A group of researchers based in Italy has had three papers retracted for likely using the same images to represent different experimental conditions.
The retractions, in Diabetes, published by the American Diabetes Association (ADA), follow expressions of concern for the papers in early 2018 and the launch of an investigation by the authors’ institution into the work. The status of that investigation by Università degli Studi di Napoli Federico II, however, is unclear, as the university has stopped responding to the journal’s inquiries.
Here are the three now-retracted papers:
- “The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver,” cited 10 times, according to Clarivate Analytics’ Web of Science
- “Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase,” cited 25 times
- “Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells,” cited 54 times
The ADA requested an investigation by Università degli Studi di Napoli Federico II in November 2017. In February 2018, they issued expressions of concern for the three now-retracted papers.
All three of the new notices contain a paragraph like this one:
In March 2018, the University informed ADA that a three-person committee had been appointed to investigate the issues cited above, but since then the University has not responded to requests for information on the status of the investigation. Therefore, ADA’s Panel on Ethical Scientific Programs (ESP) has independently reviewed these issues. The ESP determined that the concerns cited above are valid and that these and other instances of potential image duplication compromise the overall reliability of the study. ADA has chosen to retract this publication on the basis of the ESP’s assessment.
The corresponding author of the three papers, Francesco Beguinot of Università degli Studi di Napoli Federico II, had another paper retracted in September 2016, this one from the Journal of Cell Science, also for potential duplication. At least two of his papers have been corrected for figure errors.
Beguinot did not respond to a request for comment.
Retraction Watch readers may recall that the ADA earned the first-ever Doing The Right Thing Award, presented by Retraction Watch and STAT, for, among other things, standing up to Mario Saad, a researcher in Brazil who sued them for stamping four of his articles with expressions of concern. Those papers and 14 others of Saad’s have now been retracted.
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Data figure 2c Cell Death Differ. 2012 Jul;19(7):1127-38 from figures 4A and 6D (where is presents different things) J Biol Chem. 2005 Dec 9;280(49):40642-9.
See: https://imgur.com/8JkGQ73
Refrences:-
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7 comments on PubPeer (by: Unregistered Submission, Peer 1, Chorthippus Binotatus)
PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation.
Iovino S1, Oriente F, Botta G, Cabaro S, Iovane V, Paciello O, Viggiano D, Perruolo G, Formisano P, Beguinot F.
Author information
1
Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, Italy.
2. J Biol Chem. 2005 Dec 9;280(49):40642-9. Epub 2005 Oct 10.
Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon.
Oriente F1, Andreozzi F, Romano C, Perruolo G, Perfetti A, Fiory F, Miele C, Beguinot F, Formisano P.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, Italy.
J Biol Chem. 1997 Mar 14;272(11):7290-7.
In skeletal muscle, glucose storage and oxidation are differentially impaired by the IR1152 mutant receptor.
Caruso M1, Miele C, Formisano P, Condorelli G, Bifulco G, Oliva A, Auricchio R, Riccardi G, Capaldo B, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare “L. Califano” and Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R., “Federico II” University of Naples Medical School, 80131 Naples, Italy.
See: https://pubpeer.com/publications/1A85B0C35BE05D99D8B01052B6072F#2
and
https://pubpeer.com/publications/1A85B0C35BE05D99D8B01052B6072F#3
Hum Gene Ther. 2012 Jun;23(6):623-34. doi: 10.1089/hum.2011.120. Epub 2012 Jun 5.
8 comments on PubPeer (by: Unregistered Submission, Peer 2, Hygrobates Calliger, Dactylogyrus Dyki)
Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo.
Botta G1, Passaro C, Libertini S, Abagnale A, Barbato S, Maione AS, Hallden G, Beguinot F, Formisano P, Portella G.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università Federico II, 80131, Naples, Italy.
