After university goes silent, diabetes journal retracts three papers

A group of researchers based in Italy has had three papers retracted for likely using the same images to represent different experimental conditions.

The retractions, in Diabetes, published by the American Diabetes Association (ADA), follow expressions of concern for the papers in early 2018 and the launch of an investigation by the authors’ institution into the work. The status of that investigation by Università degli Studi di Napoli Federico II, however, is unclear, as the university has stopped responding to the journal’s inquiries.

Here are the three now-retracted papers:

The ADA requested an investigation by Università degli Studi di Napoli Federico II in November 2017. In February 2018, they issued expressions of concern for the three now-retracted papers.

All three of the new notices contain a paragraph like this one:

In March 2018, the University informed ADA that a three-person committee had been appointed to investigate the issues cited above, but since then the University has not responded to requests for information on the status of the investigation. Therefore, ADA’s Panel on Ethical Scientific Programs (ESP) has independently reviewed these issues. The ESP determined that the concerns cited above are valid and that these and other instances of potential image duplication compromise the overall reliability of the study. ADA has chosen to retract this publication on the basis of the ESP’s assessment.

The corresponding author of the three papers, Francesco Beguinot of Università degli Studi di Napoli Federico II, had another paper retracted in September 2016, this one from the Journal of Cell Science, also for potential duplication. At least two of his papers have been corrected for figure errors.

Beguinot did not respond to a request for comment.

Retraction Watch readers may recall that the ADA earned the first-ever Doing The Right Thing Award, presented by Retraction Watch and STAT, for, among other things, standing up to Mario Saad, a researcher in Brazil who sued them for stamping four of his articles with expressions of concern. Those papers and 14 others of Saad’s have now been retracted.

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41 thoughts on “After university goes silent, diabetes journal retracts three papers”

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    See: https://imgur.com/8JkGQ73

    Refrences:-
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    Editor-in-Chief declares
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    From the standpoint of our journal, the matter is now closed.

    TRF”

    Which data be those?

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    and

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    Erratum in
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    Much more similar than you would expect.

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    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy.

    Figure 1c.

    https://imgur.com/EabJlCk

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    Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano and Istituto di Endocrinologia ed Oncologia Sperimentale del C.N.R., Università degli Studi di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.

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    Dipartimento di Biologia e Patologia Cellulare e Molecolare & Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.

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    Dipartimento di Scienze Ostetrico-Ginecologiche, Urologiche e Medicina della Riproduzione, University of Naples, ‘Frederico II’, Italy.

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    Dipartimento di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Naples, Italy.

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    . Epub 2011 Jan 1.
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    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli Federico II, Naples, Italy.

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    Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy.

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    Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples, 80131, Italy.

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    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy.

    See:
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    Dipartimento di Neuroscienze, Sezione di Psichiatria, Laboratorio di Psichiatria Molecolare, University of Napoli Federico II, Napoli, Italy.

    See:
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    Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Napoli, Italy.

    See:
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    Dipartimento di Biologia e Patologia cellulare e Molecolare (DBPCM), Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.

    See:
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    Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, Via Pansini 5, Naples 80131, Italy.

    See:
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    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Italy.

    See:
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    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del C.N.R., Federico II University of Naples, Naples, Italy.

    See:
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    Dipartimento di Biologia e Patologia Cellulare e Molecolare & Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.

    See:
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    Author information
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    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, 80131 Naples, Italy.

    See:
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    2 comments on PubPeer (by: Peer 1)

    PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.
    Oriente F1, Cabaro S, Liotti A, Longo M, Parrillo L, Pagano TB, Raciti GA, Penkov D, Paciello O, Miele C, Formisano P, Blasi F, Beguinot F.
    Author information
    1
    Department of Translational Medical Sciences, ‘Federico II’ University of Naples and Institute of Experimental Endocrinology and Oncology, National Council of Research, Via Pansini 5, 80131, Naples, Italy.

    See:
    https://pubpeer.com/publications/3468E431F2A4B450DA8D16614FDB0A#1

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    3 comments on PubPeer (by: Peer 1)

    Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells.
    Raciti GA1, Iadicicco C, Ulianich L, Vind BF, Gaster M, Andreozzi F, Longo M, Teperino R, Ungaro P, Di Jeso B, Formisano P, Beguinot F, Miele C.
    Author information
    1
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy.

