Sebastiani group retracts genetics of aging study from Science

When a group of researchers last year claimed to have found a “genetic signature” to identify people likely to live to 100, they were questioned immediately. Now they’ve retracted the controversial paper —  but continue to stand behind their assertion.

The paper had been the subject of an “Expression of Concern” in November. The retraction notice in this week’s Science: Continue reading Sebastiani group retracts genetics of aging study from Science

Science asks authors to retract XMRV-chronic fatigue syndrome paper; when they refuse, issue Expression of Concern

It’s Expression of Concern Day here at Retraction Watch. Earlier, we reported on two such notices regarding the complicated case of Milena Penkowa. And now we learn that a 2009 Science paper linking XMRV, or xenotropic murine leukemia-related virus, to chronic fatigue syndrome  (CFS) that has been dogged by questions from the start, is the subject of another Expression of Concern. Such expressions, as we’ve noted, often, but do not always, precede retractions.

The Wall Street Journal reports that Science editor-in-chief Bruce Alberts and executive editor Monica Bradford asked the authors of the paper to retract it last week, after two studies scheduled to published in this week’s Science threw even more doubt onto the findings. But “study co-author Judy A. Mikovits of the Whittemore Peterson Institute for Neuro-Immune Disease said “it is premature to retract our paper,” leading Alberts to issue the Expression of Concern, which begins: Continue reading Science asks authors to retract XMRV-chronic fatigue syndrome paper; when they refuse, issue Expression of Concern

Science publishes replication of Marc Hauser study, says results hold up

There has been some news over the past few weeks about Marc Hauser, the Harvard psychologist found guilty of misconduct by the university last year. First, because Harvard had listed him in a course catalog, The Crimson said that he might be teaching again, following a ban. But that turned out not to be the case, as The Boston Globe reported.

Today, Science lifted the embargo on a paper by Hauser and Justin Wood, now of the University of Southern California, showing that results published in the journal in 2007 — and later questioned — have held up. The abstract: Continue reading Science publishes replication of Marc Hauser study, says results hold up

Science plays two — a retraction, and concern issued about genetics papers

It’s a busy week at Science. The journal is retracting a controversial paper about which it had previously expressed doubts, and has published an “Expression of Concern” about another article that looks like it might be headed for the same fate.

First, the retraction.

The move involves an October 2009 paper, on which we’ve previously posted, by European researchers who claimed to have made a major advance in the ability to watch how enzymes behave in cells — thereby giving scientists a new tool for monitoring the function of genes.

But back in December, Science editor Bruce Alberts issued this “Expression of Concern” about the research: Continue reading Science plays two — a retraction, and concern issued about genetics papers

Nobelist Linda Buck retracts two studies on olfactory networks — and the news is embargoed

Well, it’s happened: The Embargo Watch and Retraction Watch worlds have collided. I had initially figured on two posts here, but it soon became clear that how journals were handling these retractions, using embargoes, was central to both. So this is being cross-posted on both blogs.

Linda Buck, who shared the 2004 Nobel Prize in Physiology or Medicine, has retracted two papers published in 2005 and 2006. Both retractions — one in the Proceedings of the National Academy of Sciences (PNAS) and one in Science — appear online today.

The papers describe how nerves that carry information about scents connect from the nose to the olfactory bulb, where they are processed. They were published after the 2004 Nobel, which was for discoveries “of odorant receptors and the organization of the olfactory system.”

The retractions come two and a half years after Buck retracted a 2001 Nature paper co-authored with Zhihua Zou, a post-doc in her then-Harvard lab. She’s been at the Fred Hutchinson Cancer Research Center since 2002, and is a Howard Hughes Medical Institute investigator. In 2008, Nature’s news section reported:

Harvard Medical School has formed an ad hoc committee to review the retraction, and Buck has asked the Fred Hutchinson Cancer Research Center to review two later publications on which Zou was the lead author. “It’s disappointing of course,” says Buck. “The important thing is to correct the literature.”

The PNAS and Science retractions are of those two later publications. The PNAS study was cited 61 times, and the Science study was cited 73 times, according to the Thomson Scientific Web of Knowledge.

The Science retraction reads: Continue reading Nobelist Linda Buck retracts two studies on olfactory networks — and the news is embargoed

Science wants “reactome array” enzyme chip authors to retract paper

Following an investigation into an October 2009 study in Science that claimed to have proven the ability of a device to measure all of the enzyme activity in a cell at a particular time, the journal has asked the study’s authors to retract the paper, Science‘s news blog, ScienceInsider, reported on Friday.

The move comes after Bruce Alberts, Science‘s editor in chief, issued an Editorial Expression of Concern in December in response to concerns raised by other scientists

to alert our readers to thefact that serious questions have been raised about the methodsand data presented in this article. The questions focus in particularon the synthesis of the dye-labeled metabolites that are centralto the microarray technique. In addition, the spectroscopicdata the authors cite in support of their claim were not postedto the Bangor University School of Biological Sciences Web siteat the time of publication, despite the authors’ indicationin the Supporting Online Material that the data would be soposted. In response to inquiries from Science, the authors haveprovided new descriptions of the synthetic methods that differsubstantially from those in their published article. Based onour original concerns and the authors’ response, Science hasrequested evaluation of the original data and records by officialsat the authors’ institutions: These officials have agreed toundertake this task.

That evaluation, reported late last month by Nature, concluded Continue reading Science wants “reactome array” enzyme chip authors to retract paper