See:https://pubpeer.com/publications/BB33AB1C5572A6EAAF5A34FAE42EAB#3
Editor-in-Chief declares
“I have now reviewed all of the original data files from all of Dr. Portella’s figure panels (mentioned below). I do not find any evidence of falsification or tampering, as judged by the data available to us.
From the standpoint of our journal, the matter is now closed.
TRF”
Which data be those?
EMBO J. 1998 Jul 15;17(14):3858-66.
PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.
Condorelli G1, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F, Cafieri A, Tecce MF, Formisano P, Beguinot L, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare and Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R., Federico II University of Naples, Naples, Italy.
and
Mol Cell Biol. 2000 Sep;20(17):6323-33.
Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells.
Formisano P1, Oriente F, Fiory F, Caruso M, Miele C, Maitan MA, Andreozzi F, Vigliotta G, Condorelli G, Beguinot F.
Author information
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Dipartimento di Biologia e Patologia Cellulare e Molecolare and Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, Naples 80131, Italy.
Erratum in
Mol Cell Biol. 2013 Apr;33(7):1474.
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https://pubpeer.com/publications/A028CE3881C3B25BF40DBE9F260105#5
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Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner.
De Vitis S1, Sonia Treglia A, Ulianich L, Turco S, Terrazzano G, Lombardi A, Miele C, Garbi C, Beguinot F, Di Jeso B.
Author information
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Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Facoltà di Scienze Matematiche Fisiche e Naturali, Università degli Studi del Salento, Lecce, Italy.
See: https://pubpeer.com/publications/8163C613EBBE8BCD66E2E94D3F125D#2
J Biol Chem. 2010 Feb 26;285(9):6563-72. doi: 10.1074/jbc.M109.097410. Epub 2009 Dec 31.
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Alberobello AT1, D’Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, 80131 Naples, Italy.
See:
https://pubpeer.com/publications/FDC79C30DEAC010EDA7E033F6276BD#2
https://pubpeer.com/publications/FDC79C30DEAC010EDA7E033F6276BD#3
Oncogene. 2005 Oct 27;24(47):7012-21.
Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.
Formisano P1, Perruolo G, Libertini S, Santopietro S, Troncone G, Raciti GA, Oriente F, Portella G, Miele C, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via Sergio Pansini, 5, Naples 80131, Italy.
Much more similar than you would expect.
See:
https://pubpeer.com/publications/85E11C2829C830C4E4B1CC2F04B0C4
Mol Cell Biol. 2004 Jun;24(11):5005-15.
Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action.
Vigliotta G1, Miele C, Santopietro S, Portella G, Perfetti A, Maitan MA, Cassese A, Oriente F, Trencia A, Fiory F, Romano C, Tiveron C, Tatangelo L, Troncone G, Formisano P, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy.
Figure 1c.
https://imgur.com/EabJlCk
J Biol Chem. 2004 Mar 19;279(12):11137-45. Epub 2004 Jan 6.
Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting.
Fiory F1, Oriente F, Miele C, Romano C, Trencia A, Alberobello AT, Esposito I, Valentino R, Beguinot F, Formisano P.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano and Istituto di Endocrinologia ed Oncologia Sperimentale del C.N.R., Università degli Studi di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.
See: https://pubpeer.com/publications/B3C62B5370FAE82B9172F6341ACDFB#2
https://pubpeer.com/publications/B3C62B5370FAE82B9172F6341ACDFB#3
J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.
Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.
Miele C1, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare & Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.
See: https://pubpeer.com/publications/8AACA78328F544363C3DFD82EDC225
Mol Hum Reprod. 2004 Jan;10(1):43-8.
Molecular mechanisms involved in GnRH analogue-related apoptosis for uterine leiomyomas.
Bifulco G1, Miele C, Pellicano M, Trencia A, Ferraioli M, Paturzo F, Tommaselli GA, Beguinot F, Nappi C.
Author information
1
Dipartimento di Scienze Ostetrico-Ginecologiche, Urologiche e Medicina della Riproduzione, University of Naples, ‘Frederico II’, Italy.
