Author: Andrew P. Han

Given “wrong pathology slides,” heart journal retracts paper

A cardiology journal has retracted a paper after the authors were unable to provide correct pathology slides to replace the wrong ones submitted with the original manuscript.

The paper is titled “Aortic Valve Endocarditis and Coronary Angiography With Cerebral Embolic Protection,” published on April 10, 2017 in The Journal of the American College of Cardiology: Cardiovascular Interventions (JACC:CI). It has not yet been cited, according to Clarivate Analytics’ Web of Science.

JACC:CI retracted the paper on Aug. 14, providing this notice: Continue reading Given “wrong pathology slides,” heart journal retracts paper

Genetic disorder gets name change, but patient’s father still not happy

Credit: Online Mendelian Inheritance in Man

The leading genetic disease database has chosen a new name for a genetic condition, following complaints from a man whose son has the condition.

On Aug. 11, 2017, two days after our coverage of the situation, the Online Mendelian Inheritance in Man (OMIM) database changed the primary name of the phenotype associated with mutations in the RPS23 gene. The new name describes a set of features: “Brachycephaly, Trichomegaly, and Developmental Delay,” or BTDD.

Brachycephaly describes a condition where the back of the head is abnormally flat and trichomegaly refers to extra length, curling, pigmentation, or thickness of the eyelashes.

Marc Pieterse, of the Netherlands, has a son with the rare RPS23 mutation, one of two known patients in the world. The mutation affects ribosomes, cell components involved in protein production. On Aug. 9, we reported on Pieterse’s crusade against OMIM’s original name for the condition, which dubbed it a syndrome. He has feared that calling it a syndrome would “stigmatize” his son’s condition and tried to get the paper underpinning the OMIM entry retracted. The American Journal of Human Genetics has said it will not retract the paper.

Continue reading Genetic disorder gets name change, but patient’s father still not happy

Researcher who shot dean after being fired for misconduct sentenced to 28 years in prison

Hengjun Chao. Credit: Westchester County DA

A former researcher at Mount Sinai’s medical school has been sentenced to 28 years in prison for shooting the dean that fired him.

On the morning of Aug. 29, 2016, Chao, 50, attacked Dennis Charney, dean of the Icahn School of Medicine at Mount Sinai, with a shotgun outside a deli in suburban New York. In 2010, Charney fired Chao for scientific misconduct. Charney survived the shot, but was hospitalized for five days.

As reported by the Chappaqua-Mount Kisco Patch yesterday, Judge Barry Warhit sentenced Hengjun Chao to 23 years, each, for attempted murder and assault, to be served concurrently; the maximum sentence for the attempted murder charge that Chao faced was 25 years. The judge also sentenced Chao to the maximum for criminal use of a firearm — five years — which will be served consecutively, bringing the total to 28 years.

In June, a New York jury found him guilty of attempted murder and the two other felony charges.

Stewart Orden, Chao’s defense attorney, told Retraction Watch he was “shocked at the sentence:” Continue reading Researcher who shot dean after being fired for misconduct sentenced to 28 years in prison

Unearthed emails: Monsanto connected to campaign to retract GMO paper

A trove of internal documents from Monsanto, recently unsealed in a lawsuit against the agricultural biotech giant, has revealed the firm’s role in the knotty tale of a paper from the lab of a scientist known for his stance against genetically modified organisms (GMOs).

That paper is “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize,” published in September 2012 in the journal Food and Chemical Toxicology (FCT) and retracted in January 2014. Gilles Seralini, a scientist known for an adversarial stance towards GMOs, was first author. The documents have also spurred the retraction of several pro-GMO articles on Forbes.com written by Henry Miller, a fellow at the Hoover Institution, a conservative think tank at Stanford University. Emails showed that one of the articles, which didn’t discuss Seralini’s paper, was ghostwritten by Monsanto.

The documents, posted last week by the law firm of Baum, Hedlund, Aristei and Goldman, show Monsanto engaged with a network of scientists and other commentators to spread the message that the Seralini paper was bad science and should be retracted. Seralini told Retraction Watch that this proves what he has been saying all along, that Monsanto led a concentrated effort to discredit his science and protect its bottom line. He said:

Continue reading Unearthed emails: Monsanto connected to campaign to retract GMO paper

Fearing “stigmatization,” patient’s father seeks retraction of paper on rare genetic mutation

The father of a boy with a rare genetic mutation has accused a scientist of exploiting his child by proclaiming the defect a “genetic syndrome” and naming it after herself.

At an impasse with scientists investigating, publicizing, and interpreting his son’s condition, the father seems willing to use any leverage he can muster to remove the “syndrome” entry in an online genetic disease database. Based solely on an email he obtained from the database director, the father became convinced that if the paper underpinning the entry were retracted, the syndrome would go down with it. So earlier this year, he withdrew his consent and asked the journal that published the paper for a retraction, based on improper patient consent. He has also threatened to lob accusations of research misconduct at the paper’s last author. Continue reading Fearing “stigmatization,” patient’s father seeks retraction of paper on rare genetic mutation

“Right to be forgotten” takes down BMJ’s 15-year-old film review

A subject in a documentary film about the psychology of religious ideation has pushed the BMJ to take down its review of the film, based on a complaint citing a European internet privacy rule.

