Category: cardiovascular research

Heart journal issues expression of concern after fraud report

circulationThe American Heart Association’s journal Circulation has issued an expression of concern for a paper about the molecular underpinnings of arrhythmias that was co-authored by a biomedical engineer who committed fraud on a massive scale.

According to an investigation by the Office of Research Integrity (ORI), former Vanderbilt engineer Igor Dzhura faked nearly 70 images and drastically over-estimated the number of experiments he conducted. He was banned from receiving federal funding for three years.

The fraud has resulted in six retracted papers, Dzhura has agreed to retract six papers, which have been cited more than 500 times. [Ed. note: at this time, only one paper has actually been retracted]

Continue reading Heart journal issues expression of concern after fraud report

Heart journal pulls paper for image manipulation

cardresCardiovascular Research has retracted a 2010 paper by a group of prominent cardiology researchers in Brazil.

The reason: Image manipulation — which the authors say didn’t materially affect the conclusions of the paper.

The article, “FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex,” came from a group led by Ana Paula Dalla Costa, from the State University of Campinas.

Here’s the abstract of the study, which has been cited 19 times, according to Thomson Scientific’s Web of Knowledge: Continue reading Heart journal pulls paper for image manipulation

Heart paper will go on, but only in the first of two journals it was published in

Cardiovascular ResearchA cardiovascular group has retracted a conference proceeding abstract, because it too closely resembled a paper they published prior to the conference.

The last author is baffled as to why the journal couldn’t have made that call before they published the abstract.

Here’s the notice for “Increased beta-adrenergic inotropy in ventricular myocardium from Trpm4 knockout mice”: Continue reading Heart paper will go on, but only in the first of two journals it was published in

More on Hattori case from co-author: Did grudge lead to scientist’s fall?

We have an update on the case of Yoshiyuki Hattori, the Japanese endocrinologist who has had a half-dozen papers retracted because of issues involving reused data. We’ve reported on some of those retractions, and report on three new ones here.

As a trainee, Hattori spent some time in England, where he met Steven Gross, a prominent pharmacology researcher at Cornell. Gross was impressed with the young physician-scientist, and invited him back to his New York City laboratory to do a postdoc.

Gross’ name appears on one of the retracted articles, “NO suppresses while peroxynitrite sustains NF-κB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO,” which appeared in 2004 in the journal Cardiovascular Research and has been cited 42 times, according to Thomson Scientific’s Web of Knowledge.

According to the notice: Continue reading More on Hattori case from co-author: Did grudge lead to scientist’s fall?

Unprecedented? Journal yanks transcendental meditation paper 12 minutes before it’s scheduled to publish

There’s a highly unusual situation brewing at the Archives of Internal Medicine. At 3:48 Eastern time on Monday, 12 minutes before the embargo lifted on the June 28 issue of the Archives of Internal Medicine, the following message went out from its press office:

The editorial office of the Archives of Internal Medicine has made the decision not to publish,  “Stress Reduction in the Secondary Prevention of Cardiovascular Disease: A Randomized Controlled Trial of Transcendental Meditation and Health Education in African Americans,” by Schneider et al, and the accompanying Commentary by Mehta and Bairey Merz that was to post Online First at 3 PM central time today.

The decision is to allow time for review and statistical analysis of additional data not included in the original paper that the authors provided less than 24 hours before posting.  We apologize for the short notice, but hope you will understand and not run your stories on this study today.

We asked Archives of Internal Medicine editor Rita Redberg when the paper might be published: Continue reading Unprecedented? Journal yanks transcendental meditation paper 12 minutes before it’s scheduled to publish

Another retraction of Spirocor research

Remember Spirocor, the Israeli company that closed down a clinical trial involving its “respiratory stress” test for coronary artery disease because the data underpinning the validity of the method proved unreliable? The problem led to the retraction of two articles, about which we’ve previously reported. But we also found a study by some of the same researchers, who include scientists in Israel and the United States, that had been presented at the 2010 meeting of the American Heart Association and published in the journal Circulation.

That abstract, No. 14426 “Accuracy and Usefulness of Finger Pulse Wave Analysis during Brief Deep Breathing Exercise (Respiratory Stress Response) as a Marker of Significant Coronary Artery Disease,” has now been retracted — making, to our knowledge, the entire body of published research on the Spirocor product an editorial memory.

Here’s the notice, which appears within the text of the abstract: Continue reading Another retraction of Spirocor research