See: https://pubpeer.com/publications/3B7E5BE55C44B97C513A22E0F2B1DE
Placenta. 2003 Apr;24(4):385-91.
Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion.
Bifulco G1, Trencia A, Caruso M, Tommaselli GA, Miele C, di Carlo C, Beguinot F, Nappi C.
Author information
1
Dipartimento di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Naples, Italy.
See:
https://pubpeer.com/publications/BD2E2E03C7E035F92082905211698D
J Biol Chem. 2002 Jul 5;277(27):24306-14. Epub 2002 Apr 30.
Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells.
Bifulco G1, Di Carlo C, Caruso M, Oriente F, Di Spiezio Sardo A, Formisano P, Beguinot F, Nappi C.
Author information
1
Dipartimento di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
See: https://pubpeer.com/publications/31444DCA2847E1A0C580F84F3CE5C4
Biochim Biophys Acta. 2011 Apr;1812(4):431-8. doi: 10.1016/j.bbadis.2010.12.013
2 comments on PubPeer (by: Peer 1)
. Epub 2011 Jan 1.
ER stress impairs MHC Class I surface expression and increases susceptibility of thyroid cells to NK-mediated cytotoxicity.
Ulianich L1, Terrazzano G, Annunziatella M, Ruggiero G, Beguinot F, Di Jeso B.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli Federico II, Naples, Italy.
See: https://pubpeer.com/publications/708A1B6A465BAC99670C0D65676B79#1
Diabetologia. 2009 Dec;52(12):2642-52. doi: 10.1007/s00125-009-1528-z. Epub 2009 Sep 30.
4 comments on PubPeer (by: Peer 1, Peer 2)
Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.
Oriente F1, Iovino S, Cassese A, Romano C, Miele C, Troncone G, Balletta M, Perfetti A, Santulli G, Iaccarino G, Valentino R, Beguinot F, Formisano P.
Author information
1
Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy.
See:
https://pubpeer.com/publications/F90A3F32DD0BED8AEF0B2CA17D5BEA
Diabetologia. 2010 Jul;53(7):1482-92. doi: 10.1007/s00125-010-1732-x. Epub 2010 Apr 16.
3 comments on PubPeer (by: Peer 1)
Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene.
Ungaro P1, Teperino R, Mirra P, Longo M, Ciccarelli M, Raciti GA, Nigro C, Miele C, Formisano P, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples, 80131, Italy.
See:
https://pubpeer.com/publications/2212F7C0D8F0B259FC5F7F4EF3AA83#1
Mol Cell Biol. 2008 Sep;28(18):5634-45. doi: 10.1128/MCB.00117-08. Epub 2008 Jul 21.
10 comments on PubPeer (by: Unregistered Submission, Peer 1, Peer 3)
Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
Oriente F1, Fernandez Diaz LC, Miele C, Iovino S, Mori S, Diaz VM, Troncone G, Cassese A, Formisano P, Blasi F, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy.
See:
https://pubpeer.com/publications/D59B70196AA6950ACD20C8F812CD58#2
J Cell Physiol. 2012 Apr;227(4):1485-92. doi: 10.1002/jcp.22864.
4 comments on PubPeer (by: Unregistered Submission, Peer 1)
Clozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance.
Panariello F1, Perruolo G, Cassese A, Giacco F, Botta G, Barbagallo AP, Muscettola G, Beguinot F, Formisano P, de Bartolomeis A.
Author information
1
Dipartimento di Neuroscienze, Sezione di Psichiatria, Laboratorio di Psichiatria Molecolare, University of Napoli Federico II, Napoli, Italy.
See:
https://pubpeer.com/publications/62B56E9156D5E424AA1953707667B6#2
and
https://pubpeer.com/publications/62B56E9156D5E424AA1953707667B6#3
Mol Pharmacol. 2008 Dec;74(6):1678-86. doi: 10.1124/mol.108.049205. Epub 2008 Sep 18.
