PNAS retracts two papers on osmolytes after researchers discover crucial measurement errors

A good carpenter never blames his tools. But for scientists, sometimes machines do go bad–with disastrous results. Consider the following:

The Proceedings of the National Academy of Sciences has retracted two papers by researchers in the United Kingdom and the United States after the scientists learned that their results were based largely on a problem with their highly sensitive instruments.

Continue reading PNAS retracts two papers on osmolytes after researchers discover crucial measurement errors

Why editors should stop ignoring anonymous whistleblowers: Our latest LabTimes column

A retraction notice appeared a few months ago in the Biophysical Journal:

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).

This article has been retracted at the request of Edward Egelman, Editor-in-Chief.

The editors have noted that there is a substantial overlap of figures and text between this Biophysical Journal article and D. Rutkauskas, V. Novoderezkhin, R.J. Cogdell and R. van Grondelle. Fluorescence spectral fluctuations of single LH2 complexes from Rhodopseudomonas acidophila strain 10050. Biochemistry, 43 (2004) 4431–4438, doi:10.1021/bi0497648. The submission of this paper was inconsistent with the Biophysical Journal policy which states: “Manuscripts submitted to Biophysical Journal (BJ) must be original; papers that have already been published or are concurrently submitted elsewhere for publication are not acceptable for submission. This includes manuscripts previously submitted to BJ, as well as material that has been submitted to other journals while BJ is considering the manuscript. If some part of the work has appeared or will appear elsewhere, the authors must give the specific details of such appearances in the cover letter accompanying the BJ submission. If previously published illustrative material, such as figures or tables, must be included, the authors are responsible for obtaining the appropriate permissions from the publisher(s) before the material may be published in BJ”. We are therefore retracting the publication of the Biophysical Journal article.

Ordinarily, such duplications go to the bottom of our list of retractions to cover, despite how common they are. There’s usually less of a story behind them than there is behind a completely opaque notice, or behind one that sports a whiff of fraud. But they’re still important, as Bruce Chabner, the editor of The Oncologist, pointed out in a recent issue of his journal in which a duplication retraction appeared: Continue reading Why editors should stop ignoring anonymous whistleblowers: Our latest LabTimes column

Lab squabble leads to retracted correction over authorship in British Journal of Haematology

Here’s a he said-he said that left one author with a publication, then nothing, and us scratching our heads.

In March 2010, the British Journal of Haematology issued a rather straightforward correction regarding a 2007 article by a group of researchers from Kansas Kansas City, Missouri.

The glitch? The manuscript evidently left out an author:

In Iyamu et al (2007), the list of authors was incorrectly published and should have read:

Efemwonkiekie W. Iyamu, Syed Jamal, Chiazotam Ekekezie and Gerald M. Woods

Or maybe not. The journal is now retracting the correction: Continue reading Lab squabble leads to retracted correction over authorship in British Journal of Haematology

New retraction sheds light on Medical College of Georgia vascular biology case

In late January, we wrote a post about a retraction in the journal Molecular Endocrinology involving work from the lab of Stephen M. Black, of the Vascular Biology Center at at the Medical College of Georgia.

At the time, we didn’t know much. The notice was pretty thin sauce, although it hinted at “significant concerns with the data,” and we were led to believe that the first author of the article, Neetu Sud, a post-doc in Black’s lab, might have been implicated in those concerns. Because Black’s lab was working with substantial amounts of NIH funding, the prospect of an investigation by the Office of Research Integrity seemed likely.

Now we have a little more to go on. The American Journal of Physiology: Lung Cellular and Molecular Physiology has retracted another article by Sud and Black. The paper, titled “Protein kinase Cδ regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation,” appeared in 2008 and included a third author, Stephen Wedgwood, of Northwestern University. It has been cited 10 times, according to Thomson Scientific’s Web of Knowledge.

Here’s the notice: Continue reading New retraction sheds light on Medical College of Georgia vascular biology case

Two murky retractions in Chemosphere for authorship issues

The journal Chemosphere has retracted two papers over authorship concerns. The problem is, we don’t really know what those concerns are.

Here’s one notice: Continue reading Two murky retractions in Chemosphere for authorship issues

Materials paper retracted after post-doc’s plagiarism

The Journal of Materials Science: Materials in Medicine has retracted a 2011 paper after it was determined that the first author, then a post-doc at the University of Michigan, had plagiarized from another publication.

