Retraction Watch

Tracking retractions as a window into the scientific process

Archive for the ‘molecular cancer therapeutics’ Category

2014 ORI finding results in retraction of cancer paper with manipulated images

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Mol Can TherA paper flagged in an Office of Research Integrity notice more than one year ago has finally been retracted. According to the notice, the paper includes images manipulated by author H. Rosie Xing, a former University of Chicago cancer researcher.

The main conclusions of the paper are affected by the ORI finding, according to the retraction note from Molecular Cancer Therapeutics. But otherwise, the note contains information that was available in the ORI finding, published in December 2014.

Pharmacologic Inactivation of Kinase Suppressor of Ras1 Sensitizes Epidermal Growth Factor Receptor and Oncogenic Ras-Dependent Tumors to Ionizing Radiation Treatment” has been cited seven times, according to Thomson Scientific’s Web of Knowledge — twice since the ORI finding came out.

The retraction note explains which images were affected by the manipulation:

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Cancer researcher contributed “false data” to 11 studies

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ori-logoA former cancer researcher has falsified data in 11 studies, according to the results of a investigation scheduled to be published in the Federal Register tomorrow.

The Office of Research Integrity’s findings are based on an inquiry at Virginia Commonwealth University, where Girija Dasmahapatra worked until July of this year, investigating possible therapies for cancer. The misconduct affected research funded by three grants from the National Institutes of Health. Steven Grant, a researcher at VCU, is the principal investigator on the grants, each of which total over $2 million in funding. All of the 11 affected papers will be corrected or retracted, according to the ORI notice.

Two of the papers containing “falsified and/or fabricated” data — a study on an experimental combination of drugs for blood cancer and one on chemotherapies for rare forms of lymphoma  — were covered in press releases by VCU.

According to the notice in the Federal Register:

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ORI sanctions former University of Chicago and UCSF scientists for faking findings

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H. Rosie Xing

H. Rosie Xing

The stories behind several recent inscrutable retraction notices became a bit more clear today when the Office of Research Integrity (ORI) issued findings in cases involving former researchers at the University of Chicago and the University of California, San Francisco.

The ORI found that H. Rosie Xing, a former assistant professor at the University of Chicago, Read the rest of this entry »

A “retraction in part” for Anil Potti and colleagues, in Molecular Cancer Therapeutics

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A partial retraction has joined the ten retractions and five corrections of Anil Potti’s papers, this one of a 2008 paper in Molecular Cancer Therapeutics. The move comes 14 months after the retraction of the Nature Medicine paper upon which much of the Molecular Cancer Therapeutics paper was based.

Here’s the notice: Read the rest of this entry »