On July 3, BMJ posted a retraction notice for an article that barely said anything:

This article has been retracted by the journal following a complaint.

The 2002 article is a review of a documentary film entitled “Those Who Are Jesus,” directed by Steven Eastwood, a British filmmaker. The review has been removed from the BMJ site, as well as PubMed.   

BMJ told Retraction Watch that it took down the film review in response to a European citizen exercising his or her “right to be forgotten,” an internet privacy idea that, according to the European Union, ensures:

Continue reading “Right to be forgotten” takes down BMJ’s 15-year-old film review

Toronto wife-husband research team lose bid to re-open labs

Shereen Ezzat. Source: University Health Network
Sylvia Asa. Source: University of Toronto

A pair of Canadian scientists may be running out of options to save their laboratories, which have been permanently closed based on findings of research misconduct.

Sylvia Asa, once the head of the largest hospital diagnostic laboratory in Canada, and her husband and collaborator Shereen Ezzat, have spent almost five years fighting allegations of research misconduct involving data falsification and fabrication in more than a dozen published papers. The couple’s work has been scrutinized by their employer, University Health Network (UHN), a healthcare system affiliated with the University of Toronto, in two investigations. The investigations did not find evidence that Asa or Ezzat were directly involved in image falsification or fabrication; however, they concluded that, as supervisors, they failed to conform to accepted standards and practices as they related to scientific rigor and accountability.

After the first investigation, UHN decided to temporarily close both Asa and Ezzat’s labs. After the second, the UHN decided to make that closure permanent. The couple have had three papers retracted and at least one correction.

Recently, the pair faced yet another setback. After they asked an Ontario court to review two of UHN’s decisions, on July 13, a judge found no fault with either one. Justice Ian Nordheimer, one of three judges who considered Asa and Ezzat’s request, said in his written opinion:  Continue reading Toronto wife-husband research team lose bid to re-open labs

Controversial CRISPR paper earns second editorial note

Against the authors’ objections, Nature Methods has added an expression of concern to a 2017 paper that drew fire for suggesting a common gene editing technique could cause widespread collateral damage to the genome. The latest note — the second to be added in two months — alerts readers to an alternative interpretation of the findings.

When “Unexpected mutations after CRISPR–Cas9 editing in vivo” was published May 30, it immediately drew criticism from many of the top scientists working with CRISPR, including those associated with companies seeking to develop CRISPR-based therapies for humans. Share prices for the two largest companies pursuing CRISPR therapies, Editas Medicine and Intellia Therapeutics, dropped following publication of the article.

On June 14, the journal published a notice to alert readers to “technical criticisms” of the paper. Apparently, that wasn’t sufficient, because the journal is now providing more details on the nature of the criticisms, despite the objections of the paper’s authors:

Continue reading Controversial CRISPR paper earns second editorial note

Drip, drip: UCLA investigation finds more image duplications

Image duplications and unsupported data continue to plague a network of cancer researchers that includes the former vice chancellor for research at the University of California, Los Angeles, James Economou.

On July 2, the editors at Cancer Research retracted a 2011 paper that Economou published as last author, saying it suffered from image duplication and unsupported figures. This is the second retraction we’re aware of to come out of an investigation by UCLA’s Office of Research Policy and Compliance that has touched this group of scientists.

Here’s the notice for “Molecular Mechanism of MART-1+/A*0201+ Human Melanoma Resistance to Specific CTL-Killing Despite Functional Tumor–CTL Interaction,” which says the retraction comes at the request of UCLA: Continue reading Drip, drip: UCLA investigation finds more image duplications

Ex-Wayne State scientist, ORI square off in court

WASHINGTON, D.C — Last week, former brain scientist Christian Kreipke stared down the third set of research misconduct allegations against him since 2011. Or, possibly, according to him, it was the third iteration of the same research misconduct allegations he’s faced for years, a piling on by the most powerful of the three institutions out to ruin him after he allegedly uncovered a grant fraud scheme at Wayne State University, his former employer.

All the same, over three days Kreipke faced off against the U.S. Office of Research Integrity in a virtual administrative law courtroom as he contested a finding of research misconduct and an accompanying 10-year ban on receiving federal funding. In Washington, prosecutor Patricia Mantoan, a U.S. Department of Health and Human Services (HHS) attorney representing the ORI, brought the government’s case against him, wrapping up well before the end of Monday, July 10. Onlookers at the public hearing watched on video monitors as Kriepke sweated, literally, through hours of testimony, much of it with him on the witness stand. Despite being confined to what his lawyer, Shereef Akeel, of Detroit-area firm Akeel & Valentine called an “85 degree” room at the U.S. District Court in Detroit, Kreipke’s defense team took their time laying out his side of the story.

Since the allegations were first raised, Kreipke’s defense has remained largely the same: the misconduct allegations from Wayne State, brought in 2011, are retaliation against him for raising doubts the year before about accounting practices related to federal grants. At trial, Akeel characterized Wayne State’s misconduct investigation as a “witch hunt” that was out to get Kreipke, no matter what. Continue reading Ex-Wayne State scientist, ORI square off in court