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Archive for the ‘Paolo Macchiarini’ Category

Karolinska requests retraction of 2014 Macchiarini paper

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Paolo Macchiarini

It has been a tough couple of years for surgeon Paolo Macchiarini, once lauded for pioneering a groundbreaking procedure to transplant tracheas.

After a series of documentaries prompted his former employer, Karolinska Institutet (KI), to reopen a misconduct investigation against him, KI has today released one verdict regarding a 2014 Nature Communications paper: guilty.

KI said it is contacting the journal to request a retraction of the paper, which has already been flagged with an expression of concern.

Here’s more from a release from the institution: Read the rest of this entry »

Macchiarini paper in Nature journal earns expression of concern for data questions

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nature-communications-228x300Nature Communications has issued an expression of concern for a 2014 paper by beleaguered surgeon Paolo Macchiarini, citing concerns over whether the paper accurately reports the experiments that were carried out.

According to the notice, Macchiarini, a former rising star in the field of transplant medicine, agrees with the expression of concern. Three of his 22 co-authors have objected.

Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats” describes transplanting an esophagus into rats that was seeded with their own stem cells, and notes that all animals survived the study period (14 days), and gained more weight than rats given a placebo operation. It’s a topic Macchiarini has made famous, as the first surgeon to perform a similar procedure with a human tracheal transplant. But he’s faced charges of misconduct in the last few years, resulting in his dismissal from Karolinska Institutet (KI).

Here’s the text of the notice, scheduled to go live at 10 a.m. UK time today: Read the rest of this entry »

Meet the filmmakers who cracked open the case against star surgeon Macchiarini

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svtlogo-black_v2Paolo Macchiarini — once a world-renowned surgeon for creating tracheas from cadavers and patients’ own stem cells – has been dogged for years by accusations of misconduct. Officials at his institution, Karolinska Institute, initially cleared him of many charges, but that all changed earlier this year, when Swedish Television (SVT) aired a series of documentaries about Macchiarini and his work. The series alleged, in part, that he operated on patients in Russia whose conditions were not life-threatening enough to warrant such a risky procedure. Such serious accusations caused a media storm, and prompted officials to take a second look at Macchiarini’s work. KI dismissed Macchiarini, and many others have resigned, including KI’s vice chancellor. Recently, two new reports critiqued KI’s role in the case, and Sweden’s Central Ethical Review Board found Macchiarini guilty of misconduct in a 2014 paper. We spoke with SVT producers Bosse Lindquist and Johannes Hallbom via email about the fallout from their series.

Retraction Watch: Your documentary series has caused quite a storm: A series of resignations and renewed investigations have followed. Are you surprised by the reaction? Read the rest of this entry »

Written by Alison McCook

September 12th, 2016 at 3:00 pm

Macchiarini did not obtain necessary ethics approvals, says Swedish Research Council

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lancetSurgeon Paolo Macchiarini did not apply for the necessary ethics approval to perform the pioneering transplants he’s known for, according to the Swedish Research Council.

Chief Legal Counsel Anna Hörnlund, who wrote a letter in this week’s The Lancet, says Macchiarini’s work needed to obtain ethical approval from one of six regional ethical review boards, as required by Swedish law — and neither Macchiarini nor his former employer, Karolinska Institutet, did so:

Read the rest of this entry »

Written by Alison McCook

May 2nd, 2016 at 11:30 am

Poll: Should co-authors of a scientific paper be allowed to change their minds?

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lancetSince we reported Friday that multiple authors had asked to remove their names from a high-profile 2011 Lancet paper about a risky transplant surgery, a few readers have wondered: Should this be allowed?

To recap: The same day the journal announced it was tagging the controversial paper with an expression of concern, it issued a new erratum about the paper, removing three author names (one had already asked to be removed earlier). The highly cited paper has been under scrutiny ever since the last author, Paolo Macchiarini, has been facing allegations of misconduct, which most recently led to Macchiarini’s dismissal from the Karolinska Institutet. (Here’s our timeline of events to keep you abreast.)

It’s not surprising that a few of Macchiarini’s co-authors would want to distance themselves from this ever-expanding scandal, but should authors who originally signed onto a paper be able to change their minds? Let us know in our poll, below. Read the rest of this entry »

Lancet issues expression of concern for 2011 Macchiarini paper

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Paolo Macchiarini

Paolo Macchiarini

The Lancet has tagged an expression of concern onto a seminal 2011 paper by Paolo Macchiarini, the Italian surgeon whose work and conduct outside the operating room has earned months of  heavy criticism that recently culminated in his dismissal from the Karolinska Institutet.

Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study,” which described the first case of a transplant using an artificial trachea seeded with the patient’s own stem cells, now bears an expression of concern from The Lancet editors, citing ongoing investigations. The journal has also removed three more authors from the paper, upon their request.

The expression of concern essentially presents the timeline of the controversy that led the journal to make this move:

Read the rest of this entry »

Macchiarini dismissed from Karolinska

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Paolo Macchiarini

Paolo Macchiarini

The Karolinska Institutet has dismissed former rising star surgeon Paolo Macchiarini from his post, effective immediately.

A KI news release, dated today, states:

The Staff Disciplinary Board at Karolinska Institutet has today decided to relieve Paolo Macchiarini of his duties as a researcher at KI. He is to be informed immediately that his contract has been rescinded.

For a refresher on the story, check out our constantly updating timeline. As a brief recap: Read the rest of this entry »

Written by Alison McCook

March 23rd, 2016 at 7:35 am

Whistleblower removed from Macchiarini’s Lancet author list

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Paolo Macchiarini

Paolo Macchiarini

Last week, The Lancet honored a co-author’s request to remove his name from Paolo Macchiarini’s seminal 2011 paper, which described the first transplant of an artificial trachea seeded with autologous stem cells but has since come under fire.

On March 3, the journal posted this notice:

The Lancet has been contacted by Dr KH Grinnemo who was an author on the paper. Dr Grinnemo no longer wishes to be an author and asks for his name to be removed. This correction has been made to the online version as of March 3, 2016.

The paper has been cited 187 times, designating it “highly cited” by Thomson Reuters Web of Science.

As The Scientist reports, Karl-Henrik Grinnemo is one of the four surgeons at Karolinska Hospital who filed a complaint against Macchiarini in 2014 — alleging, for instance, Read the rest of this entry »

Written by Alison McCook

March 8th, 2016 at 11:30 am

Macchiarini may be dismissed from Karolinska; dean of research resigns

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Paolo Macchiarini

Paolo Macchiarini

There’s more news to report on the story of surgeon Paolo Macchiarini, who’s been dogged by allegations of misconduct.

After the Karolinska Institutet (KI) announced it would not extend his contract and that he needed to “phase out” his research by November, it has now announced it may dismiss him.

In addition, Hans-Gustaf Ljunggren, KI’s Dean of Research, has resigned.

Here’s the statement we received from a KI spokesperson:

Read the rest of this entry »

Written by Alison McCook

February 22nd, 2016 at 4:41 pm

Macchiarini defends ethics of 2011 Lancet paper

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Paolo Macchiarini

Paolo Macchiarini

Embattled trachea surgeon Paolo Macchiarini, who has spent more than a year fighting misconduct allegations, is defending the ethical oversight behind one of his seminal papers published in The Lancet.

The 2011 paper “Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study” described a first-of-its-kind procedure: A 36-year-old man with recurrent tracheal cancer received an artificial airway seeded with his own stem cells. The news launched Macchiarini into the stratosphere. And then the questions came. Read the rest of this entry »

Written by Alison McCook

February 17th, 2016 at 9:30 am

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