Harvard cancer lab subject to federal misconduct probe

Sam W. Lee, a Harvard researcher — or perhaps former Harvard researcher — who has lost three papers to retraction, including one from Nature, now has an expression of concern for another article, this one in Molecular and Cellular Biology.

The notice for that paper, 2000’s “Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression,” reads: Continue reading Harvard cancer lab subject to federal misconduct probe

Paper by Harvard cancer biologist flagged over “credible concerns”

A cancer biologist at Harvard who’s issued multiple editorial notices in recent years has received an expression of concern about a 2011 paper, citing “credible concerns” with the data and conclusions.

The publisher does not detail the nature of the issues in the notice.

In the past few years, last author Sam W. Lee lost a Molecular Cell paper in 2013 due to figure duplication and a Journal of Biological Chemistry paper in 2015, citing “manipulated” data in a figure.

Lee also issued two mega-corrections in 2011 in Nature and Current Biology, which also cited figure duplication. Interestingly, both papers were corrected for a second time — the 2006 Current Biology paper in 2016, over figure-related errors, and the 2011 Nature paper in 2015, over concerns the animals used may have experienced excess suffering (prompting an editorial from the journal).

The latest notice, issued by the Journal of Biological Chemistry, doesn’t provide much information for the basis of its expression of concern over Lee’s 2011 paper: Continue reading Paper by Harvard cancer biologist flagged over “credible concerns”

Retraction appears for Harvard scientist who had two mega-corrections last year

molecular cellSam Lee, a Harvard biologist who had two mega-corrections published last year, has retracted a paper in Molecular Cell because some of the figures were “inappropriately assembled.”

Here’s the notice for “GAMT, a p53-Inducible Modulator of Apoptosis, Is Critical for the Adaptive Response to Nutrient Stress:” Continue reading Retraction appears for Harvard scientist who had two mega-corrections last year

Image correction in Current Biology for Harvard’s Sam Lee

The work of Sam W. Lee, a cancer biologist at Harvard and Massachusetts General Hospital, has come under fire at Science Fraud lately over concerns about the possible reuse of images in his group’s published studies.

Turns out there’s some there, there after all. The journal Current Biology has issued a pretty thorny correction for one of Lee’s 2006 articles, “RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress,” citing multiple issues with its figures: Continue reading Image correction in Current Biology for Harvard’s Sam Lee