Emory looking into circumstances of three new retractions in the JBC

Emory University is looking into why the Journal of Biological Chemistry (JBC) has retracted three papers published by Emory faculty from 2005 to 2007, Retraction Watch has learned. The papers were: Continue reading Emory looking into circumstances of three new retractions in the JBC

Second retraction by Harvard group studying cannabinoids, this one in JBC

Last week, we reported that a group of Harvard researchers had retracted a paper in Blood for “multiple instances of duplicate (redundant) publication of data, text, and images that are nonessential to the paper.” The retraction notice referred to a paper in the Journal of Biological Chemistry (JBC):

The redundancies are between the above-cited Blood article and the following 12 November 2010 article, published in the Journal of Biological Chemistry (JBC): Jiang S, Zagozdzon R, Jorda MA, et al. Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. J Biol Chem. 2010;285(46):35471-35478.

Today, we learned that the JBC paper has also been retracted. The notice, as we’ve come to expect from the JBC, is unhelpful: Continue reading Second retraction by Harvard group studying cannabinoids, this one in JBC

“Nonessential” duplication leads to retraction of Blood cannabinoid paper

The journal Blood has retracted a paper from a group of prestigious Harvard researchers after the article, which appeared in January 2011, was found to have multiple instances of material — text, data and other elements — that had appeared in a previous publication from several of the authors.

The article was titled “Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.” Its authors included Hava Avraham, a noted cancer researcher, and Jerome Groopman, known for his New Yorker articles about medicine and, scientifically, for his work on cannabinoids and cancer, among other areas.

According to the retraction notice: Continue reading “Nonessential” duplication leads to retraction of Blood cannabinoid paper

Anil Potti resurfaces at South Carolina cancer center

courtesy Duke

Anil Potti, the oncologist who has been forced to retract four papers because of results that could not be reproduced, and resigned last fall from Duke, has a new job. He’s joined the Coastal Cancer Center, an oncology practice with four offices in South Carolina and one in North Carolina.

The Duke Fact Checker was apparently the first to report the news. The Cancer Letter, which has been out front on the Potti story for a year, first reported the news.*

It’s not surprising that Potti’s Coastal Center bio leaves out any mention of his troubled research and the fact that he faked a Rhodes scholarship on a grant application. Investigations into what happened at Duke are ongoing. Continue reading Anil Potti resurfaces at South Carolina cancer center

The Importance of Being Reproducible: Keith Baggerly tells the Anil Potti story

For those Retraction Watch readers who have been following the case of Anil Potti — who has now retracted four papers — Keith Baggerly’s name will likely be familiar. Baggerly is the bioinformatician at M.D. Anderson in Houston who has been publicly questioning, in letters, papers, and The Cancer Letter, work by Potti et. al.

Yesterday, Baggerly gave a keynote at the Council of Science Editors meeting in Baltimore. It was a fascinating — and riveting — walk through how, after a group at M.D. Anderson asked him and his team to evaluate the Potti group’s tools for predicting whether given patients would respond to different chemotherapies, Baggerly’s group unraveled the Potti research.

In his talk, Baggerly demonstrated all of the mislabeling and other easily recognized errors his team found when they sifted through the raw data. And yet there were a number of wince-inducing moments in which Baggerly described the cool reception he had from several journals.

There have been a lot of calls recently that journals should require that authors deposit their data.  There’s none more powerful than when they come at the end of a talk showing how that could have stopped a faulty clinical trial from ever starting.

Baggerly told Retraction Watch he just wants this story to get the widest attention possible, so he was glad to allow us to post his slides. They get appropriately technical, given the crowd, but it’s worth it. You can follow a very unofficial and rough transcript at this Twitter search, since Ivan live-tweeted the talk. Or just click over to the slideshow here.

Data fraud at Emory leads to retractions of three cardiology papers

An investigation by Emory University in Atlanta has led to the retractions of three articles containing falsified data, but the ambiguous wording of the notices leaves us wondering if they are implying more than they state.

Two of the papers appeared in the journal Arteriosclerosis, Thrombosis, and Vascular Biology. The notices in ATVB implicate a researcher named Lian Zuo, who worked in Emory’s division of cardiology.

Here’s one: Continue reading Data fraud at Emory leads to retractions of three cardiology papers

Science publishes replication of Marc Hauser study, says results hold up

There has been some news over the past few weeks about Marc Hauser, the Harvard psychologist found guilty of misconduct by the university last year. First, because Harvard had listed him in a course catalog, The Crimson said that he might be teaching again, following a ban. But that turned out not to be the case, as The Boston Globe reported.

Today, Science lifted the embargo on a paper by Hauser and Justin Wood, now of the University of Southern California, showing that results published in the journal in 2007 — and later questioned — have held up. The abstract: Continue reading Science publishes replication of Marc Hauser study, says results hold up

Another retraction of Spirocor research

Remember Spirocor, the Israeli company that closed down a clinical trial involving its “respiratory stress” test for coronary artery disease because the data underpinning the validity of the method proved unreliable? The problem led to the retraction of two articles, about which we’ve previously reported. But we also found a study by some of the same researchers, who include scientists in Israel and the United States, that had been presented at the 2010 meeting of the American Heart Association and published in the journal Circulation.

That abstract, No. 14426 “Accuracy and Usefulness of Finger Pulse Wave Analysis during Brief Deep Breathing Exercise (Respiratory Stress Response) as a Marker of Significant Coronary Artery Disease,” has now been retracted — making, to our knowledge, the entire body of published research on the Spirocor product an editorial memory.

Here’s the notice, which appears within the text of the abstract: Continue reading Another retraction of Spirocor research

In a retraction’s wake: Postdoc Shane Mayack, dismissed from Amy Wagers’ stem cell lab, speaks out

 

Last October, Retraction Watch readers will recall, up-and-coming stem cell researcher Amy Wagers retracted a study in Nature describing how her team rejuvenated blood-forming stem cells in older mice. Shane Mayack, a postdoc in Wagers’ lab who had been dismissed after an inquiry into what happened, did not sign that retraction. Since then, Mayack has not spoken to the press, except for a brief comment to Nature through her attorney.

Here, we present, unedited, Mayack’s side of the story. While accepting responsibility, she also has a number of suggestions for how universities and journals can handle these situations better. Shane can be reached at smayck[at]yahoo.com.

Since it was well covered by this blog, the readers of Retraction Watch are no doubt aware that in October 2010, a paper that I co-authored was retracted from Nature and a notice of concern was posted regarding a second paper published in Blood.

So, what went wrong? Continue reading In a retraction’s wake: Postdoc Shane Mayack, dismissed from Amy Wagers’ stem cell lab, speaks out

NEJM retracts Potti paper

courtesy Duke

About a month ago, the New England Journal of Medicine told us that they didn’t “have any plans” to retract a paper by Anil Potti. Apparently, they’ve changed their minds.

Today, they posted this retraction notice: Continue reading NEJM retracts Potti paper