4 comments on PubPeer (by: Unregistered Submission, Peer 2)
The cannabinoid CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase.
Esposito I1, Proto MC, Gazzerro P, Laezza C, Miele C, Alberobello AT, D’Esposito V, Beguinot F, Formisano P, Bifulco M.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Napoli, Italy.
See:
https://pubpeer.com/publications/7F884DDDD8540B52614FD29B42A25B#2
and
https://pubpeer.com/publications/7F884DDDD8540B52614FD29B42A25B#3
J Biol Chem. 2007 Mar 23;282(12):8648-57. Epub 2007 Jan 16.
Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.
Perfetti A1, Oriente F, Iovino S, Alberobello AT, Barbagallo AP, Esposito I, Fiory F, Teperino R, Ungaro P, Miele C, Formisano P, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia cellulare e Molecolare (DBPCM), Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.
See:
https://pubpeer.com/publications/5E2DBDCE70468FB14E5EDACD296A44#2
and
https://pubpeer.com/publications/5E2DBDCE70468FB14E5EDACD296A44#3
J Biol Chem. 2007 Nov 2;282(44):31835-43. Epub 2007 Aug 3.
Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization.
Miele C1, Paturzo F, Teperino R, Sakane F, Fiory F, Oriente F, Ungaro P, Valentino R, Beguinot F, Formisano P.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, Via Pansini 5, Naples 80131, Italy.
See:
https://pubpeer.com/publications/F3B6855214545D8F5794E759239A7E#2
Mol Cell Biol. 2005 Dec;25(24):10803-14.
Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.
Fiory F1, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Italy.
See:
https://pubpeer.com/publications/251C391FBE7ED6E3AB831832212BE5
Mol Cell Biol. 2003 Jul;23(13):4511-21.
Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.
Trencia A1, Perfetti A, Cassese A, Vigliotta G, Miele C, Oriente F, Santopietro S, Giacco F, Condorelli G, Formisano P, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del C.N.R., Federico II University of Naples, Naples, Italy.
See:
https://pubpeer.com/publications/A0A5C9304F27D2DD3B1B83D1D852EA#2
J Biol Chem. 2002 Mar 29;277(13):11013-8. Epub 2002 Jan 14.
Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function.
Condorelli G1, Trencia A, Vigliotta G, Perfetti A, Goglia U, Cassese A, Musti AM, Miele C, Santopietro S, Formisano P, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare & Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.
See:
https://pubpeer.com/publications/F755FA7C1DC92D8CCCABA81F752FC4#2
https://pubpeer.com/publications/F755FA7C1DC92D8CCCABA81F752FC4#3
https://pubpeer.com/publications/F755FA7C1DC92D8CCCABA81F752FC4#4
and
https://pubpeer.com/publications/F755FA7C1DC92D8CCCABA81F752FC4#5
J Biol Chem. 2001 Nov 30;276(48):45088-97. Epub 2001 Sep 27.
Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells.
Caruso M1, Maitan MA, Bifulco G, Miele C, Vigliotta G, Oriente F, Formisano P, Beguinot F.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare and Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, 80131 Naples, Italy.
See:
https://pubpeer.com/publications/7E566011F6C1EB22DFCFB8BC6E67A7#3
https://pubpeer.com/publications/7E566011F6C1EB22DFCFB8BC6E67A7#4
https://pubpeer.com/publications/7E566011F6C1EB22DFCFB8BC6E67A7#5
https://pubpeer.com/publications/7E566011F6C1EB22DFCFB8BC6E67A7#6
and
https://pubpeer.com/publications/7E566011F6C1EB22DFCFB8BC6E67A7#7
Diabetologia. 2013 Dec;56(12):2713-22. doi: 10.1007/s00125-013-3053-3. Epub 2013 Sep 20.
2 comments on PubPeer (by: Peer 1)
PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.
