Category: basic life sciences retractions

Nature yanks controversial genetics paper whose co-author was found dead in lab in 2012

naturecover1113Nature has retracted a controversial 2012 paper by a group from Johns Hopkins University which has been the subject of a protracted public dispute.

The article, “Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK,” came from the lab of Jef Boeke,  a celebrated biochemist. But a former lab member, Daniel Yuan, who was fired by Hopkins in late 2011 after 10 years at the institution, had repeatedly raised questions about the validity of the findings. Those concerns eventually made their way into the Washington Post, prompting this response from the university. Continue reading Nature yanks controversial genetics paper whose co-author was found dead in lab in 2012

He said, she said: Journal of Neuroscience expresses concern, but doesn’t pursue investigation

j neuroscienceThe Journal of Neuroscience‘s retraction notices often give us plenty to chew on, and a new Expression of Concern does the same.

In the notice — for a 16-year-old paper — the journal notes three cases of what certainly sounds like image manipulation, but carefully avoids calling it that: Continue reading He said, she said: Journal of Neuroscience expresses concern, but doesn’t pursue investigation

Data artifact claims two fruit fly papers from leading UK group — who offer model response

jcbcoverA team of researchers led by Daniel St. Johnston, director of the Gurdon Institute at Cambridge and a prominent developmental biologist in the UK, has lost a pair of articles after finding that their data were unreliable. But rather than “correct” the record with subsequent papers, they’ve withdrawn the problematic work.

To our mind, this is a poster case of doing the right thing by science. We think the notices — as provided by the authors and reported by the journals — pretty much say it all, so we’ll let them speak for themselves, followed by some details St. Johnston shared with us.

The first article, “LKB1 and AMPK maintain epithelial cell polarity under energetic stress,” appeared in 2007 in the Journal of Cell Biology and has been cited 108 times, according to Thomson Scientific’s Web of Knowledge.

According to the retraction notice:

Continue reading Data artifact claims two fruit fly papers from leading UK group — who offer model response

“Not exoneration”: University reverses sanctions on husband-wife team found to have manipulated images

Maria Bravo, via UNAM
Alejandra Bravo, via UNAM

A complicated case involving two microbiology researchers at the National Autonomous University of Mexico (UNAM) appears to have come to some conclusion.

In November of last year, we reported that Continue reading “Not exoneration”: University reverses sanctions on husband-wife team found to have manipulated images

Retraction for stem cell scientist facing misconduct inquiry

scadcoverHere’s a retraction from Stem Cells and Development that we’re just now getting around to covering. The paper, “Non-viral reprogramming of skeletal myoblasts with valproic acid for pluripotency,” appeared in June 2012 in a preliminary online form and was written by a group at the University of Cincinnati. As the retraction notice states: Continue reading Retraction for stem cell scientist facing misconduct inquiry

Fernández genetics paper in limbo over data concerns

annrevgenAriel Fernández, the protein researcher whose theories of drug design lately have come in for questioning, has lost a paper, at least for the moment.

The article, “Supramolecular Evolution of Protein Organization,” appeared online in Annual Reviews of Genetics prior to print. It lists Fernández’s affiliation as ProWD Sciences, in Madison, Wisc. Not much exists on the web about that company, however, except an under-construction site. (ProWD, by the way, is short for PROtein-Water-Dehydron, Fernández’s area of interest.)

Here’s the notice: Continue reading Fernández genetics paper in limbo over data concerns

“Ambiguities in the presentation of some of the data” lead to an ambiguous retraction notice

brainSometimes, authors and journals editors seem to think a bit of mystery is a good thing. Take a recent retraction in Brain.

Here’s the  notice for “Selective impairment of hand mental rotation in patients with focal hand dystonia:” Continue reading “Ambiguities in the presentation of some of the data” lead to an ambiguous retraction notice

Pamela Ronald does the right thing again, retracting a Science paper

Pamela Ronald, via UC Davis
Pamela Ronald, via UC Davis

About a month ago, we reported on a retraction by Pamela Ronald, of the University of California, Davis, and colleagues. We noted then that this was a case of scientists doing the right thing. Ronald contacted us after that post ran, and let us know that there would be another retraction shortly. That retraction notice has now appeared, in Science: Continue reading Pamela Ronald does the right thing again, retracting a Science paper

Embryonic stem cell paper retracted for fabrication

scadcoverStem Cells and Development has retracted a paper it published earlier this year after the leader of the study reported that the data were unreliable.

The paper, “Derivation and Genetic Modification of Embryonic Stem Cells from Disease-Model Inbred Rat Strains,” came from the lab of Aron Geurts, of the Medical College of Wisconsin.

According to the retraction notice: Continue reading Embryonic stem cell paper retracted for fabrication

Aoki notches fourth retraction for image problems

jbc1013We have a fourth retraction in the Journal of Biochemistry for Naohito Aoki, a Japanese researcher and former postdoc in a German lab, whose images have been called into question but whose retraction notices were scant. In this case, however, the journal, while not exactly overbrimming with information about the article, at least gives us some sense of what’s going on.

Aoki worked in the lab of Axel Ullrich, of the Max Planck Institute of Biochemistry, and appeared on two retracted articles in the Journal of Biological Chemistry (JBC) with his mentor, along with a third with a co-author from Japan, Tsukasa Matsuda. Although those notices don’t say anything about the reason for the retractions — this was before the JBC started providing such information — Ulrich told us that Aoki had been manipulating images. Continue reading Aoki notches fourth retraction for image problems