Category: cancer biology

Animal welfare breach prompts Nature correction

cover_nature (1)A 2011 letter to Nature from Harvard researchers received its second correction today, this time after discovering the researchers conducted experiments in which mice may have “experienced more pain and suffering than originally allowed for.”

That quote comes from an accompanying editorial in the journal, a rare move for a correction to a 2011 letter. But it’s an unusual correction, for a letter that found that a component of a pepper plant appeared to selectively kill cancer cells, leaving healthy cells relatively unscathed.

Here’s the first paragraph from the detailed correction notice, published today: Continue reading Animal welfare breach prompts Nature correction

Fourth retraction for Einstein oncologist due to image manipulations

home_cover (1)Two papers on a potential cancer drug have been retracted following an investigation that found “inappropriate manipulation of bands in gels.”

This makes four retractions by our count for Roman Perez-Soler, an oncologist at the Einstein College of Medicine, and for co-author Yi-He Ling, whose current affiliation is unknown.

Their previous two retractions, which we reported on in 2013, were also for image manipulation. At the time, Perez-Soler told us that Ling “accepted full responsibility for the changes” and he had “returned to his home country.”

The fresh retraction notes, from Molecular Pharmacology, provide a few specifics about the figures that were manipulated this time around.

Continue reading Fourth retraction for Einstein oncologist due to image manipulations

Investigation leads to retraction of breast cancer paper, second for one author

Journal of Biological Chemistry.coverThe authors of a Journal of Biological Chemistry paper on a breast cancer gene are withdrawing it following an investigation at Roswell Park Cancer Institute that found a figure contained “manipulated” data.

Last author Toru Ouchi is based at Roswell in the department of cancer genetics.

Second to last author Sam W. Lee, at Massachusetts General Hospital, lost a Molecular Cell paper in 2013 after some figures were “inappropriately manipulated.”

Here’s the withdrawal note from JBC (which, unusually — but happily so — includes some explanation of what’s wrong with the paper): Continue reading Investigation leads to retraction of breast cancer paper, second for one author

Correction “does not change the scientific meaning” of leukemia letter

blood

The journal Blood has issued a correction in a 2009 letter about the molecular underpinnings of chronic lymphocytic leukemia.

Despite the extent of the changes to a figure, “the error does not change the scientific meaning,” according to the erratum.

The article “p73, miR106b, miR34a, and Itch in chronic lymphocytic leukemia” was written in response to a 2009 Blood paper about the role of a microRNA in CLL. But its western blots were “assembled incorrectly,” leading to duplicated panels. Another set of panels was “shifted.”

So the authors repeated the experiments, and presented them in a correction. Here’s the correction notice in full, published earlier this month, including the figures in question:

Continue reading Correction “does not change the scientific meaning” of leukemia letter

Eighth retraction published for former physiology researcher

International Journal of CancerA lung cancer paper in the International Journal of Cancer has been retracted because of “serious errors related to image duplication.” This marks the eighth retraction for first author, ShouWei Han.

The decision was made by the journal’s editor-in-chief, the publisher Wiley and co-author Jesse Roman (a co-author on Han’s other retracted papers). According to the notice, Han didn’t respond “to requests by the journal or the co-author.”

In 2011, Han was the target of an investigation by his former employer, the University of Louisville in Kentucky. Papers in the Journal of Biological Chemistry, the American Journal of Respiratory Cell and Molecular Biology and American Journal of Physiology: Lung Cellular and Molecular Physiology have been retracted.

Here’s the full retraction notice for the latest retraction:

Continue reading Eighth retraction published for former physiology researcher

Paper on natural ways to fight cancer stem cells nixed for plagiarism

cover (1)Expert Opinion on Therapeutic Patents has retracted a 2015 review article about natural fighters of cancer stem cells for reproducing “content to a high degree of similarity without appropriate attribution or acknowledgement” from a handful of papers.

Although the editor and publisher pulled the paper, they did so with the cooperation of the authors, according to the retraction note: Continue reading Paper on natural ways to fight cancer stem cells nixed for plagiarism

Canadian researchers in legal battle over investigation object to third retraction

The Journal of Clinical InvestigationA third retraction — and a notice of concern — have emerged from the investigation into a husband and wife research team at the University of Toronto that found evidence of faked images and duplicated data.

The problem, according to the latest retraction note for Sylvia Asa and Shereen Ezzat, in the Journal of Clinical Investigation: Portions of the RT-PCR gels “are duplicated in this publication and in a subsequent publication.” That subsequent publication is a 2003 paper that has received a Notice of Concern from the American Journal of Pathology.

According to the retraction note, co-author Gillian E. Wu of York University signed off on the journal’s decision, but Asa, Ezzat and second author Lei Zheng dissented to the retraction. Third author Xian-Feng Zhu couldn’t be reached. Although corresponding author Asa noted that “the initial screen of these samples support the conclusions made in the paper,” the JCI made its position perfectly clear in the note:

Continue reading Canadian researchers in legal battle over investigation object to third retraction

Inquiry into duplications reveals “multiple” image problems in tumor study

STEM_17_1.c1.inddA paper on how abnormal stem cells can cause benign bone tumors has been retracted by Cell Stem Cell after an inquiry into image duplications also uncovered “multiple instances of inappropriate western blot image adjustment.”

The first two authors “declined” to sign the retraction, according to the notice.

Besides confirming initial suspicions that images had been duplicated, the editors also found “multiple instances of inappropriate western blot image adjustment, such as uneven compression of images and removal of background elements:”

Continue reading Inquiry into duplications reveals “multiple” image problems in tumor study

Penn State postdoc faked data in cancer manuscript

oriweb_logoA former postdoctoral fellow at Penn State University faked numerous data and analyses in a manuscript submitted to Molecular Cancer Research, according to the Office of Research Integrity (ORI).

In a notice released today, the ORI found Julie Massè: Continue reading Penn State postdoc faked data in cancer manuscript

UPitt investigation brings total retraction count to four for pair of cancer researchers

Journal of Biological Chemistry1An official inquiry by the University of Pittsburgh has led to two more retractions for a pair of cancer researchers, Tong Wu and Chang Han. By our count, the pair now have four retractions under their belt, all the result of the university investigation.

The Journal of Biological Chemistry published the notices earlier this month, after it was discovered the papers contained cropped panels, among other issues. Importantly, the two papers appear to even have shared some data.

One 2006 paper, “Modulation of Stat3 Activation by the Cytosolic Phospholipase A2α and Cyclooxygenase-2-controlled Prostaglandin E2 Signaling Pathway,” investigated the molecular actors in cancer growth, such as overexpression of cyclooxygenase-2 (COX-2). It has been cited 34 times, according to Thomson Scientific’s Web of Knowledge. Here’s the notice:

Continue reading UPitt investigation brings total retraction count to four for pair of cancer researchers