Retraction Watch

Palmitoleic acid paper pulled for data concerns

A journal has retracted the 2014 report of a clinical trial of a supplement touted as a way to reduce the risk of cardiovascular disease after beginning to suspect that the data were not reliable.

The study, “Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: A double-blinded, randomized, placebo controlled study,” was published in the Journal of Clinical Lipidology, an Elsevier title. It has been cited 42 times, according to Clarivate Analytics’ Web of Science.

The authors were Adam Bernstein and Michael Roizen, of the Wellness Institute at Cleveland Clinic, and Luis Martinez, who at the time was the president of the Xyrion Medical Institute, in Puerto Rico.

Roizen, an anesthesiologist and the founding chair of the Wellness Institute, is the co-creator of the RealAge test, which he developed along with Mehmet Oz.

Roizen and Oz have been hawking palmitoleic acid — an omega-7 fatty acid that is the subject of the now-retracted study — for some time. In this 2019 article, for example, the pair wrote:

Pharma company demands retraction, damages in lawsuit against journal

A drug company that manufactures a painkiller used for surgery patients has sued an anesthesiology journal along with its editor and publisher and the authors of articles that it says denigrated its product unfairly.

In a complaint filed yesterday in U.S. District Court in New Jersey, Pacira Biosciences claims that “In the February 2021 issue of Anesthesiology, the ASA, reflecting a bias against EXPAREL amongst the editorial staff at Anesthesiology, published three articles, and other related content, that seriously disparage Pacira’s product EXPAREL,” an FDA-approved drug which they say is “a non-opioid pain medication proven to prolong post-surgery pain relief.”

In seeking retractions, compensatory and punitive damages exceeding $75,000 — the threshold for U.S. federal court — and lawyers’ fees, the company’s attorneys at Latham & Watkins write:

You want to do what? Paper on anal swabs for COVID-19 retracted for ethical issues

An article claiming that anal swabs can be used to detect SARS-CoV-2 in patients cured of Covid-19 has been retracted after the journal found that the authors failed to get permission from the patients to conduct the study.

To be clear: We’re not sure if the researchers — from Weihai Municipal Hospital, in Shandong, China — didn’t tell the patients they were taking anal swabs (which seems, well, unlikely) or that they didn’t tell them they would be using the results of the swabs in a study (the more reasonable interpretation). But the notice is vague on that point.

You may recall that in January the Chinese government in January launched a program to implement widespread anal swabbing to look for SARS-CoV-2 — a plan that, as the Washington Post reported, did not meet with cheers from the local population.

The article, “Anal swab as the potentially optimal specimen for SARS-CoV-2 detection to evaluate the hospital discharge of COVID-19 patients,” appeared in July in Future Microbiology. According to the abstract:

University in Japan revokes doctorate for plagiarism of text, image

A researcher in Japan has been stripped of his doctorate after a university investigation found that his thesis contained seven lines of plagiarized text and an image pulled from the internet without attribution.

Takuma Hara received his PhD in medical sciences from Tsukuba University in March 2019, writing a thesis about a genetic mutation’s role in certain brain tumors. Allegations of misconduct against Hara first emerged on April 6, 2020, according to a report released by the school.

The university launched an investigation, interviewed Hara and found that the thesis contained two plagiarized snippets: a microscopy image was pulled from the web without attribution and, on page 6, Hara took seven lines of text from a 2016 paper, titled “Clinicopathological features of craniopharyngioma and the endoscopic endonasal surgery,” published in a Japanese journal called Progress in Neuro-Oncology. The university revoked Hara’s degree last month.

One in six of the papers you cite in a review has been retracted. What do you do?

The author of a 2014 review article about the role of vitamin D in Parkinson’s disease has alerted readers to the fact that roughly one-sixth of her references have since been retracted. But she and the journal are not retracting the review itself.

The paper, “A review of vitamin D and Parkinson’s disease,” appeared in Elsevier’s Maturitas, which is the official journal of the European Menopause and Andropause Society. The author is Amie Hiller, a neurologist at Oregon Health & Science University in Portland, and the work has been cited 26 times, according to Clarivate Analytics’ Web of Science.

According to Hiller, she recently became aware that 10 of the 63 references in her article were to papers by Yoshihiro Sato, a bone researcher in Japan whose 103 retractions put him in the third position on the Retraction Watch leaderboard. Sato’s misdeeds run from lack of IRB approval to fabrication of data, in articles dating back to the mid-1990s.

