ORI finds Parkinson’s-pesticides researcher guilty of faking data; two papers to be retracted

The U.S. Office of Research Integrity (ORI) has found that a neuroscientist who studied the effects of pesticides on a mouse model of Parkinson’s disease made up data.

As The Scientist reported on Friday, the ORI found that Mona Thiruchelvam faked cell counts in two grant applications and a number of papers that claimed to show how the pesticides paraquat, maneb, and atrazine might affect parts of the brain involved in Parkinson’s. The Scientist notes: Continue reading ORI finds Parkinson’s-pesticides researcher guilty of faking data; two papers to be retracted

Authors retract PLoS Medicine foreign health aid paper that had criticized earlier Lancet study

On May 8, PLoS Medicine published a paper by Rajaie Batniji and Eran Bendavid of Stanford University, about “whether development assistance for health provided to developing country governments increases health expenditures.”

That paper caught the eye of the Center for Global Development’s David Roodman. He began a May 14 blog post about the study, “The Health Aid Fungibility Debate: Don’t Believe Either Side,” as follows: Continue reading Authors retract PLoS Medicine foreign health aid paper that had criticized earlier Lancet study

Is post-hoc statistical analysis the new fraud detection tool? A new review looks at fraudster Reuben’s work

In the beginning, there was Scott Reuben.

Well, not quite. Reuben, a Massachusetts anesthesiologist who fabricated data and briefly topped our list of most-retracted authors, didn’t invent research fraud, although he did spend six months in federal prison for his crimes. But his case was in no small measure responsible for the birth of this blog, and, well, the rest of human history that followed.

Although Reuben’s retractions are behind him now — his count ends at 22 — and other scientists, including two anesthesiologists, Joachim Boldt and Yoshitaka Fujii, have or likely soon will dramatically eclipsed his mark, a new paper has revisited his publications with an eye toward seeing if they could identify statistical evidence of data manipulation. It’s the same  kind of effort that Ed Yong highlighted as noteworthy about the Dirk Smeesters case, which we covered yesterday and which involved an anonymous statistically inclined whistleblower.

Before we get to whether there was evidence of such manipulation Continue reading Is post-hoc statistical analysis the new fraud detection tool? A new review looks at fraudster Reuben’s work

JPET peeves: Paper withdrawn after drug company won’t disclose chemical structure

A group of researchers at the drug company ChemoCentryx is withdrawing a 2012 paper in the Journal of Pharmacology and Experimental Therapeutics over failure to appropriately identify the molecule they describe in the article.

The withdrawal notice tells the story: Continue reading JPET peeves: Paper withdrawn after drug company won’t disclose chemical structure

Two new corrections for Utah group that retracted two Cell Metabolism papers for missing notebooks

We have an update on the case of a University of Utah lab that retracted two Cell Metabolism papers last month after a fired lab technician disposed of two lab notebooks without permission. The team has now corrected two other papers, one in Blood and the other in the Journal of Clinical Investigation.

Here’s the notice from Blood: Continue reading Two new corrections for Utah group that retracted two Cell Metabolism papers for missing notebooks

Lead author of major breast cancer study announced at ASCO co-authored two corrected papers with Anil Potti

One of the biggest stories so far out of the American Society of Clinical Oncology (ASCO) meeting that just ended in Chicago was that of T-DM1, which, according to Ivan’s Reuters colleagues, “extended the length of time breast cancer patients lived without their disease getting worse.” (The news was even the subject of an embargo break.)

The widely-hailed study of Roche’s drug was led by Duke’s Kimberly Blackwell, who told The New York Times: Continue reading Lead author of major breast cancer study announced at ASCO co-authored two corrected papers with Anil Potti

Retraction count for resveratrol researcher Dipak Das rises to 12

Das, via UConn

Dipak Das, the UConn researcher whom the university earlier ths year found to have fabricated or falsified data more than 100 times, has four more retractions to his name.

The notices appear in the June 1, 2012 issue of the American Journal of Physiology: Heart and Circulatory Physiology, and suggest that Das was not all that cooperative: Continue reading Retraction count for resveratrol researcher Dipak Das rises to 12

Millennium Villages Project forced to correct Lancet paper on foreign aid as leader leaves team

A senior member of a high-profile foreign aid research team has left the project on the heels of a Lancet correction of a heavily criticized paper the team published earlier this month.

Paul Pronyk, who until last week was director of monitoring and evaluation at Columbia University’s Center for Global Health and Economic Development, which runs the Millennium Villages Project, wrote a letter to the Lancet acknowledging errors in the paper, “The effect of an integrated multisector model for achieving the Millennium Development Goals and improving child survival in rural sub-Saharan Africa: a non-randomised controlled assessment,” originally published May 8. That admission came after Jesse Bump, Michael Clemens, Gabriel Demombynes, and Lawrence Haddad wrote a letter criticizing the work, which was published this week accompanied by corrections to the paper: Continue reading Millennium Villages Project forced to correct Lancet paper on foreign aid as leader leaves team

An Immunity retraction for Luk van Parijs, three years after the ORI found evidence of fabrication in the paper

Earlier this month, we reported on a correction by Luk van Parijs, the biologist the Massachusetts Institute of Technology (MIT) fired in 2005 after he admitted to making up data.

Immunity has now run a retraction involving van Parijs, dated May 25, 2012, for 2003’s “Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1”: Continue reading An Immunity retraction for Luk van Parijs, three years after the ORI found evidence of fabrication in the paper

Not for the faint of heart: Cardiologists retract syncope paper after realizing data columns weren’t aligned right

Improperly aligned columns have cost researchers at the Mayo Clinic a paper in the Journal of the American College of Cardiology.

The paper originally concluded that fainting spells (syncope) give patients with high blood pressure in their lung arteries poor prognoses, an observation that turned out to be incorrect.

The problem? The group merged two electronic databases, but did not align columns properly, a problem found only after first author Rachel Le revisited the dataset looking to cull more data.

The retraction notice published on May 22 (the one on ScienceDirect is free to air, while the one on the JACC site is behind a paywall): Continue reading Not for the faint of heart: Cardiologists retract syncope paper after realizing data columns weren’t aligned right