Oriente F1, Cabaro S, Liotti A, Longo M, Parrillo L, Pagano TB, Raciti GA, Penkov D, Paciello O, Miele C, Formisano P, Blasi F, Beguinot F.
Author information
1
Department of Translational Medical Sciences, ‘Federico II’ University of Naples and Institute of Experimental Endocrinology and Oncology, National Council of Research, Via Pansini 5, 80131, Naples, Italy.
See:
https://pubpeer.com/publications/3468E431F2A4B450DA8D16614FDB0A#1
Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
3 comments on PubPeer (by: Peer 1)
Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells.
Raciti GA1, Iadicicco C, Ulianich L, Vind BF, Gaster M, Andreozzi F, Longo M, Teperino R, Ungaro P, Di Jeso B, Formisano P, Beguinot F, Miele C.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy.
See:
https://pubpeer.com/publications/4E3EF3D1A0F3F04DC1DFCCDE15044B#1
J Biol Chem. 2008 Dec 26;283(52):36088-99. doi: 10.1074/jbc.M801698200. Epub 2008 Oct 27.
2 comments on PubPeer (by: Peer 1)
In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.
Cassese A1, Esposito I, Fiory F, Barbagallo AP, Paturzo F, Mirra P, Ulianich L, Giacco F, Iadicicco C, Lombardi A, Oriente F, Van Obberghen E, Beguinot F, Formisano P, Miele C.
Author information
1
Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Naples 80131, Italy.
See:
https://pubpeer.com/publications/7544CBB3E629C9A5D48D5ADD0F848D#2
Pietro Formisano, who is co-author on all 3 retracted papers.
Endocr Relat Cancer. 2010 May 18;17(2):495-503. doi: 10.1677/ERC-10-0009. Print 2010 Jun.
2 comments on PubPeer (by: Unregistered Submission, Gnorimus Decempunctatus)
Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells.
Laezza C1, Malfitano AM, Proto MC, Esposito I, Gazzerro P, Formisano P, Pisanti S, Santoro A, Caruso MG, Bifulco M.
Author information
1
Institute of Endocrinology e Experimental Oncology, CNR, Via Pansini 5, 80131 Naples, Italy.
See:
https://pubpeer.com/publications/D7A6DBC60C7C122E1783EBE87D6DAA#2
Francsco Blasi,who is co-author on the second retraction.
http://www.jbc.org/content/286/29/25663.long
July 22, 2011 286, 25663-25674.
Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade
CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)*
Nishamol Geetha‡, Judit Mihaly‡, Alexander Stockenhuber‡, Francesco Blasi§, Pavel Uhrin‡, Bernd R. Binder‡†, Michael Freissmuth¶,1 and Johannes M. Breuss‡
– Author Affiliations
From the ‡Department of Vascular Biology and Thrombosis Research and
¶Insitute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria andthe §Department of Molecular Biology and functional Genomics, Dipartimento di Biotechnolgia (DiBiT), San Raffale Scientific Research Institute, 20132 Milan, Italy.
See:
https://pubpeer.com/publications/C79DC1542BE0259FC4DB47F3568ABF#2
and
https://pubpeer.com/publications/C79DC1542BE0259FC4DB47F3568ABF#3
PLoS One. 2010 Dec 22;5(12):e15047. doi: 10.1371/journal.pone.0015047
6 comments on PubPeer (by: Unregistered Submission, Peer 2)
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Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.
Bernardi E1, Deflorian G, Pezzimenti F, Diaz VM, Mione M, Blasi F.
Author information
1
IFOM-FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
See:
https://pubpeer.com/publications/54D2D3ADF6FC084C858BB70E597CEC#3
and
https://pubpeer.com/publications/54D2D3ADF6FC084C858BB70E597CEC#5
Mol Biol Cell. 2006 Jan;17(1):367-78. Epub 2005 Nov 2.
An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.
Mazzieri R1, D’Alessio S, Kenmoe RK, Ossowski L, Blasi F.
Author information
1
Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and S. Raffaele Scientific Institute, 20132 Milan, Italy.
