Category: cancer research

Former UAB natural products researcher up to a dozen retractions

Santosh Katiyar

A researcher who studied natural products for cancer at the University of Alabama, Birmingham (UAB), had six papers retracted last month, bringing him to a total of 12.

Four of the recently retracted papers by Santosh Katiyar had appeared in PLOS ONE, and two had been published in Cancer Research. They have together been cited more than 250 times, according to Clarivate Analytics’ Web of Science, and are on subjects including compounds found in grape seeds and green tea.

Here’s an example, from PLOS ONE, for “Green Tea Catechins Reduce Invasive Potential of Human Melanoma Cells by Targeting COX-2, PGE2 Receptors and Epithelial-to-Mesenchymal Transition:” Continue reading Former UAB natural products researcher up to a dozen retractions

Former University of Maryland cancer researcher up to 21 retractions

Anil Jaiswal

Anil Jaiswal, who until a year ago was a cancer researcher at the University of Maryland, Baltimore, has had four more papers retracted.

That makes 21 for Jaiswal, who joins our leaderboard of the 30 researchers with the most retractions. All four new retractions appear in journals published by the American Association for Cancer Research, and are for image or data manipulation.

For example, here’s the retraction notice for “Aromatase Inhibitor–mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer,” in Molecular Cancer Therapeutics: Continue reading Former University of Maryland cancer researcher up to 21 retractions

Researcher who once tried to sue critics has another dozen papers retracted

Fazlul Sarkar

A cancer researcher who went to court — unsuccessfully — claiming that commenters on PubPeer had cost him a new job has just lost another 12 papers.

The twelve now-retracted papers by Fazlul Sarkar and colleagues — as well as another by Sarkar that is now subject to an editor’s note — all appeared in Cancer Research, which made for a long table of contents in its September 15 issue. Continue reading Researcher who once tried to sue critics has another dozen papers retracted

Cancer journals retract 10 papers, flag 8 more, and apologize for the delay

Bharat Aggarwal

Five journals published by a prominent cancer research society have retracted a total of 10 papers — most of them by a former researcher at the MD Anderson Cancer Center in Houston.

Nine of the 10 retractions share that researcher, Bharat Aggarwal, as an author. Aggarwal — who more than five years ago threatened to sue us for reporting on an investigation into his work — is now up to 28 retractions, and has left his post at MD Anderson. The AACR is also appending an editor’s note to eight of his other papers — but it has not explained the reason for what it acknowledges is a lag in moving on these articles.

“Unfortunately, we have been delayed in correcting the published record, and for this we apologize,” writes the publisher of The American Association for Cancer Research (AACR), Christine Rullo, in a note in this month’s issue of Cancer Research. Rullo doesn’t say how long the journals took to handle the retractions. Continue reading Cancer journals retract 10 papers, flag 8 more, and apologize for the delay

Nearly two years after a university asked for retractions, two journals have done nothing

How long should a retraction take?

That’s a complex question, of course, depending on how long the alleged issues with a paper take to be investigated, whether authors — and their lawyers — fight tooth-and-nail against a retraction, and other factors. But once a university officially requests a retraction, how long should one take?

The answer, for two journals who published work by cancer researcher Anil Jaiswal, is 22 months — and counting. Continue reading Nearly two years after a university asked for retractions, two journals have done nothing

Early data on potential anti-cancer compound now in human trials was falsified, company admits

A pharmaceutical company has admitted that one of its former researchers falsified early data on a compound that’s designed to fight cancer, now in human trials.

The data, published as an abstract in August 2015 in the journal Cancer Research, reported a therapeutic benefit of acalabrutinib in a mouse model of pancreatic cancer. The compound, developed by the company Acerta Pharma, has also been the subject of additional trials published in the New England Journal of Medicine and Blood in 2015. The 2015 NEJM study, which had several authors in common with the Cancer Research abstract, showed the agent had “promising safety and efficacy profiles in patients” with relapsed chronic lymphocytic leukemia.

But an investigation into the data underlying the 2015 abstract shows some were falsified, prompting the journal to retract the abstract.

Ed Tucker, senior vice president of Medical Safety, Quality and Compliance at Acerta Pharma, told us that in August 2016 the company identified an issue with the data in the Cancer Research abstract and started an investigation:

Continue reading Early data on potential anti-cancer compound now in human trials was falsified, company admits

UCSF, VA investigations find “clear evidence” of misconduct in cancer papers

Earlier this year, the University of California, San Francisco and the San Francisco Veterans Administration Medical Center teamed up to write a letter.

Addressed to the editorial office at the American Association of Cancer Research (AACR), the letter, parts of which have been published in a retraction notice, contained information concerning two papers on genetic risk factors for a type of kidney cancer and a type of uterine cancer, respectively, published in different AACR journals over a decade ago by researchers affiliated with the institutions.

The papers had been at the center of research misconduct investigations at both UCSF and the VA and the investigations came to the conclusion that both papers contained:

fabrication or falsification of data that constitutes Research Misconduct.

Though one of the papers has been retracted, it’s unclear what will happen to the other. [Note: See update at the bottom of the post.] Continue reading UCSF, VA investigations find “clear evidence” of misconduct in cancer papers

Drip, drip: UCLA investigation finds more image duplications

Image duplications and unsupported data continue to plague a network of cancer researchers that includes the former vice chancellor for research at the University of California, Los Angeles, James Economou.

On July 2, the editors at Cancer Research retracted a 2011 paper that Economou published as last author, saying it suffered from image duplication and unsupported figures. This is the second retraction we’re aware of to come out of an investigation by UCLA’s Office of Research Policy and Compliance that has touched this group of scientists.

Here’s the notice for “Molecular Mechanism of MART-1+/A*0201+ Human Melanoma Resistance to Specific CTL-Killing Despite Functional Tumor–CTL Interaction,” which says the retraction comes at the request of UCLA: Continue reading Drip, drip: UCLA investigation finds more image duplications

A university asked for numerous retractions. Eight months later, three journals have done nothing.

Anil Jaiswal

When journals learn papers are problematic, how long does it take them to act?

We recently had a chance to find out as part of our continuing coverage of the case of Anil Jaiswal at the University of Maryland, who’s retracted 15 papers (including two new ones we recently identified), and has transitioned out of cancer research. Here’s what happened.

As part of a public records request related to the investigation, we received letters that the University of Maryland sent to 11 journals regarding 26 “compromised” papers co-authored by Jaiswal, four of which had been retracted by the time of the letter. The letters were dated between August and September 2016 (and one in February) — although, in some cases, the journals told us they received the letter later. Since that date, three journals have retracted nine papers and corrected another, waiting between four and six months to take action. One journal published an editorial note of concern within approximately two months after the university letter.

And six journals have not taken any public action.

Continue reading A university asked for numerous retractions. Eight months later, three journals have done nothing.

Cancer researcher earns 3 more retractions following NIH misconduct investigation

A researcher formerly based at the National Cancer Institute has earned three new retractions following an investigation that found she committed misconduct.

In May of last year, Stephanie Watkins, who now works at Loyola Medicine, earned one two retraction, which mentions a review by an investigation committee at the National Institutes of Health. Two of the new notes, published in Cancer Research, mention the review as well, and cite data falsification in a figure as the reason for retraction. Watkins is the only author that did not agree to those retractions.

There may be more changes to the literature — an editor at another cancer journal told us the journal is awaiting a decision from the Office of Research Integrity before deciding what to do with a paper by Watkins, given that she does not agree with the misconduct charges.

We’ll start with a retraction note from Cancer Research:

Continue reading Cancer researcher earns 3 more retractions following NIH misconduct investigation