Category: united states

U Colorado “golden boy” grad student faked data in drug lab, says investigation

u coloradoA graduate student at the University of Colorado Denver faked data in his work at a drug research lab that has notched two retractions and an expression of concern over “data integrity,” according to an extensive university investigation.

It seems like many more retractions are on the horizon for grad student Rajendra Kadam, who worked in the lab of Uday Kompella, a pharmaceutical researcher at the university.  

Here’s an excerpt from the report, which you can read in full (but redacted) here: Continue reading U Colorado “golden boy” grad student faked data in drug lab, says investigation

Drug company lawyer letter results in “utterly tedious” retraction

Image via Intropen
Image via Intropen

What’s in a name?

Well, if it’s the same name as a treatment with nearly $1 billion in sales per year in the U.S., a retraction.

A “mind numbingly boring one,” that is.

Here’s the Twin Research and Human Genetics notice for “EpiPen: An R Package to Investigate Two-Locus Epistatic Models”: Continue reading Drug company lawyer letter results in “utterly tedious” retraction

PLOS Genetics investigating paper by Ariel Fernandez

Ariel Fernandez, via Wikipedia
Ariel Fernandez, via Wikipedia

Ariel Fernandez‘s list of papers with editorial asterisks next to them grew again this week.

Fernandez has had one paper retracted, two papers subject to Expressions of Concern, including one from Nature, and another put on hold over data concerns. He threatened to sue us for covering one of the Expressions of Concern.

Here’s the “Notice from PLOS Genetics” for “Protein Under-Wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability:”

Please be advised that PLOS is working with the authors on an investigation regarding one or more issues that have been raised with respect to the content or authorship of this paper.

We asked Fernandez for more details. He did not provide any, saying only that the criticisms of the work “have no scientific value” because they were made anonymously: Continue reading PLOS Genetics investigating paper by Ariel Fernandez

Water under the bridge? Hydrology journals won’t retract plagiarized papers despite university request

hydrogeology journalIn April 2014, we wrote about the case of a former hydrologist at the University of Kansas (KU), Marios Sophocleous, who had plagiarized in at least seven studies, two of which were retracted by the journal Ground Water.

At the time, we mentioned two other articles, in the Hydrogeology Journal, that appeared destined for retraction — not least because KU requested that the journal yank them. But in a rather surprising move, the journal is declining to do so, and another publication, the Journal of Hydrology, is taking the same approach.

Here’s the notice from Hydrogeology Journal editor Clifford Voss: Continue reading Water under the bridge? Hydrology journals won’t retract plagiarized papers despite university request

Paper on cranberries’ health benefits retracted after researcher forges authors’ names

Image via Bruce Foster.
Image via Bruce Foster.

A paper in Food Chemistry suggesting cranberry extract has healing properties was retracted after some of the authors complained they had no idea the paper was being published.

Here’s the notice for “Phenolic composition, antioxidant properties, and endothelial cell function of red and white cranberry fruits:” Continue reading Paper on cranberries’ health benefits retracted after researcher forges authors’ names

Thalidomide paper retracted for lab error

fertstertResearchers at the University of Pittsburgh have retracted a paper on using thalidomide, which led to an estimated 10,000 birth defects by the time the drug was pulled from the market in 1961, to prevent chemo-induced sterility.

Alkylating agents, which prevent DNA replication in cells, are a commonly-used cancer treatment. Unfortunately they also damage the ovaries and testes, sometimes causing infertility. The University of Pittsburgh scientists published a paper in Elsevier journal Fertility and Sterility in 2011 that suggested thalidomide, which causes severe birth defects when used during pregnancy, might help protect ovaries during chemo.

However, according to the notice, the authors tried and failed to replicate their results. They had two separate scientists who were not authors take a look at the results; everyone agreed that the original study incorrectly reported the number of primordial follicles, the precursor to mature eggs.

Here’s the notice for “Thalidomide treatment attenuates chemotherapy-induced gonadal toxicity”: Continue reading Thalidomide paper retracted for lab error

Nature Cell Biology insulin paper retracted over antibody problems

nature cell biologyA Nature Cell Biology article on insulin regulation has been retracted after scientists noted that the antibodies used in their research were not as specific as they had previously believed.

The notice is clear on the problems with the science, which together “call into question the main conclusions of the paper.” Three of the paper’s five authors were employed at Novartis at the time of publication.

Here’s the notice for “Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion”: Continue reading Nature Cell Biology insulin paper retracted over antibody problems

Paper recommending calorie limits on Happy Meals retracted

Image via Stefan

A paper estimating the effects of limiting fast food meals with toys to under 550 calories has been retracted after concerns arose regarding the scientists’ use of an outdated model for estimating weight changes in kids.

The paper estimated that kids who eat fast food twice a week would avoid gaining two pounds a year if calorie limits are imposed on meals with toys. However, everyone we spoke to, and the notice, indicated that their estimate was inaccurate.

Here’s the notice for “Modeling Potential Effects of Reduced Calories in Kids’ Meals with Toy Giveaways”:

Continue reading Paper recommending calorie limits on Happy Meals retracted

PubPeer files motion to dismiss Sarkar defamation case

sarkarAttorneys representing PubPeer in its defense against a subpoena by cancer researcher Fazlul Sarkar, of Wayne State University in Michigan, have submitted a motion to the Wayne County Circuit Court to quash the matter.

Sarkar’s work has appeared on the anonymized post-publication peer review site, and he isn’t happy about it. In October, he sued the site’s commenters, demanding that PubPeer release the names of his accusers. Sarkar, who has not been found to have committed research misconduct, claims he lost a lucrative job offer at the University of Mississippi as a result of the posts.

The motion — available here — argues that even if the claims of image irregularities levied against Sarkar by anonymous PubPeer posters are untrue, they don’t meet conventional standards of defamation: Continue reading PubPeer files motion to dismiss Sarkar defamation case

Faking data earns stem cell researcher a ban on federal funding

Screen shot 2014-12-09 at 12.01.19 PMThe Office of Research Integrity (ORI) has sanctioned Kaushik Deb, a former post-doc at the University of Missouri-Columbia, who “engaged in misconduct in science by intentionally, knowingly, and recklessly” fabricating data in papers in both Science and Nature (which ultimately rejected his manuscript).

Deb was big news in 2007, when Science retracted his paper. Articles about the case appeared in many outlets, including The Scientist and USA Today. At the time, Missouri’s research integrity officer, Rob Hall, told the Columbia Tribune that: Continue reading Faking data earns stem cell researcher a ban on federal funding