Category: pnas retractions

Nobel Prize winner Gregg Semenza retracts four papers

Gregg Semenza

A Johns Hopkins researcher who shared the 2019 Nobel Prize in Medicine or Physiology has retracted four papers from the Proceedings of the National Academy of Sciences (PNAS) for concerns about images in the articles.

Gregg Semenza is “one of today’s preeminent researchers on the molecular mechanisms of oxygen regulation,” the work for which he shared the 2019 Nobel, according to Hopkins. But even before that, the pseudonymous Claire Francis began pointing out potential image duplications and other manipulations in Semenza’s work on PubPeer, as described in October 2020 by Leonid Schneider.

The four papers retracted yesterday are:

Continue reading Nobel Prize winner Gregg Semenza retracts four papers

PNAS retracts paper that contributed to lung cancer trial

National Cerebral and Cardiovascular Center

A paper that was the subject of a four-page correction in 2018, and which helped inform a now-halted clinical trial of a drug for lung cancer, has been retracted following an institutional investigation concluded that one of the researchers had falsified the data in that article and at least four others. 

And we have learned that Springer Nature should be acting on a different article by the researcher shortly, and has just begun an investigation of yet another.

The PNAS article, which appeared in 2015, was written by Takashi Nojiri, formerly of Osaka University and the National Cerebral and Cardiovascular Center Research Institute, in Japan. As we reported in June, an August 2020 report from National University Corporation Osaka University and National Cerebral and Cardiovascular Center Hospital concluded that Nojiri committed: 

Continue reading PNAS retracts paper that contributed to lung cancer trial

Leading marine ecologist, now White House official, violated prominent journal’s policies in handling now-retracted paper

Jane Lubchenco

A marine ecologist at Oregon State University now helping lead the Biden White House’s climate and environmental initiatives violated the conflict of interest policy at the Proceedings of the National Academy of Sciences when she edited a paper in the journal last year.

Jane Lubchenco, who served as administrator of the National Oceanic and Atmospheric Administration from 2009 to 2013 under President Obama, joined the White House in March of this year as Deputy Director for Climate and Environment in the Office of Science and Technology Policy.

Last year, while still at Oregon State, Lubchenco, a member of the National Academy of Sciences, was the handling editor for an article titled “A global network of marine protected areas for food,” by Reniel Cabral and Steven Gaines of the University of California, Santa Barbara, and colleagues. Such marine protected areas, aka MPAs, have come under scrutiny, as Yale’s E360 noted in 2019:

Continue reading Leading marine ecologist, now White House official, violated prominent journal’s policies in handling now-retracted paper

Highly criticized paper on dishonesty retracted

Dan Ariely

The Proceedings of the National Academy of Sciences (PNAS) has retracted a highly influential 2012 paper by Dan Ariely, a behavioral economist at Duke University whose work has been called into question over concerns about the data in some of his publications.

The retraction wasn’t unexpected. Ariely and his colleagues said last month that they would be pulling the article, “Signing at the beginning makes ethics salient and decreases dishonest self-reports in comparison to signing at the end,” in the wake of revelations that some of the data in the study appear to have been fabricated. 

As Stephanie Lee of BuzzFeed reported in August:

Continue reading Highly criticized paper on dishonesty retracted

Authors of study on race and police killings ask for its retraction, citing “continued misuse” in the media

via Tony Webster/Flickr

The authors of a controversial paper on race and police shootings say they are retracting the article, which became a flashpoint in the debate over killings by police, and now amid protests following the murder of George Floyd.

[See an update on this post.]

The 2019 article in the Proceedings of the National Academy of Sciences (PNAS), titled “Officer characteristics and racial disparities in fatal officer-involved shootings,” found “no evidence of anti-Black or anti-Hispanic disparities across shootings, and White officers are not more likely to shoot minority civilians than non-White officers.” It has been cited 14 times, according to Clarivate Analytics’ Web of Science, earning it a “hot paper” designation.