See:
https://pubpeer.com/publications/C0BDF85775B934DA967C62AA3ADC95#1
and
https://pubpeer.com/publications/C0BDF85775B934DA967C62AA3ADC95#3
Domenico Accili, co-author on first retraction.
Am J Physiol Endocrinol Metab. 2001 Jul;281(1):E16-24.
Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice.
https://www.physiology.org/doi/pdf/10.1152/ajpendo.2001.281.1.E16
LIAT SHEFI-FRIEDMAN,1 EFRAT WERTHEIMER,2 SHLOMZION SHEN,1
ASIA BAK,1 DOMENICO ACCILI,3 AND SANFORD R. SAMPSON1
1
Gonda-Goldschmeid Diagnostic Center, Faculty of Life Sciences, Bar-Ilan University,
Ramat-Gan 52900; 2
Department of Pathology, Sackler School of Medicine,
Tel-Aviv University, Ramat-Aviv 69978, Israel; and 3
Columbia University/
Berrie Research Pavilion, New York, New York 10032.
See: https://pubpeer.com/publications/03794BBA3451947D3AE2FF487D8D10#3
J Clin Invest. 2002 Jan;109(1):141-9.
Reduced expression of the murine p85α subunit
of phosphoinositide 3-kinase improves insulin
signaling and ameliorates diabetes.
https://dm5migu4zj3pb.cloudfront.net/manuscripts/13000/13305/cache/13305.1-20150302091719-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
Franck Mauvais-Jarvis,1 Kohjiro Ueki,1 David A. Fruman,2 Michael F. Hirshman,1
Kei Sakamoto,1 Laurie J. Goodyear,1 Matteo Iannacone,1 Domenico Accili,3
Lewis C. Cantley,2 and C. Ronald Kahn1
1Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston,
Massachusetts, USA
2Division of Signal Transduction, Beth Israel Deaconess Medical Center, Department of Cell Biology,
Harvard Medical School, Boston, Massachusetts, USA
3Diabetes Research Unit, Columbia University, New York, New York, USA
Address correspondence to: C. Ronald Kahn, Research Division, Joslin Diabetes Center,
One Joslin Place, Boston, Massachusetts 02215, USA.
See:
https://pubpeer.com/publications/4F5D020E7E7E7E3D5E5DB3F27BCD9E#25
https://academic.oup.com/jcem/article/85/5/2004/2660610
The Gly→Arg972 Amino Acid Polymorphism in Insulin Receptor Substrate-1 Affects Glucose Metabolism in Skeletal Muscle Cells*
Marta Letizia Hribal, Massimo Federici, Ottavia Porzio, Davide Lauro, Patrizia Borboni, Domenico Accili, Renato Lauro, Giorgio Sesti
The Journal of Clinical Endocrinology & Metabolism, Volume 85, Issue 5, 1 May 2000, Pages 2004–2013, https://doi.org/10.1210/jcem.85.5.6608
See: https://pubpeer.com/publications/D405F2FE38B5F4B23632EB73B7143C#1
https://pubpeer.com/publications/D405F2FE38B5F4B23632EB73B7143C#2
and
https://pubpeer.com/publications/D405F2FE38B5F4B23632EB73B7143C#3
Nat Med. 2011 Jul 31;17(8):961-7. doi: 10.1038/nm.2378.
10 comments on PubPeer (by: Unregistered Submission, Peer 1, Peer 2, Peer 4)
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
Pajvani UB1, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D.
Author information
1
Department of Medicine, Columbia University, New York, New York, USA.
See:
https://pubpeer.com/publications/FAEE00B43680A0C7D3F4A88FFD8152#2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283942/pdf/JCI0526052.pdf
J Clin Invest. 2005 Dec;115(12):3494-505.
