Marc Tessier-Lavigne, whose resignation as president of Stanford University becomes effective today, is retracting two papers from Science following an institutional investigation that found data manipulation in multiple figures.
Both articles, “Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex,” and “Binding of DCC by Netrin-1 to Mediate Axon Guidance Independent of Adenosine A2B Receptor Activation,” were published in 2001, when Tessier-Lavigne, the corresponding author, was at the University of California, San Francisco. They have been cited well over 600 times in total, according to Clarivate’s Web of Science.
Anonymous users on PubPeer posted concerns about potentially manipulated images in the papers as early as 2015. Reporting by The Stanford Daily in November 2022 spurred the university to launch an investigation into several of Tessier-Lavigne’s papers, how he responded when others identified issues in his articles, and the culture of his lab.
The university published the final report last month, finding that four of the five papers it reviewed on which Tessier-Lavigne was a principal author contained “apparent manipulation of research data by others.” Tessier-Lavigne, the investigation committee concluded:
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