Nature cancer paper that raised animal welfare concerns is retracted

When Nature published a paper in 2011 describing a compound extracted from a pepper plant that appeared to kill cancer cells but leave healthy cells unscathed, it got some attention.

Of course, the news caught the media’s eye, but also that of other researchers, who have since jumped on the concept, and continued to study the effects of the compound — piperlongumine — on cancer, as well as other conditions.

But ever since the 2011 letter appeared, researchers have raised concerns about some of the figures — including one that showed mice with massive tumors, suggesting they had experienced an unreasonable amount of distress during the study. Nature has responded by issuing two lengthy correction notices in 2012 and 2015 — as well as an editorial that admitted the animals may have “experienced more pain and suffering than originally allowed for,” but did not warrant retracting, as the results remained “valid and useful.”

Today, the journal is retracting the paper, with the following brief notice:

Continue reading Nature cancer paper that raised animal welfare concerns is retracted

“[T]he data and findings…are unreliable:” Authors explain how a refutation came to be published in the same journal as the original

A rotifer, via Wikimedia

A group of tiny, all-female animals called bdelloid rotifers has long fascinated scientists. Among other questions, of course, is: Why haven’t they gone extinct, if they can’t mix up their genes? In 2016, a group of authors published a paper in Current Biology claiming to show that rotifers could swap DNA the way bacteria do. But a paper published earlier this month in the same journal found “clear evidence that the data and findings of [that study] are unreliable.” It’s unusual for a journal to publish a full paper clearly refuting another — and Current Biology left the original paper as is, without even a link to the new one. The authors of the new paper — Chris Wilson, Reuben Nowell, and Tim Barraclough, all of Imperial College London — explain how all of this came to pass, and why the authors of the original paper deserve praise.

RW: You and others refer to asexual rotifers as an “evolutionary scandal.” Can you explain? Continue reading “[T]he data and findings…are unreliable:” Authors explain how a refutation came to be published in the same journal as the original

Over authors’ objections, PLOS ONE retracts paper claiming Shroud of Turin showed evidence of trauma

A year ago, PLOS ONE published a study claiming that there was strong evidence that a person wrapped in the Shroud of Turin — according to lore, the burial shroud of Jesus Christ — had suffered “strong polytrauma.”

Today, they retracted it.

According to the retraction notice for “Atomic resolution studies detect new biologic evidences on the Turin Shroud,” Continue reading Over authors’ objections, PLOS ONE retracts paper claiming Shroud of Turin showed evidence of trauma

Nearly two years after a university asked for retractions, two journals have done nothing

How long should a retraction take?

That’s a complex question, of course, depending on how long the alleged issues with a paper take to be investigated, whether authors — and their lawyers — fight tooth-and-nail against a retraction, and other factors. But once a university officially requests a retraction, how long should one take?

The answer, for two journals who published work by cancer researcher Anil Jaiswal, is 22 months — and counting. Continue reading Nearly two years after a university asked for retractions, two journals have done nothing

A publisher just retracted ten papers whose peer review was “engineered” — despite knowing about the problem of fake reviews for years

Many publishers have been duped by fake peer reviews, which have brought down more than 600 papers to date. But some continue to get fooled.

Recently, SAGE retracted 10 papers published as part of two special collections in Advances in Mechanical Engineering after discovering the peer review process that had been managed by the guest editors “did not meet the journal’s usual rigorous standards.” After a new set of reviewers looked over the collections, they determined 10 papers included “technical errors,” and the content “did not meet the journal’s required standard of scientific validity.”

Yeah, we’re not exactly sure what happened here, either. SAGE gave us a little extra clarity — but not much.

Continue reading A publisher just retracted ten papers whose peer review was “engineered” — despite knowing about the problem of fake reviews for years

Three years after questions surfaced, PLOS ONE retracts paper about potential antibiotic

In April 2015, two high-profile chemistry bloggers — and their commenters — raised questions about a paper that had been published in PLOS ONE some 18 months earlier. More than three years later, the journal has now retracted the paper, with a notice that echoes the 2015 blog posts.

So what took so long? PLOS tells Retraction Watch: Continue reading Three years after questions surfaced, PLOS ONE retracts paper about potential antibiotic

Researchers pull Nature paper over first author’s objections

Researchers have retracted a 2015 Nature paper about the molecular underpinnings of immune function after discovering they could not replicate key parts of the results.

The first author, Wendy Huang — who started working as an assistant professor at the University of California, San Diego, only months after the paper appeared — did not sign the retraction letter, published last week. The research was conducted while Huang was working as a postdoctoral fellow at New York University, home of last author Dan Littman (also an investigator at the Howard Hughes Medical Institute).

What happened appears to be a case of “he said, she said:” Littman asked to retract the paper after his lab couldn’t reproduce it, and Huang insists the data remain correct, saying the process had been “unfair and done without due process:”

Continue reading Researchers pull Nature paper over first author’s objections

An author says his work should be “widely heralded and promoted.” So he published it 3 times.

Barislav Momčilović thinks that iodine status is — after iron deficiency — the “main public health” issue in the world today. So when he figured out what he believed was the best way to test levels of the mineral, he was determined to get the message out.

A little too determined, perhaps: He published the same information three times. And one journal caught on.  Last week, Thyroid retracted “Hair Iodine for Human Iodine Status Assessment,” a 2014 paper that they say overlapped with two earlier works.

While publishing duplicate work is considered by some to be just a violation of restrictive publisher copyright agreements, the presence of such duplicates in the literature can bias systematic reviews and other attempts to describe the state of the evidence in a given field. In a retraction notice, Thyroid noted that this was a case of Continue reading An author says his work should be “widely heralded and promoted.” So he published it 3 times.

After probe, journal removes flag from four papers, corrects manipulated images

Last year, Journal of Cell Science added notices to four papers after a reader contacted the editors with some concerns about issues with the figures. Now, it’s replacing the previous editorial notices with corrections, which address duplicated images and data.

When the journal issued expressions of concern for four papers co-authored by José Ignacio Rodriguez-Crespo about the allegations (which had also been raised on PubPeer), it notified his institution, the Universidad Complutense de Madrid (UCM). The newly issued correction notices explain that UCM investigated the four papers, and the data support the results and conclusions. In two cases, the authors supplied the original data, and in the others, they replicated the experiments.

Rodriguez-Crespo declined to comment, saying only that the journal

Continue reading After probe, journal removes flag from four papers, corrects manipulated images

A journal decided to correct, rather than retract, a paper that contained “potentially contentious advice.” Do you agree with their call?

In March, a journal published a paper about blood sugar levels in newborns that caused an immediate outcry from outside experts, who were concerned it contained a sentence that could be potentially harmful if misinterpreted by doctors.

Recently, the journal explained — in impressive detail — why it’s not retracting the paper. That, of course, gives readers the ability to form their own opinions. After seeing the pros and cons, let us know if you think the journal made the right call in a poll at the bottom of the story.

When it first appeared, the paper — “Newborn plasma glucose concentration nadirs by gestational-age group,” published by Neonatology — included this sentence in its abstract:

In order to potentially prevent low glucose concentrations at the time of the nadir, exogenous glucose should be provided to all newborns as soon as possible after birth.

According to an editorial note published by the journal’s editors, that caused immediate concern for outside experts:

Continue reading A journal decided to correct, rather than retract, a paper that contained “potentially contentious advice.” Do you agree with their call?