Hiller’s letter on the subject, recently published in Maturitas but not linked from the original review, states that:

The rector who resigned after plagiarizing a student’s PhD thesis

Lots of good stories are hiding behind retraction notices, and with the flood of retractions — 2,200 just in 2020 — we can’t always keep up. Here’s a story about one 2020 retraction that turns out to involve a rector in Poland who resigned after plagiarizing a student’s PhD thesis.

In 2014, Błażej Kochański defended his PhD thesis at Gdańsk University of Technology, where he is now an assistant professor. To pass the exam, two external reviewers — one of whom was Jerzy Gwizdała, an economist at the University of Gdańsk — evaluated his work.

The following year, Gwizdała published a study titled, “Wpływ systemowego ryzyka płynności na stabilność gospodarki polskiej,” or “The Impact of Systemic Liquidity Risk on Stability of the Polish Economy,” in Problemy Zarządzania (Management Issues). Entire sections of that paper, according to a note Kochański sent us through our database Google form, were “copy-and-paste” plagiarized from his PhD thesis.

Gwizdała also translated sections of Kochański’s PhD thesis to English in 2018, sent it to the University of Gdańsk Publishing House, and had it published as a book chapter.

Weekend reads: Faked data in psychology; publishing in predatory journals = misconduct?; how scientists take criticism

Before we present this week’s Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance.

The week at Retraction Watch featured:

Seven barred from research after plagiarism, duplications in eleven papers
An author asked for multiple corrections to a paper. PLOS ONE decided to retract it.
Researcher charged with abusing his wife has third paper retracted
Apparent HeLa cell line mixup earns a paper an expression of concern
Anesthesiologist loses 50 more papers in 12 months

Our list of retracted or withdrawn COVID-19 papers is up to 117.

Here’s what was happening elsewhere (some of these items may be paywalled, metered access, or require free registration to read):

Anesthesiologist loses 50 more papers in 12 months

A decade has passed since the breaking of the scandal involving Joachim Boldt, a world-renowned critical care specialist who has held steady as the number two author on the Retraction Watch leaderboard. But the case continues to produce developments that have dramatically increased Boldt’s retraction tally.

Journals have retracted at least 53 papers by Boldt since May 2020, bringing his total number to 153, by our count. That includes 24 articles removed so far in 2021. In September 2020, the British Journal of Anaesthesia announced that it was retracting all but one of the more than two dozen Boldt papers that it had published — leaving the last one standing because it didn’t have solid evidence that it contained fabricated data.

The impetus for the purge was a 2018 report from Justus Liebig University (JLU) Medical School, where Boldt worked between 1982 and 1996. The university concluded that, among other things, Boldt appears to have fabricated data from several theses of students he helped supervise, publishing the doctored results without their knowledge.

Apparent HeLa cell line mixup earns a paper an expression of concern

A journal has issued an expression of concern for a 2011 paper after recognizing that the researchers may have been using contaminated cell lines.

The article, “Downregulation of NIN/RPN12 binding protein inhibit [sic] the growth of human hepatocellular carcinoma cells,” appeared in Molecular Biology Reports, a Springer Nature title. In it, the authors, from China Medical University Shengjing Hospital, sought to find:

whether the suppression of Nob1 by short hairpin RNA (shRNA) inhibits the growth of human hepatocellular carcinoma (HCC) cells. Recombinant lentiviral shRNA expression vector carrying Nob1 was constructed and then infected into human HCC cell line SMMC-7721

Perhaps they did, and the paper has been cited 21 times, according to Clarivate Analytics’ Web of Science. However, experimental lines of SMMC-7721 cells are among the many cell lines known to have been contaminated by HeLa cells, named for Henrietta Lacks — highly proliferative cervical cancer cells that have overrun labs worldwide. So perhaps they didn’t.

As the EoC states:

Researcher charged with abusing his wife has third paper retracted

A researcher in Canada whose once-brilliant career in kinesiology went from plaudits from his peers to criminal charges of horrific abuse of his wife has notched his third retraction.

As we reported in 2018, Abdeel Safdar, formerly of McMaster University and Harvard, where he was a postdoc, was the subject of an institutional investigation over concerns about the integrity of the data in a pair of his published studies. At the time, journals had flagged only two of his articles, both written with a frequent co-author, Mark Tarnopolsky, of McMaster. Tarnopolsky is considered a leading figure in kinesiology, and together he and Safdar had written some 30 papers.

The newest retraction involves a 2016 article in Skeletal Muscle titled “Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.” Safdar was first author and Tarnopolsky the senior and corresponding author.

According to the retraction notice:

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