Category: by publisher

Early data on potential anti-cancer compound now in human trials was falsified, company admits

A pharmaceutical company has admitted that one of its former researchers falsified early data on a compound that’s designed to fight cancer, now in human trials.

The data, published as an abstract in August 2015 in the journal Cancer Research, reported a therapeutic benefit of acalabrutinib in a mouse model of pancreatic cancer. The compound, developed by the company Acerta Pharma, has also been the subject of additional trials published in the New England Journal of Medicine and Blood in 2015. The 2015 NEJM study, which had several authors in common with the Cancer Research abstract, showed the agent had “promising safety and efficacy profiles in patients” with relapsed chronic lymphocytic leukemia.

But an investigation into the data underlying the 2015 abstract shows some were falsified, prompting the journal to retract the abstract.

Ed Tucker, senior vice president of Medical Safety, Quality and Compliance at Acerta Pharma, told us that in August 2016 the company identified an issue with the data in the Cancer Research abstract and started an investigation:

Continue reading Early data on potential anti-cancer compound now in human trials was falsified, company admits

Nature adds alert to heavily debated paper about gene editing

Nature has added an “editor’s note” to a high-profile August paper alerting readers to the fact that the article has been subject to criticism.

Journals often flag papers that are being debated — what’s unusual here is that the journal doesn’t label the notice as an official “Expression of Concern,” which are indexed by PubMed. Yet the Nature notice reads just like an expression of concern.

Here’s the text of the new notice, which was added October 2 (and spotted by Paul Knoepfler):

Continue reading Nature adds alert to heavily debated paper about gene editing

Second retraction for psychologist reveals clues about culprit behind misconduct

A social psychologist has retracted a second paper that contains “fabricated or manipulated data.”

The first retraction for William Hart at the University of Alabama — also due to data manipulation — appeared earlier this year. The notice raised some questions over authorship: Hart was the sole author, but he blamed the retraction on a graduate student who supplied the problematic data. The questions continued when Hart’s colleagues posted blogs about the problems that occurred in Hart’s lab, using a pseudonym to describe the student, who apparently admitted to fabricating data.  

The author of one of those blogs, Hart’s colleague Alexa Tullett, told us in March that she was retracting another paper she wrote with Hart and the unnamed graduate student. Recently, she confirmed this latest retraction is that paper.

Looking at the author list of the newest retraction, by process of elimination, we now have a lead on the identity of the graduate student who allegedly took responsibility for the misconduct.

Tullett told us:

Continue reading Second retraction for psychologist reveals clues about culprit behind misconduct

Errors in govt database prompt authors to retract and replace paper in JAMA journal

Researchers have retracted and replaced a June 2016 paper in JAMA Internal Medicine after discovering errors in their data.

The paper explored whether Accountable Care Organizations (ACOs) — groups of health care providers who earn more when they deliver high-quality care without boosting costs  — improve care and lower health care costs for Medicare patients. The paper’s corresponding author, Carrie H. Colla, and her colleagues examined Medicare data over five years and found the ACOs provided “ modest savings on average”  and less hospital care.  

But the data from the Centers for Medicare & Medicaid Services (CMS) contained errors. According to Colla, after the paper was published, CMS “let us know in the fall [2016] that there were errors in the files, but weren’t able to give us final replacement files until winter.” Continue reading Errors in govt database prompt authors to retract and replace paper in JAMA journal

So, was it plagiarism? Journal retracts three papers over “citation and attribution errors”

When several recent submissions raised a red flag, a pediatrics journal decided to investigate. The journal, Pediatrics in Review, discovered “citation and attribution errors” in three case studies, which the journal has now retracted.  

Luann Zanzola, the managing editor of the journal, explained that the editors caught the errors when they scanned the three papers—one published in 2014 and two in 2015—using the plagiarism detection software, iThenticate. Zanzola told us that the three case studies “were flagged for high iThenticate scores,” and when the authors could not adequately explain the amount of text overlap, the editors retracted the papers.

