NEJM corrects 3 papers after prominent cancer scientist left off credit for breakthrough

Screen Shot 2016-03-15 at 12.04.43 PMThe New England Journal of Medicine has corrected three highly cited papers to credit researchers who played a role in the work.

The papers describe a treatment in which engineered T cells fight leukemia, originally hailed as a “major advance” in the New York Times. Since the first paper appeared in 2011, co-author Carl June at the University of Pennsylvania has received more than $7 million in grants from the National Institutes of Health, according to MIT Technology Review. But according to a newly published correction, the three NEJM papers failed to note in the acknowledgement section that an important component of the experiments was supplied by researchers at St. Jude Children’s Research Hospital.

The correction, made 11 months after a request from co-author and Penn researcher David Porter, explains the contribution of the St Jude’s researchers:

Continue reading NEJM corrects 3 papers after prominent cancer scientist left off credit for breakthrough

What did retractions look like in the 17th century?

Alex Csiszar
Alex Csiszar

We always like to get a historical perspective on how scientists have tried to correct the record, such as this attempt in 1756 to retract a published opinion about some of the work of Benjamin Franklin. Although that 18th century note used the word “retract,” it wasn’t a retraction like what we see today, in which an entire piece of writing is pulled from the record. These modern-day retractions are a relatively recent phenomenon, which only took off within the last few decades, according to science historian Alex Csiszar at Harvard University. He spoke to us about the history of retractions – and why an organization like Retraction Watch couldn’t have existed 100 years ago.

Retraction Watch: First of all, let’s start with something you found that appears to break our previous record for the earliest retraction – a “retractation” by William Molyneux of some assertions about the properties of a stone, published in 1684. Could this be the earliest English-language retraction? Continue reading What did retractions look like in the 17th century?

Whistleblower removed from Macchiarini’s Lancet author list

Paolo Macchiarini
Paolo Macchiarini

Last week, The Lancet honored a co-author’s request to remove his name from Paolo Macchiarini’s seminal 2011 paper, which described the first transplant of an artificial trachea seeded with autologous stem cells but has since come under fire.

On March 3, the journal posted this notice:

The Lancet has been contacted by Dr KH Grinnemo who was an author on the paper. Dr Grinnemo no longer wishes to be an author and asks for his name to be removed. This correction has been made to the online version as of March 3, 2016.

The paper has been cited 187 times, designating it “highly cited” by Thomson Reuters Web of Science.

As The Scientist reports, Karl-Henrik Grinnemo is one of the four surgeons at Karolinska Hospital who filed a complaint against Macchiarini in 2014 — alleging, for instance, Continue reading Whistleblower removed from Macchiarini’s Lancet author list

Macchiarini may be dismissed from Karolinska; dean of research resigns

Paolo Macchiarini
Paolo Macchiarini

There’s more news to report on the story of surgeon Paolo Macchiarini, who’s been dogged by allegations of misconduct.

After the Karolinska Institutet (KI) announced it would not extend his contract and that he needed to “phase out” his research by November, it has now announced it may dismiss him.

In addition, Hans-Gustaf Ljunggren, KI’s Dean of Research, has resigned.

Here’s the statement we received from a KI spokesperson:

Continue reading Macchiarini may be dismissed from Karolinska; dean of research resigns

Karolinska vice-chancellor resigns following criticism of Macchiarini investigation

Anders Hamsten
Anders Hamsten

Anders Hamsten announced he would be resigning as vice-chancellor from Karolinska Institutet (KI) in the early hours of Saturday, February 13.

In a press release we received at 12:16 a.m. local time in Stockholm, Hamsten issued the following statement:

Following the criticism on the so called Macchiarini affair at KI I conclude it will be hard for me to serve as Vice-Chancellor with the strength and credibility this university needs. I will therefore leave office.

Good thing we published a primer on the whole story a few hours ago. To recap: Continue reading Karolinska vice-chancellor resigns following criticism of Macchiarini investigation

Karolinska orders new investigation of trachea surgeon Macchiarini

Paolo Macchiarini
Paolo Macchiarini

The Karolinska Institutet University Board announced today it was issuing a new external investigation of trachea surgeon Paolo Macchiarini, looking into questions about his recruitment and the handling of previous allegations of misconduct.

According to a press release:

The University Board deems such an inquiry to be an important part of restoring the confidence of the public, the scientific community, staff and students in the university.

The board hopes to appoint the investigative team, which will not consider “matters of a medical-scientific nature,” next week. The goal is to conclude the investigation by the summer.

There were many signs this was coming:  Continue reading Karolinska orders new investigation of trachea surgeon Macchiarini

Karolinska won’t extend star surgeon Macchiarini’s contract

dr-paolo-macchiarini
Paolo Macchiarini

Karolinska Institutet announced today it would not extend the contract of star surgeon Paolo Macchiarini. He has been instructed to “phase out” his research from now until November 30.

According to a press release issued today: Continue reading Karolinska won’t extend star surgeon Macchiarini’s contract

Stem cell researcher who sued Harvard, Brigham & Women’s is leaving his post

anversa
Piero Anversa
A stem cell researcher who sued his employers, Harvard and Brigham & Women’s Hospital, is headed to Switzerland.

Piero Anversa‘s departure follows the dismissal of his suit last summer. Anversa filed the suit with colleague Annarosa Leri, claiming that an investigation into their work damaged their reputations:

they lost a multimillion-dollar offer to purchase their company, Autologous/Progenital; and both Plaintiffs have had possible employment offers at several institutions postponed.

Anversa’s lawyer, Tracey Miner, confirmed that he was moving:

Continue reading Stem cell researcher who sued Harvard, Brigham & Women’s is leaving his post

Intellectual property issues sink cancer paper in JACS

176 spine minimum. full size. Editor: Lingling JEM: Leslie RTP: Michael ReidThe authors of a paper on a mechanism for potential cancer therapies are retracting it after realizing they published some proprietary findings “without permission and agreement from St. Jude Children’s Research Hospital.”

According to the retraction note in Journal of the American Chemical Society, the authors included an X-ray crystal structure and data that were gathered at St. Jude’s and considered the hospital’s intellectual property. On the paper, the last author, Zhengding Su, listed an affiliation at St. Jude and Hubei University of Technology in China, along with Amersino Biodevelop Inc., based in Waterloo, Canada.

Here’s the note for “Efficient Reactivation of p53 in Cancer Cells by a Dual MdmX/Mdm2 Inhibitor:”  Continue reading Intellectual property issues sink cancer paper in JACS

St. Jude investigation finds faked data in brain tumor paper

S00396060An investigation at St. Jude Children’s Hospital into “irregularities” in a figure featured in a neuroblastoma paper has concluded that the image was fabricated. The paper, published in Surgery in 2012, was retracted on Friday.

Here’s the full retraction notice for “Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition:”

Continue reading St. Jude investigation finds faked data in brain tumor paper