”Definitely embarrassing:” Nobel Laureate retracts non-reproducible paper in Nature journal

A Nobel Laureate has retracted a 2016 paper in Nature Chemistry that explored the origins of life on earth, after discovering the main conclusions were not correct.  

Some researchers who study the origins of life on Earth have hypothesized that RNA evolved before DNA or proteins.  If true, RNA would have needed a way to replicate without enzymes. The Nature Chemistry paper found that a certain type of peptide — which may have existed in our early history — made it possible for RNA to copy itself.

Jack W. Szostaka professor of chemistry and chemical biology at Harvard University in Cambridge, Mass., who shared the 2009 Nobel Prize in Physiology or Medicine with Elizabeth Blackburn and Carol Greider for their pioneering research on aging—told us he was “incredibly excited” when he “thought we had at least a partial solution to this problem,” which researchers have been working on for over 50 years.  

But in subsequent experiments, Tivoli Olsen — a member of Szostak’s lab — could not reproduce the 2016 findings. When she reviewed the experiments from the Nature Chemistry paper, she found that the team had misinterpreted the initial data: The peptide in question did not appear to provide an environment that fostered RNA replication.

The errors were “definitely embarrassing,” Szostak told us: Continue reading ”Definitely embarrassing:” Nobel Laureate retracts non-reproducible paper in Nature journal

When publishers mess up, why do authors pay the price?

Springer has retracted two papers, which appeared online earlier this year in different journals, after discovering both were published by mistake.

A spokesperson at Springer explained that the retractions are “due to a human error.”

According to one of the retraction notices, published in Archive for Mathematical Logic, the paper had not yet undergone peer review and the author plans to resubmit his paper to the journal. The other retraction notice, published in Arabian Journal of Geosciences, simply states that an “error in the submission system” is to blame. Unfortunately, in both cases the authors now have a retraction on their record, seemingly through no fault of their own.

Neither notice indicates what publisher glitches led to the premature publications. We asked the spokesperson for clarity, but she did not elaborate. When asked whether Springer has made changes to prevent these errors from happening again, the spokesperson said:

Continue reading When publishers mess up, why do authors pay the price?

Caught Our Notice: What if you find out a paper relied on expired herbal supplement?

Via Wikimedia

Title: Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA- transcription factor-target gene network

What Caught Our Attention: The researchers were studying how curcumin, a component of the spice turmeric, can inhibit lung cancer metastases. But upon learning that the primary material had been expired at the time of testing (and realizing they were unable to repeat their experiments), the researchers pulled their paper. Expiration dates do have safety factors built in, but attention to such details is imperative in research.  Continue reading Caught Our Notice: What if you find out a paper relied on expired herbal supplement?

Caught Our Notice: Don’t count your chicken (genes) before they’re hatched

Via Wikimedia

Title: Molecular Characterization and Biological Activity of Interferon-α in Indian Peafowl (Pavo cristatus)

What Caught Our Attention: Soon after the paper appeared, the journal was alerted to the fact its findings were at odds with others in the field. When the editor approached the authors, everything fell apart: The authors couldn’t repeat the experiments, and “were also unsure of the molecular probes that were used in the study.” While it isn’t unusual to have doubts about data — since since research is a process of experimentation — it is odd not to know how your experiment was conducted. The paper was retracted less than two months after it was published. The manuscript was accepted two months after it was submitted in early May, theoretically giving reviewers enough time to catch these issues (along with the authors’ failure to cite relevant papers).  

Continue reading Caught Our Notice: Don’t count your chicken (genes) before they’re hatched

Scientist to chemistry journal: “Plse retract this ms ASAP”

The presence of allegedly obvious manipulations in a 2017 chemistry paper has prompted a reader outcry.

Over the last couple of days, a user on PubPeer and others on Twitter have accused the paper of containing clear duplications; the paper was already corrected in August, in which one scientist alleges the authors replaced “an obviously fabricated” figure with a “slightly better photo-shopped one.”

