An Ontario court has quashed part of a misconduct finding against a prominent husband and wife team by the University Health Network in Toronto.
Last year, we reported that Sylvia Asa had stepped down from her position as Program Medical Director of the Laboratory Medicine Program at the UHN — the largest hospital diagnostic laboratory in Canada — after an investigation uncovered evidence of falsified data in two papers co-authored with her husband, Shereen Ezzat. Both of their research labs were also suspended as a result. The researchers subsequently appealed the decision.
Friday Sunday, the Toronto Star reported that the court had set aside the finding of falsification, but upheld a finding of misconduct in the form of material non-compliance. It asked UHN to review the sanctions against both researchers, and cover their legal fees of $20,000.
Here’s the conclusion from the decision:
The Decision that the Applicants had committed Research Misconduct in the form of falsification and fabrication is set aside. The Decision that the Applicants had committed Research Misconduct in the form of Material Non-Compliance is upheld. The question of the appropriate sanction is remitted to Drs. Chan and Paige for reconsideration in light of the findings of this court.
As per the agreement of the parties, the Applicants are entitled to their costs of this application, fixed in the amount of $20,000.00.
We understand the Court’s reasons for declining to overturn the third allegation, namely material noncompliance with accepted standards. Nevertheless, we note that the scientific validity of our work was never an issue at any level of the proceedings.
Having dedicated years of our lives to research, allegations of falsification and fabrication of data strike at the very core of what we hold dear, and we feel vindicated that the court has exonerated us. We are grateful that our justice system restored our integrity in this most serious matter and we look forward to continuing our work of conducting research to understand and treat human disease.
A spokeswoman for UHN explained the court’s interpretations of the investigation’s findings in two statements that she sent to us, as well as to the Star. One explains, in part:
The Court did not set aside the Investigation Committee ‘s finding that falsification and fabrication had “occurred” in the research lab of Drs. Asa/Ezzat. However, the Court was of the view that this finding could conceivably be misinterpreted as a conclusion that Drs. Asa and Ezzat had themselves personally engaged in conduct that amounted to falsification and fabrication, and that this interpretation might have influenced the sanction that was imposed.
The second statement explains, in part:
It must be remembered that the Investigation Committee found numerous instances of fabrication and falsification over a period of more than 10 years. The Investigation Committee also expressly noted, as the Court pointed out in its decision, that the Investigation Committee could not determine exactly who was directly responsible for fabricating or falsifying the images in question.
Asa and Ezzat have co-authored nearly 100 papers together, three of which have been retracted. The retraction notes confirmed the existence of the UHN investigation, and that the committee found that two “articles in question contain falsified data,” and another contained duplicated portions of gels.
One of Asa and Ezzat’s papers has been flagged with an expression of concern, and more than a dozen more have been questioned on PubPeer.
The UHN statement explains what will happen next:
We expect that reconsideration of the sanction will be completed in the next few weeks and that the matter will then be concluded, subject to the completion of the investigation of the additional papers, which is still ongoing.
Given that we have a further step to take in this process, as directed by the Court, we have no further comment at this time.
The court decision notes the impact of the researchers’ work on the health of Ontario residents:
In this matter, the Decision is one concerning the Applicants’ ability to continue performing cancer research, research that affects the medical protocols used in the treatment of cancer for the people of Ontario. For example, as noted in the Applicants’ materials, their work has led to the creation of “the largest and only Pathology Department that included all sub-specialized areas of pathology, relied on by 22 other hospitals across Ontario.”
Hat tip: Andrew Paterson
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