Category: basic life sciences retractions

Should Linus Pauling’s erroneous 1953 model of DNA be retracted?

Linus Pauling, via Wikimedia

We love history at Retraction Watch, but with few exceptions, such as covering what seems to have been the first-ever English language retraction in 1756, the daily march of retractions doesn’t leave us much time to take steps back. So we’re very glad to be able to present a guest post by our friend Jeff Perkel about a classic paper that scientists have known to be wrong for most of its nearly 60-year-life — and yet remains in the literature.

The date is December 31, 1952. Linus Pauling, the CalTech wunder-chemist who had recently solved the secondary structure of proteins by describing the alpha-helix and the beta-sheet, has just submitted a “Proposed Structure for the Nucleic Acids” to the Proceedings of the National Academy of Sciences. The PNAS description appears in February 1953 and runs for 14 pages, with seven figures and two tables (compare that with Watson and Crick’s one-pager two months later in Nature).

Pauling also submitted a short note to Nature to alert that journal’s readers to the basics of the PNAS paper. The Nature note appeared in the journal’s February 21 issue: Continue reading Should Linus Pauling’s erroneous 1953 model of DNA be retracted?

Author whose duplications forced Cell correction retracts paper on Down syndrome

Sebastian Schuchmann, a neuroscience researcher whose duplication errors led to a Cell correction last year, has retracted a 12-year-old paper in the Journal of Neurochemistry whose figures were copied from two of his earlier papers.

Here’s the notice: Continue reading Author whose duplications forced Cell correction retracts paper on Down syndrome

Biologists delete paper from literature after realizing they’d deleted too many genes

Researchers deleted more genes than they bargained for in a Drosophila strain, a mistake that resulted in a retraction of a paper from 2007.

Ron Wides, a biologist specializing in pattern development at Bar-Ilan University, Israel, and colleagues have retracted a paper published in Mechanisms of Development after his lab found that their technique to delete the Ten-a gene ended up deleting other nearby genes, too.

It was deletions of other genes, and not Ten-a, that killed the fruit flies, Wides concluded. His group had also concluded, erroneously, that Ten-a is what’s known as a “pair-rule” gene. Fruit fly embryos develop in stacked segments, like tubes of Pringles; pair-rule genes guide the development of alternating segments. Those other loci, and not Ten-a, caused lethality and caused the flies to develop improperly early,  Wides concluded.

The retraction reads in full: Continue reading Biologists delete paper from literature after realizing they’d deleted too many genes

Korean stem cell investigation expands to another researcher, and more papers

Last month, we brought you the story of Soo-Kyung Kang, a Seoul National University stem cell researcher who has now retracted four papers amidst questions about image manipulation in a total of 14 studies. That story has drawn a great deal of attention in Korea, with comparisons to the Woo-Suk Hwang scandal, and has even led to a profile of Retraction Watch in the Seoul Daily, one of Korea’s largest newspapers.

We’ve now learned that the investigation has grown to 25 papers after an anonymous whistleblower warned about possible data fabrications in another paper by Kang, an associate professor of veterinary biotechnology, and Kyung-Sun Kang, director of the Adult Stem Cell Research Center in the same department (but no relation). And Soo-Kyung Kang was investigated in 2010, according to the Korea Herald.

The researchers’ labs are also under lockdown Continue reading Korean stem cell investigation expands to another researcher, and more papers

FASEB J retracts 15-year-old study after author comes forward, but universities decline to investigate

The FASEB Journal — FASEB stands for the Federation of American Societies for Experimental Biology — is retracting a 15-year-old paper without the consent of all of the authors, despite what seem like valiant attempts to figure out exactly what went wrong.

Here’s the notice for the University of Bern-University of Urbino paper:
Continue reading FASEB J retracts 15-year-old study after author comes forward, but universities decline to investigate

Retraction count for resveratrol researcher Dipak Das rises to 12

Das, via UConn

Dipak Das, the UConn researcher whom the university earlier ths year found to have fabricated or falsified data more than 100 times, has four more retractions to his name.

The notices appear in the June 1, 2012 issue of the American Journal of Physiology: Heart and Circulatory Physiology, and suggest that Das was not all that cooperative: Continue reading Retraction count for resveratrol researcher Dipak Das rises to 12

An Immunity retraction for Luk van Parijs, three years after the ORI found evidence of fabrication in the paper

Earlier this month, we reported on a correction by Luk van Parijs, the biologist the Massachusetts Institute of Technology (MIT) fired in 2005 after he admitted to making up data.

Immunity has now run a retraction involving van Parijs, dated May 25, 2012, for 2003’s “Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1”: Continue reading An Immunity retraction for Luk van Parijs, three years after the ORI found evidence of fabrication in the paper

Authors retract two Cell Metabolism papers after “data were inappropriately removed from the laboratory”

A group of researchers at the University of Utah has retracted two papers from Cell Metabolism after they realized that a dismissed employee had tossed out data that were the basis of some error-laden figures.

Here’s the notice for both papers: Continue reading Authors retract two Cell Metabolism papers after “data were inappropriately removed from the laboratory”

Leading cancer vaccines researcher retracts paper for figure “discrepancies” flagged by watchdog blog

Gerold Schuler, a German immunology researcher who shared the 2006 Deutscher Krebspreis — aka the German Cancer Prize — for his work that contributed to cancer vaccines has retracted a paper in International Immunology following concerns raised by a German science watchdog blog.

Here’s the notice: Continue reading Leading cancer vaccines researcher retracts paper for figure “discrepancies” flagged by watchdog blog

Whistleblower forces retractions of four stem cell papers amid questions about more than a dozen studies

In a case that is a good reminder of why journal editors shouldn’t ignore anonymous tips, a Seoul National University stem cell researcher has been forced to retract four papers, and withdraw another under peer review, in Antioxidants & Redox Signaling following a whistleblower’s exhaustive analysis.

Two retractions by Soo Kyung Kang, a professor of veterinary biotechnology at Seoul National University, appeared on May 9 after an anonymous whistleblower sent a 70-slide PowerPoint presentation to the editors of ten journals that contained evidence of suspicious floating error bars, errors larger than actual measurements, pasted-together lanes in PCR gels and RNA and CHIP blots and several cases where the same control blot data is shown across different experiments and in different papers. In all, the whistleblower raises questions about 14 papers in the ten journals.

Here is the May 9 notice for “Nuclear Ago2/HSP60 contributes to broad spectrum of hATSCs function via Oct4 regulation”: Continue reading Whistleblower forces retractions of four stem cell papers amid questions about more than a dozen studies