canada – Retraction Watch

Lancet flags long-scrutinized report of infant poisoned by opioids in breast milk

The Hospital for Sick Children in Toronto

The Lancet has put an expression of concern on a 2006 case report of a baby’s death purportedly from morphine poisoning through breast milk. The decision comes just days after the New Yorker published a year-long investigation into the death and the controversies that have surrounded it.

The case report described the 2005 death of a baby boy whose mother had been prescribed Tylenol 3, which contains codeine. Gideon Koren, founder of the now-defunct Motherisk Drug Testing Laboratory at the University of Toronto’s Hospital for Sick Children, used the case for years to claim codeine – which gets metabolized to morphine in the body – can pose a lethal risk to breastfeeding infants.

“It feels like an element of vindication,” David Juurlink, professor of medicine and pediatrics at the University of Toronto, told Retraction Watch of the expression of concern. Juurlink, a pharmacologist and toxicologist who has been pursuing this case for over a decade, requested The Lancet retract the article in 2020, when he and a colleague published a review article calling into question key elements of the case report. The paper, he said, “really does serve as the foundation of an entire branch of pediatric pharmacology that shouldn’t exist.”

Panel upholds results of contested U Toronto mammography study

The University of Toronto has quietly published the results of an inquiry into the Canadian National Breast Screening Study that began in 2022 and, it seems, concluded in March 2024.

The panel, tasked with evaluating new allegations about the trial’s randomization, found the evidence it reviewed did not affect the results of the trials, which called into question the value of mammography in women ages 40-59.

Imaging scientist Martin Yaffe of the University of Toronto has long been a critic of the CNBSS, a pair of randomized clinical trials of mammography conducted in the 1980s. In April, we published a guest post in which Yaffe detailed the history of the trial and his critiques of it, as well as new evidence that clinical staff may have unwittingly influenced randomization. He reported this to the Canadian Cancer Society in 2021, and to the university.

Journals investigating dozens of papers by leading Canadian urologists

A high-profile Canadian urologist received an editorial expression of concern for one of his papers this month, after anonymous comments on PubPeer flagged suspected data duplication in dozens of his articles.

By our count, sleuths have flagged 30 papers co-authored by Martin Gleave, a professor at the University of British Columbia in Canada and co-founder of the Vancouver Prostate Centre. According to the posts on PubPeer, images in these studies appear “much more similar than expected” based on analyses using the similarity detection software ImageTwin. The issues include similarities within individual papers and across multiple publications, with some comments suggesting the alleged reuse of tumor specimens.

Gleave, an appointee to the Order of Canada for his work developing treatments for prostate cancer, has received more than $120 million (approximately $84 million USD) in funding throughout his career, according to his profile on the Vancouver Prostate Centre website. He is also a co-founder of OncoGenex Pharmaceuticals, with several of the findings from the flagged papers connected to the company and related patents.

New engineering dean has two retractions for authorship manipulation

A newly appointed dean at the University of Guelph in Canada has had two papers retracted for “evidence of authorship manipulation.”

Another article by the researcher, Moncef Nehdi, formerly of McMaster University in Hamilton, Ontario, seems to match a paper that had its authorship advertised for sale, according to a post on PubPeer.

Nehdi told Retraction Watch he stands by his group’s work in the two retracted papers, but agreed with the retractions because he thought the investigations “raised some valid concerns.”

Nehdi began a five-year term as dean of the University of Guelph’s College of Engineering and Physical Sciences on September 1, according to an announcement this spring. The announcement stated:

Spider researcher Jonathan Pruitt faked data in multiple papers, university finds

An investigation at McMaster University found that Jonathan Pruitt, a behavioral ecologist by training who has had 15 papers retracted in the last three years, “engaged in fabrication and falsification” including duplicating data, according to summarized findings sent to coauthors.

Kate Laskowski, an assistant professor at the University of California, Davis, shared on Twitter the summary McMaster had sent her about three papers she had coauthored with Pruitt.

Should residents and fellows be encouraged to publish systematic reviews and meta-analyses?

The ‘publish or perish’ culture is no longer reserved for academic faculty and post-doctoral fellows. The paradigm has spilled over (or bled into) medical training, aided by the digital revolution. The widespread availability of online library catalogs and referencing software has enabled the mass production of systematic reviews and meta-analyses.

In short, medical research no longer requires original ideas, just access to the internet, which is perhaps why, as one 2018 editorial put it, there is “Replication, Duplication, and Waste in a Quarter Million Systematic Reviews and Meta-Analyses.”

With all of that in mind, the orthopaedic surgery residents at McMaster University in Hamilton, Ontario, Canada, gathered virtually for their annual research day to debate whether they supported or rejected the status quo that residents be encouraged to publish systematic reviews and meta-analyses. At the start of the debate, following an opening Visiting Professor Presentation on trends in retractions by Retraction Watch co-founder Ivan Oransky, 58% of the residents opposed the status quo, while 42% supported it.

Medical journal retracts letter calling hijab ‘an instrument of oppression’

A major Canadian medical journal has retracted a letter to the editor by a prominent surgeon in Quebec who expressed reservations about a photo the journal had published of two young girls, one of whom was wearing a hijab.

The photo in question (above) ran on the cover of the November 8, 2021 issue of the Canadian Medical Association Journal.The image prompted a letter from Sherif Emil, an endowed chair of surgery at Montreal Children’s Hospital of McGill University. Published December 20, the letter voiced concern that the photograph used “an instrument of oppression [the headcovering] as a symbol of diversity and inclusion.” (That’s in the title of the letter, which the journal now acknowledges writing, not Emil.)

As the CBC reported, Emil wrote that:

Behavioral ecologist Jonathan Pruitt’s PhD dissertation withdrawn

Jonathan Pruitt, a behavioral ecologist and Canada 150 Research Chair who has had a dozen papers retracted following allegations of data fraud, now appears to have had his doctoral dissertation withdrawn.

The news, which was first noted by Nick DiRienzo, who co-authored papers with Pruitt but has been one of the scientists trying to cleanse the scientific record of Pruitt’s problematic work, suggests that Priutt now lacks a PhD, generally considered a requirement for professorships.

Researcher charged with abusing his wife has third paper retracted

A researcher in Canada whose once-brilliant career in kinesiology went from plaudits from his peers to criminal charges of horrific abuse of his wife has notched his third retraction.

As we reported in 2018, Abdeel Safdar, formerly of McMaster University and Harvard, where he was a postdoc, was the subject of an institutional investigation over concerns about the integrity of the data in a pair of his published studies. At the time, journals had flagged only two of his articles, both written with a frequent co-author, Mark Tarnopolsky, of McMaster. Tarnopolsky is considered a leading figure in kinesiology, and together he and Safdar had written some 30 papers.

The newest retraction involves a 2016 article in Skeletal Muscle titled “Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.” Safdar was first author and Tarnopolsky the senior and corresponding author.

According to the retraction notice:

Western University materials scientist committed misconduct, according to investigation

An investigation into the work of a researcher at Western University “resulted in a clear determination of research misconduct,” according to a retraction notice, but details are scant.

Here’s the notice for “Synthetic peptides derived from salivary proteins and the control of surface charge densities of dental surfaces improve the inhibition of dental calculus formation,” published in Materials Science and Engineering: C in 2017 by Bernd Grohe:

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