Category: clinical study retractions

Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study

A sweeping analysis of more than 5,000 papers in eight leading medical journals has found compelling evidence of suspect data in roughly 2% of randomized controlled clinical trials in those journals.

Although the analysis, by John Carlisle, an anesthetist in the United Kingdom, could not determine whether the concerning data were tainted by misconduct or sloppiness, it suggests that editors of the journals have some investigating to do. Of the 98 studies identified by the method, only 16 have already been retracted. [See update at end.]

The types of studies analyzed — randomized controlled clinical trials — are considered the gold standard of medical evidence, and tend to be the basis for drug approvals and changes in clinical practice. Carlisle, according to an editorial by John Loadsman and Tim McCulloch accompanying the new study published today in Anesthesia, Continue reading Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study

Journal retracts Ohio State CrossFit study at center of lawsuits

The fallout continues for a study conducted at a local CrossFit gym by researchers at The Ohio State University. First it was corrected, now it’s been retracted, and it continues to be the basis of litigation against both the authors and the publisher.

Editors at the Journal of Strength and Conditioning Research have decided to pull the 2013 study after learning that the research protocol had not been approved by Ohio State’s institutional review board (IRB).

Over the past few years, the study has spawned several lawsuits, including a defamation suit brought by gym owner Mitch Potterf against Ohio State that landed him a six-figure settlement, as well as an ongoing suit by Potterf against the National Strength and Conditioning Association (NSCA, which publishes the journal). The CrossFit brand has also sued the NSCA. [See update at end of post for more on that case.]

An NSCA statement issued May 30 describes what happened: Continue reading Journal retracts Ohio State CrossFit study at center of lawsuits

NEJM issues unusual warning for readers about 1980 letter on opioid addiction

This week, the New England Journal of Medicine issued a type of editor’s note we’ve never seen before, on a highly influential letter published nearly 40 years ago.

Above the one-paragraph letter, which reports data suggesting pain medications are not likely to cause addiction, the journal has added a note warning readers that the letter has been “heavily and uncritically cited” by sources using it to suggest opioids are not addictive.

In essence, the journal isn’t commenting on the merits of the letter — the problem is how it’s been used by others.

The same issue of the journal includes a letter by researchers based in Canada who analyzed how the 1980 letter had been cited, noting:

Continue reading NEJM issues unusual warning for readers about 1980 letter on opioid addiction

Yikes: Peer reviewer stole (and published) author’s data

A gastroenterology and hepatology journal has retracted a 2017 review after discovering it included data “accessible only during peer review for another journal.”

Although we don’t know the details of this particular case—for instance, how the editors and publisher of Alimentary Pharmacology & Therapeutics learned about the transgression and which author was responsible—the journal acted quickly to retract the paper, which was published online in March.

Here’s the retraction notice for “Systematic review: benefits and harms of transarterial embolisation for treating hepatocellular adenoma:”

Continue reading Yikes: Peer reviewer stole (and published) author’s data

Drug researcher up to ten retractions

A pharmaceutical researcher has received his tenth retraction. The reason, once again: duplicating his previous work.

Giuseppe Derosa, based at the University of Pavia in Italy, lost a 2011 paper this month after journal editors identified “substantial duplication of an earlier published paper.” According to the notice, the authors failed to cite the previous work and to disclose that the manuscript had been published or was under consideration elsewhere.

Derosa has a habit of reusing clinical trial data in multiple papers. He received his first four retractions in 2015 for publishing the same clinical trial results six times—two of those papers were retracted over the summer and two more several months later. By 2016, a fifth from the bunch was retracted (one of the six still stands). Derosa received another retraction, citing duplication (which we covered here and which was not related to the six clinical trials).

Continue reading Drug researcher up to ten retractions

BMJ journal yanks paper on cancer screening in India for fear of legal action

BMJ Global Health has pulled a paper that criticized U.S. research of the effects of cervical cancer screening in India over defamation concerns.

That’s not what the notice on the paper says, however — at the moment, it just reads:

This article has been withdrawn.

However, forwarded email correspondence between the first author and an associate publisher reveals the journal published the paper and planned a press release, then realized it should be reviewed by a legal adviser. When first author Eric J. Suba at Kaiser Permanente San Francisco Medical Center inquired about the status of the paper and any potential press release, he was told the journal could no longer publish it, out of concern they would be taken to court.

Suba told us that, when he learned the paper would be pulled:

Continue reading BMJ journal yanks paper on cancer screening in India for fear of legal action

Reuters removes story on gender confirmation surgery because firm mistakenly released data

Reuters has removed a story about gender confirmation surgery, saying it included problematic data.

The public relations firm representing the American Society of Plastic Surgeons (ASPS) — which generated the data in the report  — took responsibility, saying it supplied Reuters with data the ASPS did not want released.

Yesterday, Reuters pulled its version of a widely-reported story about an increase in such surgeries in the U.S. (Later, it pulled the withdrawal notice as well, only to make it reappear at a different URL.)

The story, originally posted just after midnight yesterday, reported a 19 percent increase in those procedures from 2015 to 2016, based on data provided the American Society of Plastic Surgeons (ASPS). Around 1 pm US Eastern time that day, Reuters put up a withdrawal notice in place of the original story:

Continue reading Reuters removes story on gender confirmation surgery because firm mistakenly released data

Researchers mistakenly administer three-fold higher dose of anesthesia

Researchers have retracted a 2016 paper after discovering that they accidentally administered three times the reported dose of anesthesia to rats.

In the Experimental Physiology paper, the authors set out to mathematically map how rats’ blood pressure changes under different conditions, which required the rats to be anesthetized. But their findings were called into question when they found the rats had received a much higher concentration of anesthesia than intended. According to the notice, this higher dose compromised the “objectives of the experiment.”

The corresponding author Karol Ondrias, from the Institute of Molecular Physiology and Genetics at the Slovak Academy of Sciences in Bratislava, told us how the dosing error occurred: Continue reading Researchers mistakenly administer three-fold higher dose of anesthesia

Journal flags two more papers by diabetes researcher who sued to stop retractions (and now has 12)

A diabetes journal has issued two notices of concern for papers co-authored by a researcher who took another publisher to court after it did the same thing — but ultimately lost.

The notices are for two papers co-authored by Mario Saad — who, after losing his legal battle with the American Diabetes Association, has since accumulated 12 retractions. Both notices — from the journal Diabetologia, published by Springer and the the European Association for the Study of Diabetes (EASD) — say they have alerted Saad to their concerns about some of the images in the papers, and the university where he is based was asked to investigate more than one year ago. Since the journal has not yet received any information from the University of Campinas in Brazil, however, it decided to issue expressions of concern for the two papers.

Here’s the text of the first notice:

Continue reading Journal flags two more papers by diabetes researcher who sued to stop retractions (and now has 12)

Gender-based violence researcher now up to 10 retractions for plagiarism

A publisher has retracted all of the papers it published by a researcher in Nigeria, citing plagiarism.

The papers, all about terrorism and gender-based violence, were written by Oluwaseun Bamidele. The journal editors and the publisher, Taylor & Francis, decided to retract nine papers by Bamidele because of the overlap to other works — which he also failed to reference.

Bamidele — who also lost a paper on Boko Haram for the same reason — told us he didn’t learn about what constitutes plagiarism until his graduate studies, after he’d already written the now-retracted manuscripts:

Continue reading Gender-based violence researcher now up to 10 retractions for plagiarism