Martinho told us:

Continue reading Headline-grabbing Science paper questioned by critics

High-profile Science paper retracted for misconduct

Science has retracted a high-profile immunology paper after a probe concluded the corresponding author had committed misconduct.

The paper — which initially caught media attention for suggesting a protein could help boost the immune system’s ability to fight off tumors — has been under a cloud of suspicion since last year, when the journal tagged it with an expression of concern, citing a university investigation.

That investigation — at Imperial College London — has concluded that the paper contained problematic figures that were the result of research misconduct. All were prepared by last and corresponding author Philip Ashton-Rickardt, who took full responsibility. Even though the paper was published in 2015, some original blots and accompanying details have disappeared.

Today, the journal released a retraction notice: Continue reading High-profile Science paper retracted for misconduct

Stolen data prompts Science to flag debated study of fish and plastics

scienceIn August, Science told us it was considering adding an Expression of Concern to a high-profile paper about how human pollution is harming fish — and yesterday, the journal did it.

The move comes after a group of researchers alleged the paper contains missing data, and the authors followed a problematic methodology. In September, however, the co-authors’ institution, Uppsala University in Sweden, concluded there wasn’t enough evidence to launch a misconduct investigation.

The notice from Science stems from the theft of a computer carrying some of the paper’s raw data, making it impossible to reproduce some of its findings: Continue reading Stolen data prompts Science to flag debated study of fish and plastics