Cancer lab at Harvard subject of inquiry

James Mier

Harvard has investigated work from the lab of a cancer researcher at Beth Israel Deaconess Medical Center that has been under scrutiny on PubPeer for more than five years.

Questions about the output of the lab, run by James W. Mier, began appearing on PubPeer in 2014, with comments about images that looked manipulated. The pseudonymous whistleblower Clare Francis sent Gretchen Brodnicki, Harvard Medical School’s dean for faculty and research integrity, an email about those comments on Sept. 27, 2014, and on July 24 of this year, Brodnicki asked Francis to resend that email.

Also that month, the journal Clinical Cancer Research issued an expression of concern for a 2006 paper by Mier and colleagues, which stated:

Continue reading Cancer lab at Harvard subject of inquiry

Drip, drip: Former Harvard stem cell researcher up to 18 retractions

Piero Anversa

Piero Anversa, a former star researcher at Harvard Medical School who left the institution under a cloud, is up to 18 retractions. But that’s barely half of the 31 papers by Anversa’s group that Harvard has requested journals pull over concerns about the integrity of the findings. 

The two articles, published in the Proceedings of the National Academy of Sciences, appeared in 2008 and 2009. Anversa and a frequent co-author, Annarosa Leri, are among the authors on each. 

Anversa ran a richly-funded lab at Brigham and Women’s Hospital studying cardiac stem cells. But in 2014, critics began publicly questioning the output from the lab — questions that led to the departure of Anversa and Leri and a $10 million payout from the Brigham and Partners Healthcare to settle allegations of fraud involving the work. Anversa and Leri also sued Harvard — unsuccessfully — for alerting journals to the investigation and allegedly costing them job offers.

The retraction notice for the 2008 paper, “Notch1 regulates the fate of cardiac progenitor cells,” reads

Continue reading Drip, drip: Former Harvard stem cell researcher up to 18 retractions

Columbia historian stepping down after plagiarism finding

Charles Armstrong

A tenured professor of history at Columbia University will be stepping down at the end of next year after an investigating committee at the school found “incontrovertible evidence of research misconduct” in his controversial 2013 book.  

Charles King Armstrong, the Korea Foundation Professor of Korean Studies in the Social Sciences, was found to have “cited nonexistent or irrelevant sources in at least 61 instances” in “Tyranny of the Weak: North Korea and the World, 1950-1992,” according to the Columbia Spectator, which first reported on the resignation last week. 

In a September 10 letter, Maya Tolstoy, dean of the Faculty of Arts and Sciences, announced the news to the institution: 

Continue reading Columbia historian stepping down after plagiarism finding

“Highly unusual and unfortunate error” delays retraction two years in high-profile Duke case

As we’ve noted before, “the wheels of scientific publishing turn slowly … but they do (sometimes) turn.” 

More than six years after the first retraction for Erin Potts-Kant, who was part of a group at Duke whose work would unravel amid misconduct allegations and lead to a $112.5 million settlement earlier this year with the U.S. government — and two years after a journal says it first became aware of the issues — a retraction by the group has appeared in Pediatric Research, a Springer Nature title.

Here’s the retraction notice for “Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats”:

Continue reading “Highly unusual and unfortunate error” delays retraction two years in high-profile Duke case

Statisticians clamor for retraction of paper by Harvard researchers they say uses a “nonsense statistic”

via ImageCreator

“Uh, hypothetical situation: you see a paper published that is based on a premise which is clearly flawed, proven by existing literature.” So began an exasperated Twitter thread by Andrew Althouse, a statistician at University of Pittsburgh, in which he debated whether a study using what he calls a “nonsense statistic” should be addressed by letters to the editor or swiftly retracted.

The thread was the latest development in an ongoing disagreement over research in surgery. In one corner, a group of Harvard researchers claim they’re improving how surgeons interpret underpowered or negative studies. In the other corner, statisticians suggest the authors are making things worse by repeatedly misusing a statistical technique called post-hoc power. The authors are giving weak surgical studies an unwarranted pass, according to critics.

Continue reading Statisticians clamor for retraction of paper by Harvard researchers they say uses a “nonsense statistic”

More troubles at Duke: NIH suspended grants because of concerns over patient safety

Duke University

Last year, amid concerns for patient safety, the U.S. National Institutes of Health (NIH) suspended seven grants to Duke University following “allegations of research misconduct…and…potential issues concerning clinical research irregularities,” we now know thanks to a letter from NIH to Duke.

Continue reading More troubles at Duke: NIH suspended grants because of concerns over patient safety

Harvard cancer lab subject to federal misconduct probe

Sam W. Lee, a Harvard researcher — or perhaps former Harvard researcher — who has lost three papers to retraction, including one from Nature, now has an expression of concern for another article, this one in Molecular and Cellular Biology.

The notice for that paper, 2000’s “Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression,” reads: Continue reading Harvard cancer lab subject to federal misconduct probe

Joseph Thomas just earned $33.8 million in a $112.5 million settlement with Duke. Here’s his story.

Joseph Thomas

Tomorrow is Joe Thomas’s 35th birthday. And earlier this week, he received quite a birthday present, even if it wasn’t intended that way: Thomas earned a $33.75 million payout from a lawsuit he filed against Duke University six years ago.

As Retraction Watch readers may recall, Thomas was the whistleblower in a case alleging scientific misconduct that Duke settled yesterday for $112.5 million. Our Ivan Oransky has an exclusive profile of him — including how he “celebrated” the settlement — at Medscape. Continue reading Joseph Thomas just earned $33.8 million in a $112.5 million settlement with Duke. Here’s his story.

Duke settles case alleging data doctoring for $112.5 million

Retraction Watch readers may recall the name Erin Potts-Kant. We’ve been reporting on retractions by Potts-Kant, a former lab tech at Duke, since 2013. (The count is now 17.) Along the way, we learned that she had been convicted of embezzlement, but that there was a bigger story: There was a False Claims Act case against Duke, Potts-Kant, and Michael Foster, in whose lab she worked, alleging that the university had known that faked data had been included in grant applications.

The case has now settled, for what Duke acknowledges is a “substantial” sum of $112.5 million. That means the whistleblower, another former lab tech, will earn more than $30 million. For details, head over to Ivan’s story on Medscape. Continue reading Duke settles case alleging data doctoring for $112.5 million

A university thought its misconduct investigation was complete. Then a PubPeer comment appeared.

When Venkata Sudheer Kumar Ramadugu, then a postdoc at the University of Michigan, admitted to the university on June 28 of last year that he had committed research misconduct in a paper that appeared in Chemical Communications in 2017, he also “attested that he did not manipulate any data in his other four co-authored publications published while at the University of Michigan.”

And so, a few days later, Michael J. Imperiale, the university’s research integrity officer, wrote a letter to the U.S. Office of Research Integrity (ORI) informing them of the findings. On August 2, Ramadagu was terminated from Michigan. And on August 3, Ayyalusamy Ramamoorthy, the head of the lab where Ramadagu had worked, wrote a letter to Chemical Communications requesting retraction of the paper.

While the retraction would not appear until the end of November, and ORI sanctions not announced until the end of December, Michigan’s responsibilities seemed to have been discharged as of early August. But documents obtained by Retraction Watch through a public records request detail how that was not the end of the story. Continue reading A university thought its misconduct investigation was complete. Then a PubPeer comment appeared.