Researcher attacks journal for retracting his paper on COVID-19 drug

Flavio Cadegiani

A journal has retracted a paper reporting the results of a clinical trial in which a drug cut COVID-19 hospitalization for men by 90%. 

The research group’s other work has attracted a lot of attention in Brazil – including praise from  president Jair Bolsonaro and criticism from research regulators – for their dramatic results. In a Twitter thread, one of the authors claimed, without evidence, that the journal “may have received bribery to persecute us and retract our study.”

The article, “Proxalutamide Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial,” was published in Frontiers in Medicine last July and has been cited 15 times, according to Clarivate’s Web of Science. 

The study quickly attracted criticism, according to the retraction notice

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AHA “regrets any confusion” and is reviewing meeting policies after outcry over Covid-19 vaccine abstract

Days after a leading heart journal issued an expression of concern for a meeting abstract suggesting that vaccines against Covid-19 may cause cardiac damage, its publisher, the American Heart Association (AHA), says it is reviewing how it screens such submissions. 

As we reported late last month, “Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning,” was presented at the AHA’s 2021 Scientific Sessions in mid-November and was published in Circulation

The author was Steven Gundry, a cardiac surgeon by training who now sells dietary supplements on his website. Gundry also sees patients at the Center for Restorative Medicine and International Heart & Lung Institute in California and offers advice on YouTube. (His critics say what Gundry peddles costs much more than it’s worth.)

After an outcry, Circulation flagged the published poster with the following notice

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What it takes to correct the record: Autopsy of a COVID-19 corrigendum

Richard Jones

We’ve been keeping track of retracted coronavirus papers, but what about corrections? Here’s a guest post from Richard Jones of Cardiff University about a paper that earned widespread media coverage but turned out to be wrong.

According to our best knowledge, this is the first report on COVID-19 infection and death among medical personnel in a Forensic Medicine unit.

So ended a letter from Thailand to the Journal of Forensic and Legal Medicine, accepted on 9th April 2020 within 3 days of receipt, and published as an ubiquitous “Pre-Proof.” 

The authors of that letter stated that there had been only two COVID-19 patients amongst medical personnel in Thailand at that time, one of whom was a “forensic medicine professional” working in Bangkok. 

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French hydroxychloroquine-COVID-19 study withdrawn

The authors of a preprint on use of hydroxychloroquine — the controversial drug heavily promoted by, and now apparently taken by, President Trump, at least for a few more days — along with azithromycin for COVID-19 have withdrawn the paper.

The preprint, “Hydroxychloroquine plus azithromycin: a potential interest in reducing in-hospital morbidity due to COVID-19 pneumonia (HI-ZY-COVID)?” was posted to medRxiv on May 11 by authors at Hopital Raymond Poincare, and sometime yesterday replaced with this statement:

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Covid-19 and sex? Rapid-fire acceptance leads to hasty withdrawal of paper

The Journal of the American Academy of Dermatology has taken down a letter on whether people should abstain from sex during the coronavirus pandemic, but the editor says the article is not being retracted. 

Meanwhile, researchers in France have retracted a paper in which they’d claimed to have found  replication of the virus that causes Covid-19 in the dialysis fluid of a patient with kidney disease. Again, hasty publication appears to be involved. We’ve been tracking retractions of Covid-19 articles on our website, and, let’s just say, the list is almost certainly a trailing indicator of the robustness of the science here — as it is with retractions during any period.

Back to the letter. “COVID-19: Should sexual practices be discouraged during the pandemic?” was written by ZhiQiang Yin, of the Department of Dermatology at the First Affiliated Hospital of Nanjing Medical University, in China. Yin submitted the article on April 14. The journal accepted it on the 16th and published it on April 30th. 

According to the notice

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‘Aggressive’ COVID-19 strains: What it takes to correct a flawed paper

A group of researchers in Scotland have taken aim at a study published in early March which reported surprising findings on the genetics of the SARS-CoV-2 virus responsible for the Covid-19 pandemic. 

But the story of what it took to correct the record about the paper is likely to be all too familiar to those who attempt such feats. It involved a blog post and a new paper — neither of which appeared on the site of the original journal that published the work, and neither of which is seeing the kind of attention paid to the original article.

The paper, “On the origin and continuing evolution of SARS-CoV-2,” appeared in National Science Review, published by Oxford Academic. According to the abstract

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Authors to correct influential Imperial College COVID-19 report after learning it cited a withdrawn preprint

A March paper by researchers at Imperial College London that, in the words of the Washington Post, “helped upend U.S. and U.K. coronavirus strategies,” cited a preprint that had been withdrawn.

Retraction Watch became aware of the issue after being contacted by a PubPeer commenter who had noted the withdrawal earlier this month. Following questions from Retraction Watch this weekend, the authors said they plan to submit a correction.

In March, the New York Times wrote:

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Elsevier investigating hydroxychloroquine-COVID-19 paper

Elsevier has weighed in on the handling of a controversial paper about the utility of hydroxychloroquine to treat Covid-19 infection, defending the rigor of the peer review process for the article in the face of concerns that the authors included the top editor of the journal that published the work. 

On April 3, as we reported, the International Society of Antimicrobial Chemotherapy issued an expression of concern (without quite calling it that) about the paper, which had appeared in March in the International Journal of Antimicrobial Agents, which the ISAC publishes, along with Elsevier. According to the society, the article, by the controversial French scientist  Didier Raoult, of the University of Marseille, and colleagues:

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Hydroxychloroquine-COVID-19 study did not meet publishing society’s “expected standard”

The paper that appears to have triggered the Trump administration’s obsession with hydroxychloroquine as a treatment for infection with the novel coronavirus has received a statement of concern from the society that publishes the journal in which the work appeared. 

The April 3, 2020, notice, from the International Journal of Antimicrobial Agents, states that the March 20 article, “Hydroxychloroquine and azithromycin as a treatment of Covid-19: results of an open-label non-randomized clinical trial” 

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