According to the authors’ institution, IMIM in Barcelona, all co-authors are aware of the retraction. The penultimate author — Antonio García de Herreros — retracted three papers in May from the Journal of Biological Chemistry for reusing images to represent different experiments, and recently corrected multiple figures in a Journal of Cell Science paper over “possible duplications and/or splices.”
Here’s the newest retraction notice:
This article has been retracted at the request of the authors.
We, the authors, are retracting this article because of inappropriate manipulation of the data in the H3K4me3 blot in the left panel of Figure 3C (LOXL2). Specifically, a duplicated/inverted lane 3 replaced the original lane 1. Readers raised concerns about data presented in Figures 1, 3, and 4. We provided all of the raw data corresponding to these figures to Molecular Cell and the Scientific Integrity Committee of our institute, the IMIM (Hospital del Mar Medical Research Institute). The journal and the Scientific Integrity Committee of the IMIM found several issues, but determined that apart from the instance in Figure 3C, there was no evidence of intentional misconduct. However, because the data in the H3K4me3 blot in the left (LOXL2) panel of Figure 3C were inappropriately manipulated, resulting in a figure that does not accurately represent the data as obtained, we are retracting the paper. We wish to note that other experimental replicates reproduced the result in the H3K4me3 blot in Figure 3C’s left (LOXL2) panel. In addition, our subsequent papers showing that oxidation of H3 by LOXL2 has a central role in EMT (Millanes-Romero et al., Mol. Cell 2013) and that LOXL2 oxidizes methylated TAF10 (Iturbide et al., Mol. Cell 2015) support the central findings of this paper. We apologize to the scientific community for any inconveniences resulting from the publication and retraction of this manuscript.
The 2012 paper, “Lysyl Oxidase-like 2 Deaminates Lysine 4 in Histone H3,” has so far been cited 46 times, according to Thomson Reuters Web of Science.
Rafael de la Torre Fornell, director of the Hospital del Mar Medical Research Institute (IMIM) in Barcelona, Spain, told us:
The editor of the journal contacted us several months ago and asked our institution to perform an inquiry on comments appeared in PubPeer regarding the article concerned. We performed an internal inquiry and an external expert was also requested to review those aspects of the manuscript under examination. We prepared a report with all materials collected that was submitted to the journal. On that basis, decisions were taken by the editorial board of the journal and elements of the report are present in the retraction of the manuscript.
Here’s the PubPeer thread to which Fornell referred.
The senior author takes full responsibility of the manuscript. All authors are aware that the notice of the retraction has been issued. The Commission on Scientific Integrity of our institute will meet the next days and this retraction case will be reviewed and it will discussed if any corrective active action has to be taken.
When we reported on the case earlier this month, Fornell told us:
We are aware of retractions concerning Dr. Antonio Garcia-Herreros work. Internally this issue is managed by our Good Scientific Practices and Scientific Misconduct Committee. We are expecting the report of the committee to proceed with corrective actions.
We’ve reached out to Peiró, and will update the post with anything else we learn.
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