Finnish institute finds no evidence to support misconduct in diabetes paper

VTT Research CentreAn investigation at the VTT Technical Research Centre of Finland has found no evidence of misconduct by one of its former researchers in a diabetes paper.

We previously reported on the case after the VTT was accused of cutting corners in a previous investigation into Matej Orešič (now based at the Steno Diabetes Center in Gentofte, Denmark)In 2014, the VTT concluded that there was no evidence of falsification or data tampering on the part of Orešič in the 2008 paper published in the Journal of Experimental Medicine (JEM). The proceedings came into the public domain through a news article published in the Finnish media outlet Helsingin Sanomat in February 2016, which prompted the VTT to reopen the case.

Now, the same people who questioned the previous investigation told us they have doubts about the latest conclusions, noting the probe should not have focused on a single paper, but rather on alleged problems within the plasma and serum metabolomics group, previously led by Orešič.

Orešič sent us this report, which the VTT released on June 15, outlining their decision. The VTT confirmed the legitimacy of the report, which says: Continue reading Finnish institute finds no evidence to support misconduct in diabetes paper

Amid controversial Sarepta approval decision, FDA head calls for key study retraction

FDAThe head of the U.S. Food and Drug Administration (FDA) has called for the retraction of a study about a drug that the agency itself approved earlier this week, despite senior staff opposing the approval.

On September 19, the FDA okayed eteplirsen to treat Duchenne muscular dystrophy (DMD), a rare genetic disorder that results in muscle degeneration and premature death. Several of its top officials disagreed with the drug’s approval, questioning how beneficial it will be for patients, as Forbes, MedPage Today and others reported.

In a lengthy report Commissioner Robert Califf sent to senior FDA officials on September 16 — that was made public on September 19 — he called for the retraction of a 2013 study published in Annals of Neurology funded by the seller of eteplirsen, which showed beneficial effects of the drug in DMD patients. Califf writes in the report:

Continue reading Amid controversial Sarepta approval decision, FDA head calls for key study retraction

Researcher in Ireland loses two 13-year old studies

journal-of-biological-chemistryThe Journal of Biological Chemistry (JBC) has retracted two 2003 studies after concluding that figures in the papers had been duplicated, and portions of some figures in one paper “did not accurately represent the results of the experimental conditions.”

The two newly retracted papers have the same last author — Therese Kinsella, a biochemist at the University College Dublin (UCD), who told us the data have been upheld by subsequent research, but that she supports the retractions, which are now part of a UCD investigation.

The retractions will bring up some familiar names: The first author on one of the papers is Sinéad Miggin from Maynooth University in the Republic of Ireland; in 2014, Miggin logged two retractions in the JBC, which triggered an investigation into co-author Aisha Qasim ButtLast year, Maynooth University revoked Butt’s PhD after she admitted to “falsification and misrepresentation” of data in both studies as well as her PhD thesis. At the time, Miggin and two other researchers were fully exonerated by Maynooth University from “any wrongdoing.”

Butt, however, is not an author of either of the newly retracted papers. Although Butt’s LinkedIn page still lists her as a postdoctoral researcher at UCD, a spokesperson from the institution told us she is no longer based there.

We don’t often see such old papers retracted. Kaoru Sakabe, Manager of Publishing Issues at the American Society for Biochemistry and Molecular Biology, which publishes JBC, told us how this decision came about: Continue reading Researcher in Ireland loses two 13-year old studies

Correction cites “unreliable” data in paper by researchers at center of Duke lawsuit

Journal of Biological ChemistryA researcher charged with embezzlement — and now the subject of a multi-million dollar lawsuit — has earned another correction, again citing “unreliable” data.

But this doesn’t appear to be a run-of-the-mill correction notice.

Firstly, it affects a paper co-authored by Erin Potts-Kant and William Foster, former Duke employees now being sued (along with Duke) for including fraudulent data in $200 million worth of federal grants. Secondly, the notice in the Journal of Biological Chemistry is four paragraphs long, and includes six figures — it would normally be considered a “mega-correction.” But lastly, even though the notice is labeled a “correction,” it’s not immediately apparent which aspects of the paper are being changed.