The first author of the retracted article, “Functionalization of titanium based metallic biomaterials for implant applications,” was the post-doc, Rahul Bhola, who received his PhD from the Colorado School of Mines and went to Michigan to work in the lab of Catherine Krull.

Fruit of that relationship was the paper — and here’s how that worked out: Continue reading Materials paper retracted after post-doc’s plagiarism

Retraction comes as death of PI leads to lost records

The Journal of Experimental Medicine has retracted a 2011 article after the principal investigator’s home institution suggested that the PI might have manipulated his data. Complicating matters, the PI in this case died two weeks after the paper appeared and his notes have gone missing — making an affirmative declaration of fraud or honest error difficult.

Here’s the notice: Continue reading Retraction comes as death of PI leads to lost records

Elsevier ob-gyn journal retracted paper after legal threat

When we broke the story last week about a juicy retraction notice in the American Journal of Obstetrics & Gynecology (AJOG) — known by its readers as “the Gray Journal” — we wrote that there was more to it than we suspected. That’s an understatement.

As we reported, the AJOG retracted an article that it had published earlier this year because 1) the author, Laurence Cole, had failed to disclose a potential financial conflict of interest with a pregnancy test maker named Church & Dwight; and 2) the article lacked a “credible scientific reason given for conducting the study,” along with other flaws detailed in the notice. (As we wrote the other day, we wonder why those issues did not arise during the initial review of the manuscript — but more on that shortly.)

We’ve since learned that the journal’s move came after it received a sharply worded letter from a high-powered San Francisco lawyer demanding immediate retraction of the article on the grounds that it represented a “substantial” threat to the financial health of his client. That client? A maker of home pregnancy tests who is now in the process of suing the very firm that provided Cole with research funding he failed to disclose.

First, here’s what Cole,  the hormone expert at the University of New Mexico whose paper the journal retracted, said about why he didn’t disclose that funding: Continue reading Elsevier ob-gyn journal retracted paper after legal threat

Retraction (in all but name) of flu paper raises eyebrows

When is a retraction not a retraction? Why, when it’s a correction, of course — like the one the journal Emerging Infectious Diseases issued this month:

In the article Reassortment of Ancient Neuraminidase and Recent Hemagglutinin in Pandemic (H1N1) 2009 Virus (P. Bhoumik, A.L. Hughes), errors were made in selection of the hemagglutinin (HA) and neuraminidase (NA) sequences for the initial and subsequent data sets. As a result, the authors incorrectly concluded that the NA gene of the pandemic (H1N1) 2009 virus is of a more ancient lineage than the HA. Other researchers (and the authors) have not been able to reproduce the findings when using HA and NA matched pairs from viruses chosen on the basis of geography and time and correctly have pointed out errors in the data set that make the original conclusions invalid.

In other words, 1) the article was based largely on an error and 2) the central point could not be reproduced, two flaws that, at least in our book, usually constitute grounds for retraction.

The paper was written by Priyasma Bhoumik and Austin Hughes. Bhoumik, now a post-doc at Harvard, at the time was a PhD student at the University of South Carolina, where Hughes is a senior faculty member. Funding for the work came to Hughes from the National Institutes of Health, according to the original article.

We spoke with Hughes, who said that in this case, correction versus retraction is a distinction without a difference: Continue reading Retraction (in all but name) of flu paper raises eyebrows

Ob-gyn journal pulls pregnancy test paper for undeclared conflict of interest, other problems

The American Journal of Obstetrics and Gynecology (AJOG) as a remarkable retraction notice in its November issue — the likes of which we haven’t seen before.

A little background: Earlier this year, Laurence Cole, an academic obstetrics specialist at the University of New Mexico in Albuquerque, published a paper in the AJOG looking at the wide variability in the hormone human chorionic gonadotropin, or hCG, during pregnancy (we’d link to the article, but the journal has pulled it, so here’s the abstract on Medline).

Cole runs — or did run until recently, more on that in a moment — the USA hCG Reference Service at the university, which purports to be the only lab in the world that can measure all forms of hCG. He has published extensively in this area of research, with at least 125 papers to his name on the subject, according to a Medline search. One of his websites puts the figure at 246.

So Cole was definitely a known quantity to the journal editors when he submitted his manuscript and when it was published online in February of this year. That’ll be more important in a bit. But first, the retraction notice: Continue reading Ob-gyn journal pulls pregnancy test paper for undeclared conflict of interest, other problems