Archive for the ‘image manipulation’ Category
“The first author assumes all responsibility:” Malaria vaccine article retracted for image manipulation
Authors of a 2012 article in Infection and Immunity investigating a malaria vaccine strategy are retracting it because it “contains several images that do not accurately reflect the experimental data.”
The paper, “Fine Specificity of Plasmodium vivax Duffy Binding Protein Binding Engagement of the Duffy Antigen on Human Erythrocytes,” has been cited 9 times, according to Thomson Scientific’s Web of Knowledge.
The retraction notice places the blame for the image shenanigans squarely on the first author, Asim Siddiqui, who is currently listed on LinkedIn as a faculty member at the College of Applied Medicine at King Saud University in Saudi Arabia.
There’s been a 10th retraction from two former postdocs at a UT-Southwestern cancer research center who were sanctioned by the Office of Research Integrity (ORI) last September, in part due to observations and comments from Retraction Watch readers.
It’s a 2008 Cancer Letters paper, “Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer,” retracted at the request of Makoto Suzuki, the first author who has claimed responsibility for falsifying data in this and five other papers. Read the rest of this entry »
“[W]e can learn from these bad actors:” Trail of retractions follows former Vanderbilt researcher’s fraud
Authors have retracted three papers from the Journal of Physiology because they contained “falsified or fabricated data.”
The papers, which address calcium signaling in heart muscle cells, are among the six pegged for retraction after an Office of Research Integrity (ORI) investigation into one of the authors, Igor Dzhura, formerly of Vanderbilt University. The ORI found that Dzhura had committed an enormous amount of fraud, involving dozens of faked images and more.
Dzhura was fired from a job at Novartis in November after the company discovered that his application had included the fraudulent work.
The three retracted Journal of Physiology papers and their citation figures, courtesy of Thomson Scientific’s Web of Knowledge, are: Read the rest of this entry »
Cancer biologist Rakesh Kumar has chalked up another retraction, this time for “identical,” “duplicated,” and “replicated” figures and images.
It comes on the heels of a flurry of motions in Kumar’s $8 million lawsuit against his employer, George Washington University, for breach of contract and emotional distress because it removed him as department chair last year and placed his research on hold. Kumar remains employed by the university.
The retracted paper, published in Development in 2004, “Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis,” analyzed the role of a protein, MTA1, in mammary gland development and cancer. It was published while Kumar was at M.D. Anderson in Houston, and has been cited 81 times, according to Thomson Scientific’s Web of Knowledge.
By our count, Kumar now has three retractions and five corrections. Numerous anonymous comments on Kumar’s papers have been posted on PubPeer, many of them critiquing images. Here’s the complete notice from Development: Read the rest of this entry »
Following an investigation into research misconduct, the Journal of Clinical Investigation has retracted a cancer genetics paper from a laboratory at the National Institutes of Health due to “data falsification and fabrication” of four figures and a table in the paper.
The paper, “FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer,” describes an overexpressed gene in mouse prostate cancers that appears to suppress immune system cells.
The journal retracted the paper following an investigation into author Stephanie K. Watkins, then a postdoctoral fellow at the National Cancer Institute. According to a NIH press release released about the study in March 2011, the work “has led to the submission of a patent application by the NIH on behalf of Hurwitz and Watkins to target FOXO3 as a way to boost immune responses in cancer and to silence excessive immune responses in autoimmune diseases.” We found an NIH record of the patent application, but no record of an approved patent at the United States Patent and Trademark Office under either Hurwitz or Watkins’ names.
Stanley Rapoport, a neuroscientist in the National Institute on Aging, isn’t having a lot of luck with his first authors. One committed misconduct and cost him a paper in the journal Age last year, and now he’s lost another paper with a different first author, but for the exact same reason.
The latest paper, in Neurochemical Research, examined whether chronic doses of aspirin reduce brain inflammation. It has been cited 14 times, according to Thomson Scientific’s Web of Knowledge.
Nasser Chegini, the former University of Florida professor currently under investigation by the Office of Research Integrity (ORI), has now had eight papers retracted.
The eighth paper, in the journal Reproductive Biology and Endocrinology, is about the effect of a compound used during fertility treatments on Smads, signaling molecules that carry messages from TGF-beta receptors to the nucleus. It’s being retracted disappeared due to the discovery of data that “have been fabricated or falsified by the last author” — namely, Chegini.
Here’s more from the notice for “Gonadotropin releasing hormone analogue (GnRHa) alters the expression and activation of Smad in human endometrial epithelial and stromal cells:” Read the rest of this entry »
Some of the figures were also reused between the two articles, both in Biochimica et Biophysica Acta General Subjects.
The articles both tested the cancer-fighting properties of a derivative of the active compound present in Boswellia serrata gum resin.
High blood levels of PFOA have been tied to kidney disease in humans, as well as several cancers in animal models. The majority of the U.S. Environmental Protection Agency’s scientific advisory board deemed PFOA “likely to be carcinogenic in humans” in 2006, though a decade later the EPA has yet to make a decision on regulations. The retracted paper found that exposing pregnant mice to PFOA altered hormone pathways in mammary glands.
According to the notice in Toxicological Sciences, there was a duplicated image in one of the figures, as well as “some minor errors.” Here’s figure 5B: Read the rest of this entry »
Sauer had two papers retracted from Science last year following a university investigation. Here’s the Nature notice for “Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1:” Read the rest of this entry »