Timp3 deficiency in insulin receptor–
haploinsufficient mice promotes diabetes and
vascular inflammation via increased TNF-α
Massimo Federici,1,2 Marta L. Hribal,2,3 Rossella Menghini,2 Hiroko Kanno,3 Valentina Marchetti,2
Ottavia Porzio,2,4 Susan W. Sunnarborg,5 Stefano Rizza,1,2 Matteo Serino,2 Veronica Cunsolo,4
Davide Lauro,1,2 Alessandro Mauriello,6 David S. Smookler,7 Paolo Sbraccia,1,2 Giorgio Sesti,8
David C. Lee,5 Rama Khokha,7 Domenico Accili,3 and Renato Lauro1,2
1Center for Atherosclerosis, “Policlinico Tor Vergata” University Hospital, Rome, Italy. 2Department of Internal Medicine, University of Rome “Tor Vergata,”
Rome, Italy. 3Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA. 4Clinical Biochemistry Unit,
Department of Laboratory Medicine, “Policlinico Tor Vergata” University Hospital, Rome, Italy. 5Department of Biochemistry and Biophysics and
University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. 6Department of Biopathology, University of Rome “Tor Vergata,” and “Policlinico Tor Vergata” University Hospital, Rome, Italy. 7Ontario Cancer Institute, Toronto, Ontario, Canada. 8Department of Clinical and Experimental Medicine, University of Catanzaro, Catanzaro, Italy.
See:
https://pubpeer.com/publications/9A406B0F695652D292CA1253932EF9#3
https://pubpeer.com/publications/9A406B0F695652D292CA1253932EF9#4
J Clin Invest. 2004 Jul;114(2):214-23.
Transgenic rescue of insulin receptor-deficient mice.
Okamoto H1, Nakae J, Kitamura T, Park BC, Dragatsis I, Accili D.
Author information
1
Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
See:
https://pubpeer.com/publications/BDFE38DF43BBA16FC197F0B5FD829F#3
Diabetes. 2006 May;55(5):1190-6.
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
Buteau J1, Spatz ML, Accili D.
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1
Department of Medicine, Naomi Berrie Diabetes Center, Columbia University Medical Center, Berrie Research Pavilion, 1150 St. Nicholas Ave., Room 238, New York, NY 10032, USA.
See:
https://pubpeer.com/publications/7404AC1F7CCDA9D5E1FF1CBAB99E58
J Cell Biol. 2003 Aug 18;162(4):535-41.
Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors.
Hribal ML1, Nakae J, Kitamura T, Shutter JR, Accili D.
Author information
1
Russ Berrie Research Pavilion, Rm. 238, 1150 St. Nicholas Avenue, New York, NY 10032, USA.
See:https://pubpeer.com/publications/EB390C389A67B95C97932C27CC8587#2
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J Clin Invest. 2006 Sep;116(9):2464-72. Epub 2006 Aug 10.
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.
Matsumoto M1, Han S, Kitamura T, Accili D.
Author information
1
Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA.
Figure 4H. Northern blot.
See: https://pubpeer.com/publications/7ED7E5FE800AF2F9F5E9BAC2BB5E93
PLoS One. 2013 Dec 9;8(12):e82099. doi: 10.1371/journal.pone.0082099. eCollection 2013.
Bisphenol-A impairs insulin action and up-regulates inflammatory pathways in human subcutaneous adipocytes and 3T3-L1 cells.
Valentino R1, D’Esposito V2, Passaretti F3, Liotti A3, Cabaro S2, Longo M2, Perruolo G1, Oriente F2, Beguinot F4, Formisano P4.
Author information
1
Istituto di Endocrinologia ed Oncologia Sperimentale (IEOS-CNR), Naples, Italy.
2
Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli “Federico II”, Naples, Italy.
3
Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli “Federico II”, Naples, Italy ; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Salerno, Italy.
4
Istituto di Endocrinologia ed Oncologia Sperimentale (IEOS-CNR), Naples, Italy ; Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli “Federico II”, Naples, Italy.
Figures 3C and 7C.
https://imgur.com/WbXKTzz