‘The problem is that there is no IL-26 gene in the mouse’ — an exasperated letter leads to a retraction

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A group of ophthalmology researchers in China got caught trying to pull the wool over the eyes of readers by falsely claiming to have used a therapy that doesn’t exist. 

As its title would indicate, the article, “Anti-angiogenic effect of Interleukin-26 in oxygen-induced retinopathy mice via inhibiting NFATc1-VEGF pathway,” by a team from Jinhua Municipal Central Hospital in Zhejiang, purported to show that IL-26 could prevent the growth of new blood vessels in mice with damaged retinas. 

Per the abstract of the paper, which appeared in Biochemical and Biophysical Research Communications (BBRC): 

Continue reading ‘The problem is that there is no IL-26 gene in the mouse’ — an exasperated letter leads to a retraction

Hepatitis expert up to five retractions and one expression of concern denies reusing images

Gulam Waris

A microbiology journal has issued an expression of concern over image reuse in a 2010 paper whose senior author has already racked up five retractions for duplicating figures. 

The article, “Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway,” appeared in the Journal of General Virology, a publication of the Microbiology Society. The last author of the paper is Gulam Waris, an expert in viral hepatitis who is on the faculty of the Rosalind Franklin University of Medicine and Science in North Chicago. The paper has been cited 75 times, according to Clarivate Analytics’ Web of Science. 

By our count, Waris — whose work has made several appearances in PubPeer — has lost at least five papers to retraction for image duplication and questionable data. 

Continue reading Hepatitis expert up to five retractions and one expression of concern denies reusing images

Paper used to support ban on Caster Semenya competing earns massive correction

Caster Semenya

The authors of a controversial paper on what constitutes “normal” hormone levels in men and women  — and, by implication, “male” and “female” athletes — are set to issue a massive correction of the work, Retraction Watch has learned. But an outside, albeit not disinterested, researcher who prompted the correction says the correction itself is amiss. 

The article, “Large divergence in testosterone concentrations between men and women: frame of reference for elite athletes in sex-specific competition in sports, a narrative review,” appeared earlier this year in Clinical Endocrinology, a Wiley title. The authors of the meta-analysis, led by Richard Clark, of the US Anti‐Doping Agency, argued that testosterone levels between the sexes do not overlap in the absence of chromosomal or genetic anomalies that blur the distinction between male and female. 

That finding was cited recently by an architect of the International Association of Athletics Federations’ decision to bar the South African trackstar, Caster Semenya, and other “hyperandrogenic” women (Semenya’s hormonal status has not been made public) whose hormonal constitution is arguably more male than female. 

Continue reading Paper used to support ban on Caster Semenya competing earns massive correction

Meta-meta-analysis meets with retraction for group that had faked peer review elsewhere

Pancreatic cancer (artist rendering)

Researchers in China have lost a 2015 meta-analysis on pancreatic cancer, one of several retractions for members of the group stemming from a variety of abuses including bogus authorship and fake peer review. 

The meta-analysis, “Correlation between serum levels of high mobility group box-1 protein and pancreatitis: a meta-analysis,” appeared in BioMed Research International, a Hindawi journal. The authors are affiliated with China Medical University in Shenyang and Shanghai Jiao Tong University.

Here’s the notice

Continue reading Meta-meta-analysis meets with retraction for group that had faked peer review elsewhere

Journal expresses a great deal of concern over deceased author’s work

A gastroenterology journal has issued an extensive expression of concern about a 2013 paper by Yoshihiro Sato, a Japanese endocrinologist who has posthumously been climbing the Retraction Watch leaderboard. (He’s now ranked number three, ahead of Diederik Stapel.)

To call the statement an “expression of concern” is like calling Charles M. Schulz a talented cartoonist, or Escoffier a pretty good cook. Indeed, the journal expresses so much concern, about, well, so much, that we’re not sure what in the paper would be left unscathed. 

Sato, formerly of Hirosaki University, currently has 77 retractions for a range of misconduct-related issues including likely data fabrication and duplication.

Continue reading Journal expresses a great deal of concern over deceased author’s work

Cancer specialists in Mexico earn third retraction following questions about their data

Cases of cancers seen at the Instituto Mexicano del Seguro Social, according to researcher Agustin Avilés

A group of cancer researchers in Mexico has lost their third paper over concerns about the integrity of their data. 

Neither the new retraction, in the journal Hematology, nor the previous two, cite misconduct as the reason for the removals. However, the statements do refer to lack of reliability of results,  “ambiguities and inconsistencies” in the findings and other serious issues. 

The first author on each paper is Agustin Avilés, whom the Hematology article listed as being with the National Medical Center in Mexico City. 

According to the retraction notice

Continue reading Cancer specialists in Mexico earn third retraction following questions about their data

Stanford calling for retractions of work by deceased star cancer researcher

The Journal of Clinical Investigation has retracted two papers from the lab of one of Stanford University’s most prominent cancer researchers over concerns about the integrity of the data. 

The articles, published in 2012 and 2014, described work on ways of priming the immune system to enhance the activity of drugs to fight cancer. 

The first author on the two articles was Holbrook “Brook” Kohrt, a superstar young faculty member who died in 2016 of complications of hemophilia. Kohrt was the subject of this 2013 profile in the New York Times, which also wrote an obituary of him. 

Continue reading Stanford calling for retractions of work by deceased star cancer researcher

Catholic medical journal pulls paper on conversion therapy over statistical problems

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The journal for a religious medical group is retracting a paper that supported the discredited practice of conversion therapy for homosexuals over concerns about the statistical analyses — or lack thereof — in the research.

The paper, “Effects of therapy on religious men who have unwanted same-sex attraction,” was published last year in The Linacre Quarterly, the official journal of the Catholic Medical Association. (According to its website: “LQR explores issues at the interface of medicine and religion, focusing on bioethics and also exploring medical topics which have an ethical dimension.)

So, what were those effects? Pretty darn good, according to the article. Per the abstract:

Continue reading Catholic medical journal pulls paper on conversion therapy over statistical problems

CrossFit demands retraction of paper claiming their participants are more likely to be injured

via U.S. Army

Saying that a paper has “fatal and disqualifying errors,” CrossFit is demanding the retraction of a recently published article that claimed those participating in CrossFit “are more likely to be injured and to seek medical treatment compared with participants in traditional weightlifting.”

The paper, “Likelihood of Injury and Medical Care Between CrossFit and Traditional Weightlifting Participants,” was published on May 7 in the Orthopaedic Journal of Sports Medicine.

In a May 17 letter to the journal’s editor and the paper’s corresponding author, CrossFit general counsel Marshall Brenner said the article

Continue reading CrossFit demands retraction of paper claiming their participants are more likely to be injured

Too much skin in the game: Derm journal calls out author for duplication

We often praise authors for doing the right thing by retracting with transparency. Here’s a journal that deserves recognition for its handling of a case of duplicate publication.

Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ADAPA), a European derm publication, has retracted a 2018 article in smack-down fashion, calling out a co-author for deceit. The paper was a case study titled “Inflamed bilateral linear atrophoderma of Moulin in an adult woman: a case report.” According to ADAPA, a reader noticed that a virtually identical article — with the same title — had appeared in a Turkish dermatology publication in late 2017.

In an lengthy editorial, Jovan Miljković, the editor-in-chief of the journal, explained what happened after a review of the two papers found them to be “virtually identical”: Continue reading Too much skin in the game: Derm journal calls out author for duplication