Leading cancer vaccines researcher retracts paper for figure “discrepancies” flagged by watchdog blog

Gerold Schuler, a German immunology researcher who shared the 2006 Deutscher Krebspreis — aka the German Cancer Prize — for his work that contributed to cancer vaccines has retracted a paper in International Immunology following concerns raised by a German science watchdog blog.

Here’s the notice: Continue reading Leading cancer vaccines researcher retracts paper for figure “discrepancies” flagged by watchdog blog

Whistleblower forces retractions of four stem cell papers amid questions about more than a dozen studies

In a case that is a good reminder of why journal editors shouldn’t ignore anonymous tips, a Seoul National University stem cell researcher has been forced to retract four papers, and withdraw another under peer review, in Antioxidants & Redox Signaling following a whistleblower’s exhaustive analysis.

Two retractions by Soo Kyung Kang, a professor of veterinary biotechnology at Seoul National University, appeared on May 9 after an anonymous whistleblower sent a 70-slide PowerPoint presentation to the editors of ten journals that contained evidence of suspicious floating error bars, errors larger than actual measurements, pasted-together lanes in PCR gels and RNA and CHIP blots and several cases where the same control blot data is shown across different experiments and in different papers. In all, the whistleblower raises questions about 14 papers in the ten journals.

Here is the May 9 notice for “Nuclear Ago2/HSP60 contributes to broad spectrum of hATSCs function via Oct4 regulation”: Continue reading Whistleblower forces retractions of four stem cell papers amid questions about more than a dozen studies

Retraction seven for Shouwei Han, this one in the American Journal of Physiology

ShouWei Han, who has been forced to retract six papers from various physiology journals following an investigation into his work by his former employer, the University of Louisville, has added another one to his tally.

Here’s the notice, from the American Journal of Physiology: Lung Cellular and Molecular Physiology: Continue reading Retraction seven for Shouwei Han, this one in the American Journal of Physiology

Group investigated by University of Louisville corrects lung cancer paper after retracting six others

A group of researchers whose work has been under investigation at the University of Louisville has issued a correction for a paper in the American Journal of Respiratory Cell and Molecular Biology (AJRCMB).

The correction follows three retractions each in the Journal of Biological Chemistry and the AJRCMB, the latter of which made it clear that lab member ShouWei Han was responsible for the manipulations and duplications that brought down the papers. Here’s the new notice, which appeared in the March 1, 2012 issue of the journal: Continue reading Group investigated by University of Louisville corrects lung cancer paper after retracting six others

JCO expresses concern over images from Spanish group that had aroused earlier concern

The Journal of Clinical Oncology has issued an expression of concern about a 2003 article by a group of researchers in Spain who appear to have had recurrent problems with images.

The paper has been cited 56 times, according to Thomson Scientific’s Web of Knowledge. Here’s the notice:

It has been brought to our attention, regarding Figure 1, Part A, that similarity exists between bands 3, 4, and 5 of the top row and bands 1, 2, and 3 of the bottom row, including the presence of artifacts, in the April 15, 2003 article by [Jose] RomanGomez et al, entitled, “Cadherin-13, a Mediator of Calcium Dependent Cell-Cell Adhesion, Is Silenced by Methylation in Chronic Myeloid Leukemia and Correlates With Pretreatment Risk Profile and Cytogenetic Response to Interferon Alfa” (J Clin Oncol 21:1472-1479, 2003).  This similarity has raised concerns about whether these rows represent independent data. We alerted the corresponding author, Dr. Roman-Gomez, of this concern, and he has repeated the experiment shown in the original Figure 1, with the results below. Although the results of the figure appear to be unchanged, we wish to inform the readers of this issue, so that they may make their own independent assessment.

Continue reading JCO expresses concern over images from Spanish group that had aroused earlier concern

Can we trust Western blots?

The title of this post is the headline of our latest column for LabTimes. It’s inspired by a number of animated discussions on Retraction Watch following our coverage of various Western blot problems — some unintentional, and some, well, less so.

Take, for example, this comment, which we quote in the column: Continue reading Can we trust Western blots?

Three more retractions for resveratrol researcher Dipak Das, in free radical journals

Das, via UConn

The retraction count for Dipak Das, the resveratrol researcher whom the University of Connecticut found to have committed 145 counts of fabrication and falsification of data, has risen to eight with withdrawals by Free Radical Biology & Medicine and Free Radical Research.

The two Free Radical Biology & Medicine retractions, for “Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol” (cited 38 times, according to Thomson Scientific’s Web of Knowledge) and “Redox regulation of resveratrol-mediated switching of death signal into survival signal” (cited 32 times), are carefully detailed and read the same way: Continue reading Three more retractions for resveratrol researcher Dipak Das, in free radical journals

Cell paper, once plagiarized, pulled for dodgy figures

A while back (last June, to be precise), we wrote about a group of Japanese endocrinologists who found a creative way to up their citation counts using duplicate publication. At the time, the researchers were docked a 2004 paper in the Journal of Steroid Biochemistry & Molecular Biology that had self-plagiarized extensively from a 2003 article in Cell.

Well, skeptics of this new math take heart: The group’s publication total has fallen yet again. Turns out that 2003 paper — which has been cited 160 times, up from 144 when we checked last year, according to Thomson Scientific’s Web of Knowledge — wasn’t quite up to snuff, either.

According to the retraction notice for the article, “The Chromatin-Remodeling Complex WINAC Targets a Nuclear Receptor to Promoters and Is Impaired in Williams Syndrome:” Continue reading Cell paper, once plagiarized, pulled for dodgy figures

Two more retractions in respiratory journal as University of Louisville completes investigation

Last July, we reported on four retractions by a group of researchers at the University of Louisville, and we noted that the scientists’ work was under investigation. That investigation has apparently concluded, according to a retraction notice in the American Journal of Respiratory Cell and Molecular Biology for two of their papers: Continue reading Two more retractions in respiratory journal as University of Louisville completes investigation

ORI: Former SUNY Upstate neuroscience dept. chair Miller manipulated data in four grant applications

Last month, we reported on two retractions by the former neuroscience and physiology department chair at the State University of New York (SUNY) Upstate Medical University in Syracuse. Both of the retractions were requested by the university after an investigation found that Michael W. Miller had committed misconduct.

Now, the Office of Research Integrity (ORI), which reviews misconduct investigations by NIH grantee institutions, has weighed in. As detailed in the Federal Register, ORI found that Miller falsified or fabricated data in four NIH grant applications, the two published (and now retracted) papers, and one manuscript submitted to the Proceedings of the National Academy of Sciences (PNAS). For example, he Continue reading ORI: Former SUNY Upstate neuroscience dept. chair Miller manipulated data in four grant applications