The retraction notices for the three papers, published in the journal’s September 2017 issue, are identical: Continue reading So, was it plagiarism? Journal retracts three papers over “citation and attribution errors”

Journal adds concern notice to paper by psychologist Jens Förster

A social psychology journal has added an expression of concern to a paper by prominent social psychologist Jens Förster, whose work has been subject to much scrutiny.

This is the latest in a long-running saga involving Förster. The 2012 paper in the Journal of Experimental Social Psychology had been flagged by a 2015 report describing an investigation into Förster’s work, which had concluded the paper likely contained unreliable data. Several other papers that received similar designations in that report have either been retracted or received expressions of concern (EoC).

The (paywalled) notice provides a lengthy explanation for why the journal chose to add an EoC, rather than retract the paper, as the University of Amsterdam had recommended. Here is an excerpt:

Continue reading Journal adds concern notice to paper by psychologist Jens Förster

Authors retract plant biology paper after they realized sample was contaminated

Plant biologists from China have retracted a 2013 paper in The Plant Cell after discovering that some of the plant material used was “inadvertently contaminated.”

According to the retraction notice, the authors believe the contamination affects the main conclusion of their paper. Continue reading Authors retract plant biology paper after they realized sample was contaminated

Miffed at exclusion from a meta-analysis, researcher writes own “expression of concern”

On June 10, Psycho-Oncology, a journal that publishes research on the “psychological, social, behavioral, and ethical” side of cancer, received a complaint.

In a letter, Ad Kaptein, a researcher at the Leiden University Medical Centre, in the Netherlands, wrote to say that a review and meta-analysis published by the journal that month hadn’t adequately cited the relevant literature in the field, including seven studies co-authored by Kaptein himself. The authors of the original paper say they had considered citing Kaptein’s work but decided against it, for various reasons.

The journal considered Kaptein’s complaint valid enough to publish his letter. But the letter carries the title “Expression of concern” — a term usually reserved for editorial notices issued by the journal to warn readers about some aspects of an article. But in this case, the author supplied the term, not the journal — yet the letter is tagged as an Expression of Concern on PubMed, giving the impression the paper has received a formal editorial notice.

Journal Co-Editor Maggie Watson told Retraction Watch:

Continue reading Miffed at exclusion from a meta-analysis, researcher writes own “expression of concern”

“No wrongdoing had occurred,” says Karolinska, following investigation of cancer research

A journal has removed an expression of concern for a 2011 paper after Karolinska Institutet (KI) “concluded no wrongdoing had occurred.” 

In June, Journal of Cell Science (JCS) issued the expression of concern, after a reader contacted the editors with questions about the data in one of the figures. JCS investigated but could not resolve the issue, and in March 2017 turned the case over to KI where the authors are based.

The 2011 paper had already received a correction in 2016, citing inadvertent figure duplication.

In late August, KI concluded its investigation into the 2011 paper by last author Boris Zhivotovsky; JCS has now updated the expression of concern with a publisher’s note: Continue reading “No wrongdoing had occurred,” says Karolinska, following investigation of cancer research

Nature tags glacier paper with note of concern due to data mix-up

Nature has tagged a recent paper on the importance of glacial melt to water supply in Asia with an expression of concern (EoC), after receiving a tip that the author had misused some data.

The EoC for “Asia’s glaciers are a regionally important buffer against drought,” published by Hamish Pritchard, a glaciologist at the British Antarctic Survey, came out today. The May 11, 2017 article — which has been cited three times, according to Clarivate Analytics’ Web of Science — considers the contribution of glaciers to water supply in Central Asia and the potential for glacier loss to exacerbate water stress in the region. The paper received limited news coverage when it came out from science sites, including Phys.org.

Pritchard appears to have improperly used a particular data set — an error that was reported to the journal by two outside experts within weeks after the paper was published.  Continue reading Nature tags glacier paper with note of concern due to data mix-up