Category: immunology retractions

“Carelessness” forces Science to correct paper about immune booster

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Science is fixing images in a paper published online in April that discovered an immune-boosting protein, after the authors mistakenly mixed up similar-looking Western blots.

The paper, which received some press coverage, identified a protein that helped the immune system fight off cancers and infections. Philip Ashton-Rickardt, a scientist at Imperial College London who led the study, told the The Telegraph:

This is exciting because we have found a completely different way to use the immune system to fight cancer.

The editor in chief of Science, Marcia McNutt, told us that the journal contacted the authors once it learned of “irregularities” in some of the figures, which did not affect the conclusions of the paper:

Chronic fatigue syndrome-XMRV researcher scheduled to head to court today, alleging conspiracy

Judy Mikovits
Judy Mikovits

Chronic fatigue syndrome researcher Judy Mikovits was scheduled to head is heading to court today, where a California judge will would decide whether or not to dismiss her lawsuit against fourteen people and two Nevada corporations.

(Note: This story has been updated. See below.)

Among the defendants: the Whittemore Peterson Institute  in Reno, Nevada where Mikovits used to work; the institute’s cofounders, Annette and Harvey Whittemore; a colleague with whom she shares a retracted Science paper; and several members of California and Nevada law enforcement.

The complaint does not check the box next to “Money Demanded in Complaint”, but also lists $750,000 in the associated field:

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In 2006, Mikovits began working for the Whittmores at the WPI; her job was to search for a biological cause of chronic fatigue, a vexing, mysterious disease afflicting their daughter. Part of her research focused on a potential link between chronic fatigue syndrome and a virus known as XMRV. But after others — and Mikovits herself — couldn’t replicate results published in Science and the paper was retracted, she was fired from her position in 2011. Mikovits alleges that Continue reading Chronic fatigue syndrome-XMRV researcher scheduled to head to court today, alleging conspiracy

Plagiarism was “not an intentional act,” says first author of retracted TB paper

logoA 2013 review article about tuberculosis is being retracted for “unacknowledged re-use of significant portions of text” from another article, which the first author said wasn’t intentional.

Sayantan Ray, based at Medical College and Hospital, Kolkata in India, told us that “most of the unchanged text” is present in sections written by junior co-authors. Since there doesn’t appear to be any attempt to cover it up, he argued anyone responsible for the plagiarism must not have realized it was wrong:

You can appreciate that this type of obvious similarity can only happen when the concerned person [does] not have any idea about [the] plagiarism issue.

According to the notice, published by Therapeutics and Clinical Risk Management, most of the re-used text appears to have come from a 2012 paper in the Indian Journal of Medical Research. Here’s more from the notice:

Continue reading Plagiarism was “not an intentional act,” says first author of retracted TB paper

“Insufficient permission” from funder resects liver disease paper

HepatologyA study on chronic liver inflammation was pulled from the journal Hepatology because of “insufficient permission by the authors’ funding institution to submit and publish the manuscript.” 

The paper, which was published in July, looked into how steatosis, the abnormal retention of fat in the liver, turns into steatohepatitis, also known as fatty liver disease. Researchers found that Treg cells play a central role in controlling the disease.

Unfortunately, the journal’s managing editor didn’t provide any information about the nature of the permission problems, and the notice doesn’t give any details.

Here it is, in full:

Continue reading “Insufficient permission” from funder resects liver disease paper

Author objects to retraction for not “faithfully represented” immunology figures

The Journal of ImmunologyAll but one of the authors of a study about the immune response to H. pylori have agreed to a retraction in The Journal of Immunology, due to two of the paper’s figures not being “faithfully represented.”

Authors of the 2006 paper said they were unable to provide the original unedited scans “due to inadequate archiving dating back almost 10 years.” The authors — with the exception of the first author, Sushil Kumar Pathak, apologized for the error.