Joseph Cesario, a researcher at Michigan State University, told Retraction Watch that he and David Johnson, of the University of Maryland, College Park and a co-author, have submitted a request for retraction to PNAS. In the request, they write:

Continue reading Authors of study on race and police killings ask for its retraction, citing “continued misuse” in the media

Former UCSD prof who resigned amid investigation into China ties retracts paper for ‘inadvertently misidentified’ images

Kang Zhang

Kang Zhang, a formerly high-profile geneticist at the University of California, San Diego, who resigned his post last July amidst an investigation into undisclosed ties to China, has retracted a paper because some of its images were taken from other researchers’ work.

The paper, “Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging,” was submitted to the Proceedings of the National Academy of Sciences (PNAS) last fall, months after Zhang’s resignation. One of Zhang’s fellow corresponding authors, Jian-Kang Zhu, used the journal’s “Contributed Submissions” process, in which “An NAS member may contribute up to two of her or his own manuscripts for publication in PNAS each year.”

PNAS published the paper on February 6 of this year. But on February 18, authors of a different paper, in Aging Cell, sent the editors of PNAS a letter, writing:

Continue reading Former UCSD prof who resigned amid investigation into China ties retracts paper for ‘inadvertently misidentified’ images

Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Title: A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins

What Caught Our Attention: Here’s a cut-and-paste issue that gave us pause. The authors of an 18-year-old paper in PNAS corrected it after realizing some bands in a figure were duplicated (an issue raised on PubPeer one year ago). It turns out, the first author had cut the paper into pieces and reassembled them to present the blots in the “desired order,” and some had become duplicated by mistake. The overall results were unaffected, so the journal swapped the image with a corrected version. Continue reading Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Caught Our Notice: Voinnet co-author issues another correction

Title: AtsPLA2-α nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response

What Caught Our Attention:  A previous collaborator with high-profile plant biologist Olivier Voinnet (who now has eight retractions) has issued an interesting correction to a 2010 PNAS paper. Susana Rivas is last author on the paper, the correction for which notes some images were duplicated, and others were “cropped and/or stretched to match the other blots.” Rivas is currently a group leader at The Laboratory of Plant-Microbe Interactions (LIPM), “a combined INRA-CNRS Research Unit.” Continue reading Caught Our Notice: Voinnet co-author issues another correction

Overlooked virus “generated a mess,” infected highly cited Cell, PNAS papers

When Alexander Harms arrived at the University of Copenhagen in August 2016, as a postdoc planning to study a type of antibiotic resistance in bacteria, he carried with him a warning from another lab who had recruited him:

People said, “If you go there, you have to deal with these weird articles that nobody believes.”

The papers in question had been published in the Proceedings of the National Academy of Sciences in 2011 and Cell in 2013. Led by Kenn Gerdes, Harms’s new lab director, the work laid out a complex chain of events that mapped out how an E. coli bacterium can go into a dormant state, called persistence, that allows it to survive while the rest of its colony is wiped out.

Despite some experts’ skepticism, each paper had been cited hundreds of times. And Harms told us:

I personally did believe in the published work. There had been papers from others that kind of attacked [the Gerdes lab’s theory], but that was not high-quality work.

But by November 2016, Harms figured out that the skeptics had been right.  Continue reading Overlooked virus “generated a mess,” infected highly cited Cell, PNAS papers

Florida investigation can’t ID culprit who falsified data in retracted PNAS paper

When the Proceedings of the National Academy of Sciences retracted a gene therapy paper in December, it declared that some of the data had been falsified and mentioned a research misconduct investigation. But the notice said nothing about who was responsible.

Via a public records request, Retraction Watch has obtained investigation documents from the University of Florida, which show the focus had been narrowed down to two of the paper’s three co-first authors. But the investigation committee didn’t assign blame to either one. According to their final report, dated Oct. 24, 2016:

there was not enough direct evidence to either implicate or exonerate either of these individuals.

Over the course of the formal investigation, which lasted from early August to late October 2016,  the committee was able to determine that data in the PNAS paper had been falsified. However, it said: Continue reading Florida investigation can’t ID culprit who falsified data in retracted PNAS paper