Following an investigation into an October 2009 study in Science that claimed to have proven the ability of a device to measure all of the enzyme activity in a cell at a particular time, the journal has asked the study’s authors to retract the paper, Science‘s news blog, ScienceInsider, reported on Friday.
The move comes after Bruce Alberts, Science‘s editor in chief, issued an Editorial Expression of Concern in December in response to concerns raised by other scientists
to alert our readers to thefact that serious questions have been raised about the methodsand data presented in this article. The questions focus in particularon the synthesis of the dye-labeled metabolites that are centralto the microarray technique. In addition, the spectroscopicdata the authors cite in support of their claim were not postedto the Bangor University School of Biological Sciences Web siteat the time of publication, despite the authors’ indicationin the Supporting Online Material that the data would be soposted. In response to inquiries from Science, the authors haveprovided new descriptions of the synthetic methods that differsubstantially from those in their published article. Based onour original concerns and the authors’ response, Science hasrequested evaluation of the original data and records by officialsat the authors’ institutions: These officials have agreed toundertake this task.
That evaluation, reported late last month by Nature, concluded Continue reading Science wants “reactome array” enzyme chip authors to retract paper
