Category: image manipulation

University requests 20 retractions of cancer papers following probe

Santosh Katiyar

A university and medical center have requested a batch of retractions following an investigation that found 20 papers by a cancer researcher contained manipulated images.

The request, from University of Alabama, Birmingham (UAB) and Birmingham VA Medical Center, focuses on papers by Santosh Katiyar, who explored alternative approaches to treating skin cancer in animal models.

For more, see our story out today in The Scientist.

Continue reading University requests 20 retractions of cancer papers following probe

Mount Sinai multiple sclerosis researcher admits to misconduct

Gareth John

A researcher who has received millions in funding from the U.S. National Institutes of Health and who runs a lab at the Icahn School of Medicine at Mount Sinai in New York has confessed to falsifying data in a 2014 paper.

Gareth John, who studies multiple sclerosis and other neurological diseases, “has expressed remorse for his actions,” according to a report released last week from the U.S. Department of Health and Human Services’ Office of Research Integrity. Continue reading Mount Sinai multiple sclerosis researcher admits to misconduct

Controversial Australian science journalist admits to duplication in her PhD thesis

Maryanne Demasi

A prominent (yet controversial) journalist in Australia has admitted to duplicating three images that were part of her PhD thesis — a practice outside experts agreed was acceptable, if not ideal, at the time, according to a report released today.

As part of an inquiry, the University of Adelaide convened an expert panel to investigate 17 allegations of duplication and/or manipulation in Maryanne Demasi’s 2004 thesis. Duplication is a common reason for retractions, such as when researchers use the same image to depict the results of different experiments.

After earning her PhD in rheumatology, Demasi became a journalist who got headlines for more than just her reporting. In 2013, she produced a controversial series about cholesterol and fat (which suggested they have been unfairly villainized, and which cast doubt on cholesterol-lowering drugs known as statins). A few years later, Demasi was fired from the science program Catalyst, after it aired an episode alleging wi-fi could cause brain tumors.

Regarding the allegations of misconduct in Demasi’s thesis, the originals of the images in question were long gone, so in 14 instances, an expert concluded it was not possible to conclude whether or not duplication had occurred. But in the remaining three instances, Demasi admitted she had “duplicated or probably duplicated” the images:

Continue reading Controversial Australian science journalist admits to duplication in her PhD thesis

Researcher loses battle with Cell over wording of retraction notice

For months, a researcher has wrestled with a journal over the wording of an upcoming retraction notice. It appears that she has lost.

Earlier this week, Cell retracted the paper, despite the protests of first author Shalon Babbitt Ledbetter. When Ledbetter learned the journal was planning to retract the biochemistry paper over image manipulations, but wouldn’t name the culprit in the notice, she shared her concerns on PubPeer. Although a 2015 letter sent to Cell from Saint Louis University identified last author Dorota Skowyra as responsible for multiple manipulations, the journal wasn’t planning to say Skowyra was responsible in the retraction notice. Which would leave all other authors — particularly Ledbetter — under a cloud of suspicion.

Now, Cell Press has finally retracted the paper, along with another paper in Molecular Cell that lists Skowyra as corresponding author. Both notices describe image manipulations that were investigated by Saint Louis University (SLU). Neither identifies who is responsible.

Continue reading Researcher loses battle with Cell over wording of retraction notice

Caught Our Notice: 54 problems in three scientific images equals one expression of concern

Title: Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain

What Caught Our Attention: Usually, an Expression of Concern (EOC) offers general language about “concerns regarding the validity of the data” or “concerns regarding the integrity of the study.” Here the language is anything but, saying that 54 Western blot bands within three figures have problems such as “visible pasted joints,” “square border,” and numerous “appear to be the same band.”  According to the notice, the authors have not responded to requests for the original blots, so the editors are allowing the article to remain intact, choosing instead “to alert readers to these issues and allow them to arrive at their own conclusions regarding the figures.” Continue reading Caught Our Notice: 54 problems in three scientific images equals one expression of concern

In what appears to be a first, researcher sanctioned twice by ORI

Here’s something we haven’t seen before: The U.S. Office of Research Integrity has issued a second notice for a former researcher at the National Institutes of Health, after determining she withheld information during the first investigation.

Last year, the ORI sanctioned Brandi M. Baughman — formerly at the National Institute of Environmental and Health Sciences — after she “falsified and/or fabricated data” in 11 figures in a 2016 paper. Sanctions included agreeing to have her research supervised for three years. Now, the agency has barred her from receiving federal grants for two years. The reason:

Continue reading In what appears to be a first, researcher sanctioned twice by ORI

What if we could scan for image duplication the way we check for plagiarism?

Paul Brookes

Paul Brookes is a biologist with a passion for sleuthing out fraud. Although he studies mitochondria at the University of Rochester, he also secretly ran a science-fraud.org, a site for people to post their concerns about papers. Following legal threats, he revealed he was the author and shut the site in 2013 — but didn’t stop the fight. Recently, he’s co-authored a paper that’s slightly outside his day job: Partnering with computer scientist Daniel Acuna at Syracuse University and computational biologist Konrad Kording at the University of Pennsylvania, they developed a software to help detect duplicated images. If it works, it would provide a much needed service to the research community, which has been clamoring for some version of this for years. So how did this paper — also described by Nature News — come about?

Retraction Watch: Dr. Brookes, you study mitochondria. What brought you to co-author a paper about software to detect duplications?

Continue reading What if we could scan for image duplication the way we check for plagiarism?

Caught Our Notice: Duplicates, errors prompt two retractions for same author

Titles: 1) Angiopoietin-Like 4 Confers Resistance to Hypoxia/Serum Deprivation-Induced Apoptosis through PI3K/Akt and ERK1/2 Signaling Pathways in Mesenchymal Stem Cells

2) Novel Mechanism of Inhibition of Dendritic Cells Maturation by Mesenchymal Stem Cells via Interleukin-10 and the JAK1/STAT3 Signaling Pathway

What Caught Our Attention: In the span of 48 hours, PLOS ONE retracted two papers this month that were co-authored by Bo Yu, based at Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment and The Second Affiliated Hospital of Harbin Medical University in China. Both notices cite multiple duplications and errors, and conclude:

Continue reading Caught Our Notice: Duplicates, errors prompt two retractions for same author

Caught Our Notice: Yes, a 20-year-old article is wrong — but it won’t be corrected online

Title: AMPA receptor-mediated regulation of a Gi-protein in cortical neurons

What Caught Our Attention:  Usually, when journals publish corrections to articles, they also correct the original article, except when the original is unavailable online.  When Nature noticed that some figure panels in a 20-year-old paper were duplicated, it flagged the issue for readers — but didn’t correct the online version of the original paper. According to the notice, the duplications don’t disturb the conclusion illustrated by the figure, the original data couldn’t be found, and the last two authors had retired. We contacted a spokesperson at Nature, who told us “the information at the start of the paper clearly links to the corrigendum.”   Continue reading Caught Our Notice: Yes, a 20-year-old article is wrong — but it won’t be corrected online

Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Title: A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins

What Caught Our Attention: Here’s a cut-and-paste issue that gave us pause. The authors of an 18-year-old paper in PNAS corrected it after realizing some bands in a figure were duplicated (an issue raised on PubPeer one year ago). It turns out, the first author had cut the paper into pieces and reassembled them to present the blots in the “desired order,” and some had become duplicated by mistake. The overall results were unaffected, so the journal swapped the image with a corrected version. Continue reading Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”