clinical study retractions – Page 3

Research integrity during the COVID-19 pandemic: A book excerpt

We are pleased to present an excerpt from Thinking About Science: Good Science, Bad Science, and How to Make It Better by Ferric C. Fang and Arturo Casadevall, published by ASM Press/Wiley, October 2023.

Amidst the COVID-19 calamity, one can argue that science is one of the few aspects of the human response that has worked relatively well. However, despite the many advances in preventing and treating COVID-19, there have also been missteps as the world has scrambled to respond to a deadly new pathogen. It has been humbling for the U.S. to lead large high-income countries in per capita deaths from COVID-19 even with its wealth and scientific expertise. We are all too aware of the needless illnesses and deaths that have resulted from misguided political leadership, inadequate preparation, delayed responses, fragile supply chains, health disparities, and vaccine hesitancy. But we will not dwell on these issues here. Rather, we would like to review the COVID-19 pandemic through the prism of the 3R’s of research integrity: rigor, reproducibility, and responsibility. These form the fundamental pillars of the foundation of science. It is appropriate that we devote more attention to the foibles than to the successes so that we can learn from the mistakes and missed opportunities. What could have been done better? What needs to improve?

Publisher looking into COVID vaccine paper with ‘serious flaws’

A controversial paper on the safety and immunogenicity of an Iran-made COVID-19 vaccine is being investigated by the U.S.-based publisher Wiley, Retraction Watch has learned.

Iran reportedly has already administered 3 million doses of the vaccine, dubbed Noora, which the country licensed for emergency use last year.

The paper describes the vaccine’s first test in humans, marking the only time results from the clinical development of the homegrown shot have been reported in international journals.

“Safety and immunogenicity of a recombinant receptor-binding domain-based protein subunit vaccine (Noora vaccine™) against COVID-19 in adults: A randomized, double-blind, placebo-controlled, Phase 1 trial” was published in 2022 in the Journal of Medical Virology, an achievement highlighted in Iranian news media. One report said the study showed a dose of 80 micrograms of the vaccine was “safe” and provided “adequate immunity in adults.”

To guard against fraud, medical research should be a profession: A book excerpt

We are pleased to present an excerpt from Trust in Medical Research, a freely available new book by Warwick P. Anderson, emeritus professor of physiology and biomedical sciences at Monash University in Victoria, Australia.

It has always been difficult for me to admit that we have a genuine and substantial problem of fraud and rubbish science in medical research. I suspect this is true for most scientists. We want to think of science as being free from half-truths and fake news. We hope that the high moral purpose of medical research will guard against wrongdoing, that it will weigh on our minds so heavily that we all take care to work and publish honestly and competently.

We know that scientists sometimes make unintentional mistakes due to ignorance, but we also know in our hearts that some people are so ambitious that they push the envelope, stretch the truth and take shortcuts. We know, too, that a few others go further and get carried away by the prospects of scientific and financial rewards and so cheat, commit fraud and lie in publications. This is what some humans do in all walks of life.

We know all this, but it is fair to say that we generally do not want to face up to it. Jennifer Byrne at the University of Sydney put it well when she wrote that we tend to overlook the research fraud issue “because the scientific community has been unwilling to have frank and open discussions about it”:

Exclusive: Probe suggests new retraction awaiting embattled Korean heart doctor

A prominent physician-scientist in South Korea may soon be facing his fourth retraction. Last month, Hui-Nam Pak of Yonsei University was found guilty of duplicate publication, a form of academic misconduct, according to a report from the school’s committee on research integrity Retraction Watch has obtained.

Pak, a cardiologist, has had dozens of papers flagged on PubPeer. As we reported in February, journals pulled two of his papers the previous month after a whistleblower pointed out problems with the articles. One was retracted for “a number of issues related to scientific misconduct,” while the other was a duplicate publication. A third paper by Pak was retracted years earlier after mistakenly being published twice by the same journal.

Our February story triggered a flood of comments, many of them malicious. Some likened whistleblowing to “academic vandalism.” Others asserted that “whistleblowers deserve strong legal penalties” and that “immoral whistleblowers” seemed bent on ruining Pak’s “outstanding career.” Many comments were rejected for not adhering to our commenting policies, in particular making unsubstantiated claims.

