A Cell paper reporting on genetic mutations responsible for a form of muscular dystrophy was retracted earlier this month. According to the retraction:
Our paper reported the identification of mutations in the gene VMA21 in patients with X-linked myopathy with excessive autophagy (XMEA) and characterized the molecular mechanisms underlying the disease phenotype. Many of the figure panels in the paper summarize data from multiple experiments. We have now detected a number of errors in these panels. Although we stand by the validity of our conclusions, we believe that the most responsible course of action is to retract our paper. We are preparing an expanded version of our work for future submission. We deeply regret this circumstance and apologize to the community.
One of the original authors, Dr. Aubourg, could not be reached regarding this Retraction.
The study has been cited 11 times, according to Thomson Scientific’s Web of Knowledge. Here’s a press release the researchers’ hospital, Sick Kid’s of Toronto, sent out when it was originally published.
Two of Woo’s post-doctoral fellows at Mount Sinai School of Medicine were dismissed for “research misconduct,” said Ian Michaels, a spokesman for the institution. According to Michaels:
When Dr. Savio L C Woo came to suspect that two post-doctoral fellows in his laboratory may have engaged in research misconduct he notified the Mount Sinai Research Integrity Office. Mount Sinai immediately initiated institutional reviews that resulted in both post-doctoral fellows being dismissed for research misconduct. At no time were there allegations that Dr. Woo had engaged in research misconduct. As part of its review, the investigation committee looked into this possibility and confirmed that no research misconduct could be attributed to Dr. Woo, who voluntarily retracted the papers regarding the research in question. Mount Sinai reported the results of its investigations to the appropriate government agencies and continues to cooperate with them as part of its commitment to adhere to the highest standards for research integrity.
We have plenty of other questions for Mount Sinai about the details of the investigation—including when the post-docs were let go, which Michaels declined to answer—and will update when we learn more.
Research from the lab of Savio Woo, a leading U.S. gene therapy scientist, has come into question with the retraction by major journals of at least four of his articles.
The papers, which appeared in the Proceedings of the National Academy of Sciences, the Journal of the National Cancer Institute and Human Gene Therapy, involve findings published between 2005 and 2009, address various aspect of gene therapy. Two of the articles boasted of potential breakthroughs, and even a possible cure, for diseases with extremely high rates of mortality.
The study in JNCI, for example, reported the finding of a genetically modified bacterium that showed promise for the treatment of pancreatic cancer, a particularly lethal malignancy, and other tumor types. Another, published in 2005 in PNAS, claimed to have discovered a possible cure for phenylketonuria, or PKU, in mice—a finding that was cited more than 30 times and trumpeted in the media.