Here are some excerpts from the newest notice: Continue reading Correction cites “unreliable” data in paper by researchers at center of Duke lawsuit

Korean journal bans author for three years for plagiarism

journal-of-the-korean-data-and-information-science-societyA  journal in Korea has banned a researcher from submitting papers for three years after an investigation found evidence of plagiarism.

The retraction notice for “Goodness-of-fit tests for a proportional odds model,” which appears in the Journal of the Korean Data and Information Science Society, cites an investigation by an academic ethics committee, but it’s unclear where this review panel was based. 

Since the original retraction notice is in Korean, we’ve got it translated by One Hour Translation. It reads: Continue reading Korean journal bans author for three years for plagiarism

Two more retractions bring bone researcher’s total to 12

jbmrA bone researcher based in Japan with 10 retractions under his belt has retracted two more papers for similar reasons — problems with the underlying data, and including co-authors who didn’t participate in the project.

In both notices, Yoshihiro Sato is pegged as responsible for the content of the papers. The newly retracted research covers a long timespan — one paper was published in 2000, the other in 2013.

Here’s the first notice, issued by the Journal of Bone and Mineral ResearchContinue reading Two more retractions bring bone researcher’s total to 12

Spanish lab admits to image manipulation, retracts one paper, corrects another

JBCA group has retracted one paper and corrected another in the Journal of Biological Chemistry (JBC) for image manipulations.

Last author José G. Castaño told us the manipulation occurred at the Universidad Autónoma de Madrid, where he and one other co-author are based. He declined to name who was responsible.

Here’s the retraction notice for “Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors:”

Continue reading Spanish lab admits to image manipulation, retracts one paper, corrects another

Author objects to retraction of heart study, implies industry played role

JACC

The Journal of the American College of Cardiology (JACC) has retracted a recently published paper that questioned the effectiveness of a treatment for irregular heartbeat, against the last author’s wishes. 

Andrea Natale, the study’s last and corresponding author and Executive Medical Director of Texas Cardiac Arrhythmia at Austin, took to social media today to express his frustration in the retraction of the July paper, which showed electrical rotors were less effective at fixing irregular heartbeat than other treatments. On Twitter, Natale implied industry played a role in its demise.

However, according to the retraction notice, the paper was felled by problems with randomization; Natale has admitted that some patients were removed from the analysis after one center included them incorrectly.

Here’s the retraction notice for “Impact of Rotor Ablation in Nonparoxysmal Atrial Fibrillation Patients Results From the Randomized OASIS Trial:” Continue reading Author objects to retraction of heart study, implies industry played role

Retraction appears for group whose former member was sanctioned by ORI

Journal of Biological ChemistryResearchers whose former colleague was recently reprimanded by the U.S. Office of Research Integrity (ORI) have retracted a biology paper for duplication.

The retraction includes some familiar names: The last author Steven Grant, senior author of the newly retracted study, is also the last author of 11 papers flagged in a report by the ORI in December, 2015. That report focused on Girija Dasmahapatra, a co-author of the 11 studies who was also based at at Virginia Commonwealth University (VCU). Dasmahapatra left VCU in 2015, and is not listed on the latest retraction.

The retracted paper, published in The Journal of Biological Chemistry (JBC), was also co-authored by Paul Dent, a biochemist at the VCU, who we mentioned last year when he offered to retract another paper in Molecular Pharmacology after concerns arose on PubPeer. The journal has instead issued a lengthy correction (what we call a “mega-correction”).

A VCU spokesperson told us:
Continue reading Retraction appears for group whose former member was sanctioned by ORI

Sting operation forces predatory publisher to pull paper

Medical Archives

Sometimes, the best way to expose a problem with the publishing process is to put it to a test — perhaps by performing a Sokal-style hoax, or submitting a paper with obvious flaws.

In 2014, that’s just what a researcher in Kosovo did. Suspicious that a journal wasn’t doing a thorough job of vetting submissions, she decided to send them an article of hers that had already appeared in another journal. Her thinking was that any journal with an honest and thorough peer review process would hesitate to publish the work. But this journal didn’t — at least at first. Though they retracted the paper this summer, it took a few twists and turns to get there.

The researcher wasn’t the only one wary of the journal — it’s on Jeffrey Beall’s list of “potential, possible, or probable” predatory publishers. Appropriately, Beall recounts the story of her sting operation on his blog. Here’s how it all went down:

Continue reading Sting operation forces predatory publisher to pull paper