Category: israel retractions

JCI retracts paper by stem cell biologist Jacob Hanna, citing “figure irregularities”

jciapril2015The Journal of Clinical Investigation has retracted a 2004 paper by Jacob Hanna, a highly cited stem cell researcher in Israel whose work has been dogged by questions about its validity.

Questions about the work, and other articles on which Hanna was an author, were raised on PubPeer last November. This is his first retraction.

The retraction stems from “a number of figure irregularities;” the authors say they were “inadvertently introduced,” and subsequent work has supported their data and conclusions. However, due to the “number of serious mistakes,” the JCI editorial board chose to retract the article. Hanna and corresponding author Ofer Mandelboim at The Lautenberg Center for General and Tumor Immunology — part of Hebrew University, in Jerusalem, where Hanna used to work — say they have accepted the decision.

Hanna, currently at the Weizmann Institute of Science, studies ways to reprogram cells to become more versatile stem cells. He also spent time as a postdoc at the Whitehead Institute in Cambridge and Mount Sinai, in New York City.

Six of Hanna’s papers have been cited more than 500 times, according to Thomson Scientific’s Web of Knowledge. The most-cited, with more than 1,000 citations, was a 2008 Nature paper.

The retracted article, “Novel APC-like properties of human NK cells directly regulate T cell activation,” has been cited 121 times, according to Thomson Scientific’s Web of Knowledge.

The retracted paper examined the early steps of an immune response involving natural killer (NK) cells and antigen-presenting cells (APCs). From the abstract: Continue reading JCI retracts paper by stem cell biologist Jacob Hanna, citing “figure irregularities”

Stem cell researcher Jacob Hanna responds to criticism

Jacob Hanna
Jacob Hanna

Over the past few months, there has been a great deal of criticism of the work of stem cell researcher Jacob Hanna, especially on PubPeer.

Now, Hanna has responded in the comments of the PubPeer entries for a number of papers. He has also posted a number of PDFs, including his PhD thesis, and correspondence with scientists who have been critical of his work.

He also wrote a response to a criticism published on bioRxIV, a non-peer reviewed repository of biology pre-prints.

One of Hanna’s comments on PubPeer is a summary of the issues with his Blood paper on PubPeer, blaming the figure errors on “medical trainees” who did the word while he was away at Mount Sinai. Here’s his explanation:  Continue reading Stem cell researcher Jacob Hanna responds to criticism

Retractions follow revelations of misconduct by diabetes biotech

diabetes careSeveral months after a drug company cancelled development of a potential diabetes cure because it found evidence that a biotech they had recently acquired had committed misconduct in studies of the drug, two retractions of relevant studies have appeared.

The research involves DiaPep277, which, as Josh Levy explained here in September, “would cause the immune system to stop attacking beta cells,” the cells in the pancreas that produce insulin. But Hyperion Therapeutics, which had acquired DiaPep277 developer Andromeda Biotech in June, announced in September that it had

uncovered evidence that certain employees of Andromeda Biotech, Ltd., which Hyperion acquired in June 2014, engaged in serious misconduct, including collusion with a third-party biostatistics firm in Israel to improperly receive un-blinded DIA-AID 1 trial data and to use such data in order to manipulate the analyses to obtain a favorable result.

The retractions are both of papers published in Diabetes Care in May 2014. Here’s the notice for “Treatment of Recent-Onset Type 1 Diabetic Patients With DiaPep277: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial:” Continue reading Retractions follow revelations of misconduct by diabetes biotech

Stem cell researcher Hanna “working…to correct the unfortunate and inadvertent mistakes” in papers

jacob
Jacob Hanna

Jacob Hanna of Israel’s Weizmann Institute has been a media darling for years, including as a member of the 2010 Technology Review 30 under 35 for his work with stem cells.

However, questions have been mounting about his research, both on PubPeer (which has critical comments for 15 papers he’s an author on) and in other stem cell labs, who have not been able to reproduce much of Hanna’s work.