The notice, which has been appended to the pdf, reads:

Continue reading Author objects to retraction for not “faithfully represented” immunology figures

“Rigging of the peer-review process” kills parasite paper

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A paper on nematode parasites appears to have been infected with a nasty strain of a publishing problem known as fake peer review. By our count, the phenomenon has felled approximately 250 papers in total.

The affected review, “The important role of matrix metalloproteinases in nematode parasites,” explores a type of enzyme secreted by the parasite. Published in Helminthologia, it’s been cited once, according to Thomson Scientific’s Web of Knowledge.

Unfortunately, the retraction note doesn’t give us too many details about how the peer review process was manipulated:

Continue reading “Rigging of the peer-review process” kills parasite paper

Authors withdraw immunology study, no reasons given

Journal of Biological Chemistry1Researchers have withdrawn a 2010 article in the Journal of Biological Chemistry about an immune regulator.

The paper was pulled without any explanation (in standard JBC style). Here’s the complete notice:

This article has been withdrawn by the authors.

The study’s authors were based out of Shandong University Medical School, Jinan General Hospital of Jinan Command and Duke University Medical Center.

Two of the authors have had previous papers retracted.

Continue reading Authors withdraw immunology study, no reasons given

JCI issues mega-correction for multiple myeloma paper

125-7-coverThe Journal of Clinical Investigation has issued a lengthy correction to a paper about the role of the immune system in the progression and treatment response of multiple myeloma.

The correction changes details from the name of an author to figure legends, and adds entire supplemental figures.

Shortly after the paper’s publication on April 20th, commenters on PubPeer pointed out duplications in multiple figure panels.

Last month, the journal issued an extensive correction note for “Immunosurveillance and therapy of multiple myeloma are CD226 dependent,” which, in part, tries to explain the multiple duplications.

It starts out noting a typo:

Continue reading JCI issues mega-correction for multiple myeloma paper

AIDS vaccine fraudster sentenced to nearly 5 years in prison and to pay back $7 million

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A researcher who confessed to spiking rabbit blood samples to make the results of an HIV vaccine experiment look better has been sentenced to 57 months of prison time, according to The Des Moines Register.

Dong-Pyou Han has also been ordered to repay more than $7 million to the U.S. National Institutes of Health, and will have three years of supervised release following his prison term.

In December, 2013, the U.S. Office of Research Integrity announced that Han, formerly at Iowa State University (ISU), had faked his results to make an HIV vaccine look more powerful. The faulty data made their way into seven national and international symposia between 2010 and 2012 (resulting in a retracted poster in 2014), along with three grant applications and multiple progress reports. Han agreed to a three-year research ban, and resigned from ISU in October the following year.

The NIH never sent the final $1.38 million grant payment of more than $10 million awarded to Han’s boss, Michael Cho, and ISU returned nearly $500,000 it had received for Han’s salary and other costs.

However, Continue reading AIDS vaccine fraudster sentenced to nearly 5 years in prison and to pay back $7 million

Another “first author has accepted responsibility” retraction from immunity journal

IAIScientists have pulled their 2013 Infection and Immunity paper after a reader noticed duplicated data in three figures, and the first author was “unable to provide the original data used to construct the figures,” according to the journal’s editor-in-chief.

According to the retraction note, “the first author has accepted responsibility for these anomalies” — similar to another recent retraction from the same journal, also due to image duplication reported by a reader (apparently the journal has one or more careful readers).

The paper, “Pseudomonas aeruginosa Outer Membrane Vesicles Modulate Host Immune Responses by Targeting the Toll-Like Receptor 4 Signaling Pathway,” concerns the role of outer membrane vesicles excreted by the bacteria to incite an inflammatory response in mice. It was written by authors at the University of North Dakota, Sichuan University in China, and the University of Chicago, and has been cited six times, according to Thomson Scientific’s Web of Knowledge.

Here’s the complete retraction note:

Continue reading Another “first author has accepted responsibility” retraction from immunity journal