In response, the editor of ACS Biomaterials Science & Engineering, David Kaplan, told us:

Continue reading Scientist to chemistry journal: “Plse retract this ms ASAP”

Publisher: “We are disappointed to be parting company with the editorial board”

After the editorial board of a public health journal resigned in protest last week, the publisher is trying to “move on.”

In a statement from Taylor & Francis, the publisher laments that the board of the International Journal of Occupational and Environmental Health “did not wish to take the opportunities offered by ourselves and the editor-in-chief to discuss the journal’s future,” and defended its recent editorial decisions that were questioned by the board.

Since the the spring, the board has vocally protested actions taken by the journal without consulting the editorial board, including its decision to appoint a new editor with industry ties, and the “unilateral withdraw[al]” of a paper by the previous editor that was critical of corporate-sponsored research, with little explanation. In the resignation letter from last week, the board said it did not wish to participate in the “apparent new direction that the journal appears to be moving towards.”

In its statement, the publisher says it has no plans to make “major changes” to the journal:

Continue reading Publisher: “We are disappointed to be parting company with the editorial board”

Caught Our Notice: 1,376 words of overlap in paper by food researcher Brian Wansink

Via Wikimedia

TitleChange Their Choice! Changing Behavior Using the CAN Approach and Activism Research

What Caught Our Attention: Food researcher Brian Wansink has had a rough time lately. After researchers began scrutinizing his work, he has racked up five retractions and multiple corrections. (We’re counting one retracted paper twice, as Wansink first retracted and replaced it with a new version, then retracted the replacement.)

These notices haven’t gone unnoticed, either by us or other media outlets — BuzzFeed reported on his most recent retraction this weekend, a paper a critic discussed with us, as well. Yesterday, BuzzFeed also reported that Cornell is investigating. (It wouldn’t be the first time — in April, Cornell announced that it had found evidence of mistakes, not misconduct, in Wansink’s papers.)  Below, we present his 13th correction, for duplicated text — 1,376 words of duplicated text, to be exact.

Continue reading Caught Our Notice: 1,376 words of overlap in paper by food researcher Brian Wansink

Where’s the data? Authors can’t support figures in 2017 kidney paper

Researchers have retracted a 2017 paper exploring a novel approach to treat kidney injury, because three images were “constructed inappropriately.”

That’s about as much as we know: The retraction notice provides few details about the nature of the issue, only that the authors—most of whom work at Pennsylvania State University College of Medicine in Hershey—could not provide the original data for the recently published figures.

The paper, published in American Journal of Physiology – Renal Physiology, was retracted October 1, just over four months after appearing online in mid-May. Continue reading Where’s the data? Authors can’t support figures in 2017 kidney paper

Caught Our Notice: To know if someone’s been vaccinated, just asking isn’t enough

Via Wikimedia

Title: Hepatitis B Virus Infection in Preconception Period Among Women of Reproductive Age in Rural China – A Nationwide Study

What Caught Our Attention: When researchers set out to study hepatitis B among women in rural China, and they wanted to know if the women had been vaccinated against the virus, they simply asked them. While that can sometimes be useful, apparently it was a mistake in this case, as the reliance on patient memory injected too much doubt into these findings.  Continue reading Caught Our Notice: To know if someone’s been vaccinated, just asking isn’t enough

Caught Our Notice: When authors go MIA, the article may follow

Via Wikimedia

Title: IRF9 inhibits human acute myeloid leukemia through the SIRT1-p53 signaling pathway

What Caught Our Attention: When authors fail to respond to editors’ requests for information, it isn’t hard to imagine that the submitted manuscript will lose its publishing appeal. In this case, the journal and publisher withdrew the article after “repeated attempts” to contact the authors were unsuccessful.

The notice doesn’t say why the journal needed to get in touch with the authors; of course, some authors may cease correspondence for a variety of reasons, but there is usually some backstory. Since the authors disappeared, the withdrawn article has, as well. Continue reading Caught Our Notice: When authors go MIA, the article may follow