Author: Ivan Oransky

Patient database errors lead to three rheumatology retractions

The authors of three papers in Rheumatology International about systemic sclerosis, also known as scleroderma, are retracting them after patients were misidentified in databases. According to the three notices:

This article has been retracted at the request of the authors. The authors made a serious statistical error which unfortunately invalidates their results.

Corresponding author Metin Isik tells Retraction Watch that the error was adding a patient with systemic sclerosis database twice, and adding another patient with polymyositis, not systemic sclerosis, to the sclerosis database. (Why the journal didn’t spell that out in the notice is anyone’s guess, but we’ve asked the editor for comment and will update with anything we hear back.)

It’s easy to see how three patients would affect the results of “Systemic sclerosis and malignancies after cyclophosphamide therapy: a single center experience,” Continue reading Patient database errors lead to three rheumatology retractions

The HeLa problem: What a retraction says about whether cancer researchers can trust their cell lines

Retraction Watch readers who’ve read Rebecca Skloot’s bestseller The Immortal Life of Henrietta Lacks may remember that decades ago, scientists began realizing that Lacks’s cells, now known as the HeLa cell line and used in labs around the world, were so good at proliferating that they had taken over many other cell lines researchers use to study human disease.

Such readers would have been nodding their heads at a front-page Wall Street Journal on Saturday. As Amy Dockser Marcus (no relation to Adam) reports: Continue reading The HeLa problem: What a retraction says about whether cancer researchers can trust their cell lines

A retracted periodontitis-heart disease paper that didn’t make it into the new AHA review

On Wednesday, the American Heart Association announced something that those of us who’d been reading the medical literature carefully had known for a while: Bad gums do not cause heart disease.

Periodontitis is linked to bad heart disease, you see, as studies have shown, and periodontists have sure been using this as an excuse to tell us to floss. But there’s never been a convincing study showing that one causes the other.

In fact, it’s not even clear how you’d do that study. “Let’s see, for a control group, we should have 100 people convince themselves they’re flossing for a year, but not actually floss….oh, what else can we get funding for?”

That “news” prompted an email from Retraction Watch friend Marc Abrahams, Continue reading A retracted periodontitis-heart disease paper that didn’t make it into the new AHA review

Math paper retracted because it “contains no scientific content”

Have a seat, this one’s a howler.

According to a retraction notice for “Computer application in mathematics,” published in Computers & Mathematics with Applications: Continue reading Math paper retracted because it “contains no scientific content”

ORI sanctions Oregon eye stem cell researcher for faking data in grant applications

Peter Francis

Peter Francis, a former Oregon Health Sciences University (OHSU) eye researcher, has been sanctioned by the U.S. Office of Research Integrity (ORI) for claiming, in grant applications, to have performed experiments that he hadn’t actually done.

According to ORI’s case summary, Francis Continue reading ORI sanctions Oregon eye stem cell researcher for faking data in grant applications

Salzburg University fires crystallographer Robert Schwarzenbacher for faking data in Journal of Immunology paper

Robert Schwarzenbacher

The crystallographer who confessed to data fabrication that has forced the retraction of a structure in a Journal of Immunology paper on birch pollen allergen — but later recanted — has been fired by the University of Salzburg.

Robert Schwarzenbacher, 39, was awarded a 1.7 million-euro Marie Curie fellowship, the highest individual European research award, six years ago. According to Salzburg’s ORF.at: Continue reading Salzburg University fires crystallographer Robert Schwarzenbacher for faking data in Journal of Immunology paper

Group investigated by University of Louisville corrects lung cancer paper after retracting six others

A group of researchers whose work has been under investigation at the University of Louisville has issued a correction for a paper in the American Journal of Respiratory Cell and Molecular Biology (AJRCMB).

The correction follows three retractions each in the Journal of Biological Chemistry and the AJRCMB, the latter of which made it clear that lab member ShouWei Han was responsible for the manipulations and duplications that brought down the papers. Here’s the new notice, which appeared in the March 1, 2012 issue of the journal: Continue reading Group investigated by University of Louisville corrects lung cancer paper after retracting six others

Endocrinologist Shigeaki Kato resigns amidst University of Tokyo misconduct investigation

Shigeaki Kato

Shigeaki Kato, an endocrinology researcher at the University of Tokyo who retracted a paper late last month, has resigned amidst an investigation into whether he committed misconduct, Japanese media outlets are reporting.

According to the reports, the university has been investigating Shigeaki Kato and his group, affiliated with the Institute of Molecular and Cellular Biosciences, for scientific misconduct. The investigation was prompted by an outside whistleblower’s allegations in January about 24 of Kato’s papers. The whistleblower claimed that the papers manipulated and reused data improperly, and created a YouTube video to spread the word, as ScienceInsider reported earlier this year.

One of the 24 papers, Continue reading Endocrinologist Shigeaki Kato resigns amidst University of Tokyo misconduct investigation

Third retraction arrives for Alirio Melendez, this one in the Journal of Cellular Physiology

Alirio Melendez, the former National University of Singapore researcher who has already retracted two papers in the midst of an investigation into about 70 of his publications, has had a third retracted a third.

Here’s the notice from the Journal of Cellular Physiology: Continue reading Third retraction arrives for Alirio Melendez, this one in the Journal of Cellular Physiology

Can we trust Western blots?

The title of this post is the headline of our latest column for LabTimes. It’s inspired by a number of animated discussions on Retraction Watch following our coverage of various Western blot problems — some unintentional, and some, well, less so.

Take, for example, this comment, which we quote in the column: Continue reading Can we trust Western blots?