Clinical trial paper that made anemia drug look safer than it is will be retracted

via Kidney International Reports

A study that a pharmaceutical company admitted last month included manipulated data will be retracted, Retraction Watch has learned.

The paper, “Pooled Analysis of Roxadustat for Anemia in Patients With Kidney Failure Incident to Dialysis,” was published in Kidney International Reports in December 2020. The study analyzed data from a clinical trial for roxadustat, a drug intended to help anemic patients make more red blood cells. The medicine was tested in more than 1,500 patients with kidney failure that had been on dialysis for less than four months.

The paper compared roxadustat to a standard treatment, epoetin alfa. Epoetin alfa is not given to anemic patients who have kidney disease and are not dependent on dialysis, according to reporting in April by FiercePharma, because it can increase the risk of a cardiovascular event, including heart attacks.

In the study, roxadustat was as effective as epoetin alfa for these patients, but carried a 30 percent lower risk for death, heart attacks or strokes.

Then, on April 6th, Fibrogen announced, according to FiercePharma, that researchers had

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Rejection overruled, retraction ensues when annoyed reviewer does deep dive into data

Kim Rossmo

As a prominent criminologist, Kim Rossmo often gets asked to review manuscripts. So it was that he found himself reviewing a meta-analysis by a pair of Dutch researchers — Wim Bernasco and Remco van Dijke, of the Netherlands Institute for the Study of Crime and Law Enforcement, in Amsterdam — looking at a phenomenon called the buffer zone hypothesis. In this framework, criminals are thought to avoid committing offenses near their own homes. 

The paper, for Crime Science, analyzed 33 studies, of which, according to the authors, 11 confirmed the hypothesis and 22 rejected it. 

Rossmo, who holds the University Chair in Criminology and directs the Center for Geospatial Intelligence and Investigation in the School of Criminal Justice and Criminology at Texas State University in San Marcos, told us:

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Paper on ‘energy medicine’ retracted after reader complaints

Christina Ross

An integrative health journal has retracted a 2019 paper two months after issuing an expression of concern about the article distancing itself from the work. 

The paper, which appeared in Global Advances in Health and Medicine, was a review of “energy medicine” by Christina Ross, of Wake Forest University in Winston-Salem, N.C. 

As we reported in March, Ross told us that a reader in England complained to the journal for her suggestion in the paper: 

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Paper partly funded by controversial stem cell company retracted

The timestamps always get you in the end. 

A widely touted 2017 paper linked to a controversial company promoting regenerative medicine has been retracted after the journal came to doubt the validity of the data thanks to some strange anachronisms and a digital breadcrumb. 

Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis,” appeared in the Journal of Translational Medicine to no small notice. 

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Mask study was “misleading” and misquotes citations, says Elsevier

Three days after we reported that Elsevier would be retracting a paper about COVID-19 and masks whose author claimed a false affiliation with Stanford, the publisher tells us that the “paper is misleading,” “misquotes and selectively cites published papers,” and that the data in one table is “unverified.”

As we noted earlier this week:

The 2020 paper, “Facemasks in the COVID-19 era: A health hypothesis,” was written by Baruch Vainshelboim, who listed his affiliation as Stanford University and the VA Palo Alto Health System. But the study gained wide circulation earlier this month, thanks in part to some conservative politicians, and became the subject of fact-checks by the Associated Press and Snopes

Here is Elsevier’s statement in full:

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“[N]o intention to make any scientific fraud” as researchers lose four papers

Researchers in India have lost four papers in journals belonging to the Royal Society of Chemistry over concerns that the images in the articles appear to have been doctored. 

The senior author on the articles is  Pralay Maiti, of the School of Material Science & Technology at Banaras Hindu University, in Varanasi. 

Polycaprolactone composites with TiO2 for potential nanobiomaterials: tunable properties using different phases” was published in 2012 in Physical Chemistry Chemical Physics, and has been cited 65 times, according to Clarivate Analytics’ Web of Science. According to the retraction notice:

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One in six of the papers you cite in a review has been retracted. What do you do?

The author of a 2014 review article about the role of vitamin D in Parkinson’s disease has alerted readers to the fact that roughly one-sixth of her references have since been retracted. But she and the journal are not retracting the review itself. 

The paper, “A review of vitamin D and Parkinson’s disease,” appeared in Elsevier’s Maturitas, which is the official journal of the European Menopause and Andropause Society. The author is Amie Hiller, a neurologist at Oregon Health & Science University in Portland, and the work has been cited 26 times, according to Clarivate Analytics’ Web of Science. 

According to Hiller, she recently became aware that 10 of the 63 references in her article were to papers by Yoshihiro Sato, a bone researcher in Japan whose 103 retractions put him in the third position on the Retraction Watch leaderboard. Sato’s misdeeds run from lack of IRB approval to fabrication of data, in articles dating back to the mid-1990s. 

Hiller’s letter on the subject, recently published in Maturitas but not linked from the original review, states that: 

Continue reading One in six of the papers you cite in a review has been retracted. What do you do?

Beam us up! Elsevier pulls 26 Covid-19 papers by researcher with a penchant for Star Trek

An Elsevier journal has retracted more than two dozen Covid-19 papers by a researcher in Malta with a fondness for Star Trek after determining that the articles did not meet its standards for publication.  

The move comes several months after we reported that Hampton Gaddy, a student at the University of Oxford, had raised questions about more than 100 articles written by a pediatric cardiologist named Victor Grech. The papers appeared in Early Human Development (EHD), which Grech managed to turn into something of a vanity press — including for papers about how the lessons of Star Trek shed light on everything from the evolving role of nurses to the horrors of Nazi doctors. 

As Gaddy pointed out to Elsevier last December, Grech has written at least 113 papers in EHD, 57 as sole author: 

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Author, Author! Or perhaps we should say Fake Author, Fake Author!

The wrong David Ross (and his wife Sara)

Researchers in Iran have lost their 2019 paper on nanofluids after the journal learned that their list of authors included an engineer at the University of Texas who had nothing to do with the work. 

The article, “Numerical study on free convection in a U-shaped CuO/water nanofluid-filled cavity with different aspect ratios using double-MRT lattice Boltzmann,” was published in Thermal Science and Engineering Progress, an Elsevier journal. The first author was Ahmad Fard, of the Faculty of Aerospace Engineering at K.N. Toosi University of Technology, in Tehran.

Batting cleanup was David Ross, whose affiliation is given as the University of Texas at Austin. A David Ross — no, not the Cubs manager and former Major League Baseball catcher — was on the faculty of UT from 1966 until his retirement in 2003.

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Editor who opined on author excuses has paper subjected to an expression of concern

A study co-authored by an editor who has previously opined on common excuses by authors about research misconduct has received an expression of concern.

The paper’s first author defended the work, explaining that the experiments in question were repeated multiple times, and that the results are “valid and reproducible.”

The study, titled, “CK1δ modulates the transcriptional activity of ERα via AIB1 in an estrogen-dependent manner and regulates ERα–AIB1 interactions,” was published in Nucleic Acids Research in April 2009. It has been cited 20 times, according to Clarivate Analytics’ Web of Science.

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