The September 12 report from Yonsei University (in Korean) explains that an “informant” reported two of Pak’s papers to the school’s Research Ethics Integrity Committee on March 7.

Paper that helped form basis of pricy research tool retracted

Nearly four years after a critic pointed out flaws in a paper about a controversial research tool involved in nearly 20 retractions, the owner of that instrument has lost the article after he failed to overcome the editors’ concerns about the work.

The owner is Donald Morisky, of the University of California, Los Angeles, whose name should be well-familiar to readers of Retraction Watch.

Morisky developed the Morisky Medication Adherence Scale (MMAS), then began charging researchers up to six-figure sums to license the use of the tool in their own studies. Those who didn’t sign agreements in advance were ordered to retract their papers that used the MMAS, pay Morisky’s company retroactively, or risk legal action. (We wrote about all this in Science back in 2017. We also wrote about how Morisky and his former business partner, Steve Trubow, have been engaged in litigation over ownership of a spin-off “widget” Trubow says belongs to him. That case is ongoing.)

Outcry over ‘terminal anorexia’ response letter prompts retraction

The authors of a response to an article critiquing the use of the term “terminal anorexia” retracted their letter last month after receiving major backlash from researchers, healthcare providers, and people with eating disorders.

“Regardless of inequities in care, terminal anorexia nervosa exists: a response to Sharpe et. al,” which defended the use of the term, was published May 20 in the Journal of Eating Disorders.

The letter was a response to “Inaccessibility of care and inequitable conceptions of suffering: a collective response to the construction of “terminal” anorexia nervosa,” an article published earlier in the month in the same journal by researchers with lived experiences of eating disorders. The article outlined methodological problems with the criteria for diagnosis of a “terminal eating disorder” put forward in “Terminal anorexia nervosa: three cases and proposed clinical characteristics,” a previous paper by two of the authors of the response letter.

The response was retracted on July 17. Its retraction note reads:

University cuts anesthesiology researcher’s funding amid four retractions

An anesthesiologist who had his funding revoked for fabricating data has earned a fourth retraction for publishing the same data in two Springer Nature journals.

Wen-fei Tan, an anesthesiologist at The First Hospital of China Medical University in Shenyang, is the first author of the recently retracted paper “Changes in the first postoperative night bispectral index of patients after thyroidectomy with different types of primary anesthetic management: a randomized controlled trial,” published in the Journal of Clinical Monitoring and Computing (JCMC), a Springer Nature journal, in 2017. It has been cited four times, according to Clarivate’s Web of Science.

The retraction notice states:

Highly cited Lancet long COVID study retracted and republished

One of the first studies of long COVID has been retracted and replaced seven months after editors marked it with an expression of concern citing “data errors.”

The original paper, “6-month consequences of COVID-19 in patients discharged from hospital: a cohort study,” was published in The Lancet in January 2021. It was “the first large cohort study with 6-months’ follow-up” of people hospitalized with COVID-19, according to an editorial published simultaneously, and has been cited more than 2,000 times, according to Clarivate’s Web of Science. The World Health Organization, for example, cited it in several documents.

Last November, the article received an expression of concern stating that a researcher had contacted the journal about inconsistencies between that study and a paper published in August 2021, also in The Lancet, describing the same cohort of patients after one year of follow up.

‘Compromised’ survey data leads to article retraction and university investigation

An article based on results from an online survey has been retracted for data issues, and an Australian university is investigating what happened.

The article, “International nursing students’ perceptions and experiences of transition to the nursing workforce – A cross-sectional survey,” became available online on Jan. 29, 2022.

Published in the journal Nurse Education in Practice, the study reported 110 responses to an online survey of nursing students who came to Australia from other countries and planned to remain there to work.

The retraction notice, posted this month, stated:

Australian study supporting mask mandates earns expression of concern

A journal has issued an expression of concern for an Australian study that supported mask mandates after researchers raised several potential problems with the design and methodology of the study.

The article, “The introduction of a mandatory mask policy was associated with significantly reduced COVID-19 cases in a major metropolitan city,” was published in the journal PLOS ONE in July 2021. It has been cited 12 times, according to Clarivate’s Web of Science.

In comments to Retraction Watch, the authors of the paper stood by their work, but a key critic said he still thought the work should have been retracted.

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