basic life sciences retractions – Page 2

Brain tumor researchers retract paper from Science journal

A detail from Fig. 6 of the now-retracted paper

A brain tumor researcher at the University of California, San Francisco, has retracted a paper from Science Translational Medicine, and is a co-author on an article that another journal is examining.

The problems in both papers, and several others with shared authors, came to light via comments on PubPeer by Elisabeth Bik and a pseudonymous commenter.

The Science Translational Medicine paper, “A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells,” was published last May by a group led by Russell O. Pieper, director of basic science in the UCSF Brain Tumor Center and vice-chairman of the UCSF department of neurological surgery. The paper has been cited six times, according to Clarivate’s Web of Science.

Exclusive: Cancer researcher sues med school for retaliation after research misconduct finding

A breast cancer researcher at SUNY Downstate in Brooklyn has sued the university for sex discrimination and retaliation after an institutional investigation found she committed research misconduct.

Stacy Blain, an associate professor in the departments of pediatrics and cell biology at Downstate, has alleged that the university violated the Equal Pay Act by paying her less than her male colleagues; discriminated against her based on her sex since she joined the faculty in 2002, including by conducting multiple investigations into her lab’s work; and used the latest investigation and its finding that she committed research misconduct to retaliate against her for accusing the university of sex discrimination.

From the lawsuit:

Papers on Alzheimer’s slapped with expressions of concern

A Science journal has issued expressions of concern for two papers on Alzheimer’s disease over concerns about the integrity of the data.

One involves a 2016 article by a star-studded group of neuroscience researchers over allegations of manipulated data in one of the figures. That paper, “Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease,” appeared in Science Signaling and came from a team led by Rudolph Tanzi and Roberto Malinow, of Harvard and UC San Diego, respectively.

Here’s the notice for the paper, which has been cited 64 times, according to Clarivate’s Web of Science:

Exclusive: University of Glasgow seeking retraction of multiple papers after findings of image manipulation

The University of Glasgow is requesting the retraction of multiple papers by a pharmacology researcher who held various positions there for more than a quarter century.

The story begins in December 2016, when biostatistician Steven McKinney posted on PubPeer about a paper by the researcher, Miles Houslay, in the Journal of Biological Chemistry. That paper was eventually retracted in August 2020, but not before McKinney posted a comment on Retraction Watch that caught the eye of the pseudonymous Clare Francis.

Francis pointed us to comments about a total of eight of Houslay’s papers at that time. And in August 2020, when the JBC retraction appeared, Francis forwarded those to the King’s College, London, where Houslay is listed as having a faculty position, and the University of Glasgow, which he left in 2011.

Science journal retracts paper after university investigation finds ‘carelessness and lack of attention to detail’

Science Signaling has retracted a 2017 paper marred by nearly a dozen instances of problematic figures which an institutional investigation concluded were the result of shoddy work on the federally-funded study — but not deliberate misconduct.

The article, “The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor,” came from a group led by Toni Brand, then of the Department of Human Oncology at the University of Wisconsin School of Medicine and Public Health, in Madison, where most of the co-authors were based as well.

The paper has been cited 28 times, according to Clarivate Analytics’ Web of Science. The researchers presented an abstract of the study at the 2017 annual meeting of the American Association for Cancer Research, although that does not appear to have been cited.

According to the retraction notice:

Researcher committed misconduct while at NIH, say institutes — but is allowed to publish a revised version of a paper

An investigation by the National Institutes of Health has led to the retraction of a 2016 paper in PLOS Biology for manipulation of the data in the article. But the journal has republished a revised version of the paper — minus the bad data — on which the researcher found to have committed the misconduct remains the first author.

The original article, “Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis,” came from the laboratory of Carole Parent, who was a cancer researcher at the NIH at the time it was published and is now at the University of Michigan, in Ann Arbor. It has been cited 93 times, according to Clarivate Analytics’ Web of Science.

According to the notice:

‘Regrettably it took too long to investigate and retract this paper.’

A journal has expressed regret over its sluggish response to image hijinx in a 2017 paper on the antimalarial properties of a kind of pea plant.

The article, “Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA),” was written by P. V. V. Satish and K. Sunita, of the Department of Zoology and Aquaculture at Acharya Nagarjuna University.

The paper drew scrutiny on PubPeer four years ago, where commenters noted issues with the figures.

Time passed, and the paper was cited six times, according to Clarivate Analytics’ Web of Science. Now, according to the retraction notice:

Seven barred from research after plagiarism, duplications in eleven papers

A retired Nepali professor and six others have been barred from research after plagiarism and duplicated images were found in 11 of their papers.

Parashuram Mishra, a retired crystallographer at Tribhuvan University, in Nepal, is the lead author on all the studies. Most of the papers contain image duplications; the same figures were reused across multiple studies. But two figures that Mishra published, according to the university’s findings, were plagiarized from a 2010 study by a British team, and a 2020 study by researchers at the University of Monastir, in Tunisia.

Last December, Armel Le Bail, crystallographer at the Université du Maine in Les Mans, France, began flagging Mishra’s studies on PubPeer and his personal website. He reported his findings to the vice-chancellor of Tribhuvan University, Dharma Kant Baskota, on January 4th.

“Falsifying elements” prompt retraction of three more papers by former “Peorian of the Year”

Jasti Rao, a former star scientist at the University of Illinois College of Medicine at Peoria whose career flamed out over concerns about misconduct, gambling and allegations that he had mistreated employees, is now up to 16 retractions.

The International Journal of Oncology, a Spandidos title, has retracted three of Rao’s papers dating back to 2011, citing the presence of “falsifying elements” in the images.

Here’s the notice for the 2011 paper “Oncogenic role of p53 is suppressed by si‑RNA bicistronic construct of uPA, uPAR and cathepsin‑B in meningiomas both in vitro and in vivo”:

Bad blood at a lab leads to retraction after postdoc publishes study without supervisor’s permission

A former postdoc at Stony Brook University who was moonlighting in a different lab has lost a study after a university investigation found issues with the work, including “overlap” with prior grants and an earlier study that her supervisor had published, as well as misreported data.

The supervisor — neuroscientist Joshua Plotkin, who was the complainant in the investigation — said that the study was published without his permission, according to an email seen by Retraction Watch. The former postdoc, Catarina Cunha, has denied wrongdoing and called the investigation a “witch hunt,” claiming that the university ignored her exculpatory evidence and that the paper’s findings are valid and original.

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