We asked Hanna about a PubPeer entry specific to a 2005 paper in Blood. Commenters have accused the authors of figure manipulation and possible data republication. Here’s a figure from that post: Continue reading Stem cell researcher Hanna “working…to correct the unfortunate and inadvertent mistakes” in papers

Blatant plagiarism sinks paper (and earns a sabbatical!) for mathematician

Image via Akash Kataruka
Image via Akash Kataruka

You know it’s a good one when it makes it onto the Wikipedia page for “scientific misconduct.”

On April 21, the International Journal of Pure and Applied Mathematics retracted two 2008 papers by scientist Alexander Spivak of Holon Institute of Technology in Israel. In September, the journal updated the notice to explain why: The papers both contained copy/pasted chunks from a 2001 paper by Spivak’s post-doc boss at Tel Aviv University, Zeev Schuss, and two other authors.

The tipster seems to have been Schuss himself, who told us about his role in the unravelling of the fraud: Continue reading Blatant plagiarism sinks paper (and earns a sabbatical!) for mathematician

JCI retracts 10-year-old cancer study because figures were “intentionally mislabeled”

jci june 14The Journal of Clinical Investigation is retracting a 2004 paper by a cancer researchers from Italy because of “evident misrepresentation of data and image duplication.”

Here’s the notice for “The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies:” Continue reading JCI retracts 10-year-old cancer study because figures were “intentionally mislabeled”

Zero dark thirty for Al-Qaeda article

ftpv20.v026.i01.coverAn Israeli terrorism scholar has lost a review of a 2011 book on Al-Qaeda because he published it twice in different outlets.

The researcher, Isaac Kfir, is with the International Institute for Counter- Terrorism, where he studies

issues relating to post-conflict reconstruction (security issues) and transitional justice (restorative and retributive justice). His other research looks at the effect of Islamic radicalism within the Arab-Israeli conflict.

The book in question is Al-Qaeda: From Global Network to Local Franchise, by Christina Hellmich of the University of Reading in the UK. The offending article appeared in Terrorism and Political Violence, a Taylor & Francis title. According to the notice: Continue reading Zero dark thirty for Al-Qaeda article

A double-bill from Digestive Diseases and Sciences, both for regurgitation — aka duplication

ddsComing back up?

Digestive Diseases and Sciences has retracted two papers for duplication.

The first paper, “Membrane-Bound Mucins and Mucin Terminal Glycans Expression in Idiopathic or Helicobacter pylori, NSAID Associated Peptic Ulcers,” was published in October 2012 by a group from Israel and the United States. It found that:

Cytoplasmic MUC17 staining was significantly decreased in the cases with idiopathic ulcer. The opposite was demonstrated for MUC1. This observation might be important, since different mucins with altered sialylation patterns likely differ in their protection efficiency against acid and pepsin.

But, as the retraction notice suggests, that much had been found before: Continue reading A double-bill from Digestive Diseases and Sciences, both for regurgitation — aka duplication

A new record? 27-plus years later, a notice of redundant publication

royal society bA 1984 paper in Philosophical Transactions of The Royal Society B is now subject to a notice of redundant publication because a lot of it had been published in Cell the same year.

Whether 28 years — 27 years and 9 months, to be precise — is any kind of official record is unclear, since we haven’t really kept track of notices of redundant publication. It would, however, beat the record for longest time between publication and retraction, 27 years and one month.

Here’s the notice, which ran in September of last year but just came to our attention: Continue reading A new record? 27-plus years later, a notice of redundant publication

Environmental engineer loses paper after co-authors say he didn’t have permission to publish it

j chem tech biotechAn environmental engineer at Israel’s Ben-Gurion University has been forced to retract a paper amid an ethics committee investigation into whether he had the right to publish it.

The Journal of Chemical Technology and Biotechnology retracted a study from the Vitaly Gitis lab just months after its publication: Continue reading Environmental engineer loses paper after co-authors say he didn’t have permission to publish it