    See:
    https://pubpeer.com/publications/4E3EF3D1A0F3F04DC1DFCCDE15044B#1

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    2 comments on PubPeer (by: Peer 1)

    In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.
    Cassese A1, Esposito I, Fiory F, Barbagallo AP, Paturzo F, Mirra P, Ulianich L, Giacco F, Iadicicco C, Lombardi A, Oriente F, Van Obberghen E, Beguinot F, Formisano P, Miele C.
    Author information
    1
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Naples 80131, Italy.

    See:
    https://pubpeer.com/publications/7544CBB3E629C9A5D48D5ADD0F848D#2

  29. Pietro Formisano, who is co-author on all 3 retracted papers.

    Endocr Relat Cancer. 2010 May 18;17(2):495-503. doi: 10.1677/ERC-10-0009. Print 2010 Jun.
    2 comments on PubPeer (by: Unregistered Submission, Gnorimus Decempunctatus)

    Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells.
    Laezza C1, Malfitano AM, Proto MC, Esposito I, Gazzerro P, Formisano P, Pisanti S, Santoro A, Caruso MG, Bifulco M.
    Author information
    1
    Institute of Endocrinology e Experimental Oncology, CNR, Via Pansini 5, 80131 Naples, Italy.

    See:
    https://pubpeer.com/publications/D7A6DBC60C7C122E1783EBE87D6DAA#2

  30. Francsco Blasi,who is co-author on the second retraction.
    http://www.jbc.org/content/286/29/25663.long
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    Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade
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    From the ‡Department of Vascular Biology and Thrombosis Research and
    ¶Insitute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria andthe §Department of Molecular Biology and functional Genomics, Dipartimento di Biotechnolgia (DiBiT), San Raffale Scientific Research Institute, 20132 Milan, Italy.

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    IFOM-FIRC Institute of Molecular Oncology Foundation, Milan, Italy.

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    Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and S. Raffaele Scientific Institute, 20132 Milan, Italy.

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    ASIA BAK,1 DOMENICO ACCILI,3 AND SANFORD R. SAMPSON1
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    Gonda-Goldschmeid Diagnostic Center, Faculty of Life Sciences, Bar-Ilan University,
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    Department of Pathology, Sackler School of Medicine,
    Tel-Aviv University, Ramat-Aviv 69978, Israel; and 3
    Columbia University/
    Berrie Research Pavilion, New York, New York 10032.

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    2Division of Signal Transduction, Beth Israel Deaconess Medical Center, Department of Cell Biology,
    Harvard Medical School, Boston, Massachusetts, USA
    3Diabetes Research Unit, Columbia University, New York, New York, USA
    Address correspondence to: C. Ronald Kahn, Research Division, Joslin Diabetes Center,
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    The Journal of Clinical Endocrinology & Metabolism, Volume 85, Issue 5, 1 May 2000, Pages 2004–2013, https://doi.org/10.1210/jcem.85.5.6608

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    Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
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    Department of Medicine, Columbia University, New York, New York, USA.

    See:
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  37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283942/pdf/JCI0526052.pdf
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    Massimo Federici,1,2 Marta L. Hribal,2,3 Rossella Menghini,2 Hiroko Kanno,3 Valentina Marchetti,2
    Ottavia Porzio,2,4 Susan W. Sunnarborg,5 Stefano Rizza,1,2 Matteo Serino,2 Veronica Cunsolo,4
    Davide Lauro,1,2 Alessandro Mauriello,6 David S. Smookler,7 Paolo Sbraccia,1,2 Giorgio Sesti,8
    David C. Lee,5 Rama Khokha,7 Domenico Accili,3 and Renato Lauro1,2
    1Center for Atherosclerosis, “Policlinico Tor Vergata” University Hospital, Rome, Italy. 2Department of Internal Medicine, University of Rome “Tor Vergata,”
    Rome, Italy. 3Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA. 4Clinical Biochemistry Unit,
    Department of Laboratory Medicine, “Policlinico Tor Vergata” University Hospital, Rome, Italy. 5Department of Biochemistry and Biophysics and
    University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. 6Department of Biopathology, University of Rome “Tor Vergata,” and “Policlinico Tor Vergata” University Hospital, Rome, Italy. 7Ontario Cancer Institute, Toronto, Ontario, Canada. 8Department of Clinical and Experimental Medicine, University of Catanzaro, Catanzaro, Italy.

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    https://pubpeer.com/publications/9A406B0F695652D292CA1253932EF9#4

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