Alfredo Fusco, a researcher in Italy who has been under criminal investigation for scientific misconduct, has earned his ninth retraction.
Retraction number nine, by The Journal of Clinical Investigation, is for duplicating data from another publication — which has also faced questions on PubPeer about image manipulation, along with many other papers by Fusco.
The retraction note for “The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells” explains that the journal is pulling the paper even though the authors claim that they can reproduce the data:
At the request of the corresponding author, the JCI is retracting this manuscript. The corresponding author recently notified the JCI that multiple microscopy images in Figure 2B were previously published and were used to represent different samples in another publication by the corresponding author’s group (1). The authors have stated that experimental data produced ad hoc are consistent with those in the original publication; however, the paper is being retracted due to data duplication and misrepresentation in the original publication.
The 2005 paper has been cited 226 times, according to Thomson Reuters Web of Science.
That paper cited in the note, “The Oncogenic Activity of RET Point Mutants for Follicular Thyroid Cells May Account for the Occurrence of Papillary Thyroid Carcinoma in Patients Affected by Familial Medullary Thyroid Carcinoma,” was published in 2004 by The American Journal of Pathology. On PubPeer, commenters suggested that another figure in that paper resembles one from a previously published paper co-authored by Fusco, and some parts of a figure appear to be duplicated within the paper itself.
Fusco is an author on both papers, which share a few authors including the first and last authors: Rosa Marina Melillo and Massimo Santoro, both affiliated with the University of Naples. Fusco is also listed at the University of Naples. We’ve reached out to Fusco, Santoro (the corresponding author) and to the university for more information.
We’ve also contacted the editor of The American Journal of Pathology to see if the journal has looked into the paper mentioned in the retraction note.
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Clin Cancer Res. 2005 Nov 15;11(22):8019-27.
Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness.
Celetti A1, Testa D, Staibano S, Merolla F, Guarino V, Castellone MD, Iovine R, Mansueto G, Somma P, De Rosa G, Galli V, Melillo RM, Santoro M.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche/Dipartimento di Biologia e Patologia Cellulare e Molecolare, University of Naples Federico II, Italy.
https://pubpeer.com/publications/16299231
http://i.imgur.com/ED6zdza.jpg
Clin Cancer Res. 2000 Nov;6(11):4300-6.
FRA-1 expression in hyperplastic and neoplastic thyroid diseases.
Chiappetta G1, Tallini G, De Biasio MC, Pentimalli F, de Nigris F, Losito S, Fedele M, Battista S, Verde P, Santoro M, Fusco A.
Author information
1Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Naples, Italy.
https://pubpeer.com/publications/11106247
http://i.imgur.com/KXV68yX.jpg
J Clin Endocrinol Metab. 2011 May;96(5):E772-81. doi: 10.1210/jc.2010-1182. Epub 2011 Mar 9.
TWIST1 plays a pleiotropic role in determining the anaplastic thyroid cancer phenotype.
Salerno P1, Garcia-Rostan G, Piccinin S, Bencivenga TC, Di Maro G, Doglioni C, Basolo F, Maestro R, Fusco A, Santoro M, Salvatore G.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, 80131 Naples, Italy.
https://pubpeer.com/publications/21389145
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Oncogene. 2005 Sep 15;24(41):6303-13.
RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors.
De Falco V1, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M, Pelicci G, Santoro M, Melillo RM.
Author information
1Instituto di Endocrinologia ed Oncologia Sperimentale del CNR ‘G. Salvatore’, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Via S. Pansini 5, 80131 Naples, Italy.
http://i.imgur.com/0caT7im.jpg
Oncogene. 2005 Apr 28;24(19):3187-95.
The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.
Pera IL1, Iuliano R, Florio T, Susini C, Trapasso F, Santoro M, Chiariotti L, Schettini G, Viglietto G, Fusco A.
Author information
1Department of Experimental and Clinical Medicine, Medical School of Catanzaro, ‘Magna Graecia’ University of Catanzaro, 88100 Catanzaro, Italy.
https://pubpeer.com/publications/15735685
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Oncogene. 2004 Aug 5;23(35):5958-67.
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas.
Castellone MD1, Guarino V, De Falco V, Carlomagno F, Basolo F, Faviana P, Kruhoffer M, Orntoft T, Russell JP, Rothstein JL, Fusco A, Santoro M, Melillo RM.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, 80131 Naples, Italy.
https://pubpeer.com/publications/15184868
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Br J Cancer. 2004 Jan 12;90(1):270-7.
Highly selective toxic and proapoptotic effects of two dimeric ribonucleases on thyroid cancer cells compared to the effects of doxorubicin.
Spalletti-Cernia D1, Sorrentino R, Di Gaetano S, Piccoli R, Santoro M, D’Alessio G, Laccetti P, Vecchio G.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, via S. Pansini 5, 80131 Naples, Italy.
https://pubpeer.com/publications/14710239
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Cancer Res. 2003 Nov 1;63(21):7423-7.
Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2.
Pentimalli F1, Dentice M, Fedele M, Pierantoni GM, Cito L, Pallante P, Santoro M, Viglietto G, Dal Cin P, Fusco A.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, 80131 Naples, Italy.
https://pubpeer.com/publications/14612541
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Cancer Res. 2003 Feb 15;63(4):882-6.
An adenovirus carrying the rat protein tyrosine phosphatase eta suppresses the growth of human thyroid carcinoma cell lines in vitro and in vivo.
Iuliano R1, Trapasso F, Le Pera I, Schepis F, Samà I, Clodomiro A, Dumon KR, Santoro M, Chiariotti L, Viglietto G, Fusco A.
Author information
1Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia di Catanzaro, Università degli Studi di Catanzaro Magna Graecia, 88100 Catanzaro, Italy.
https://pubpeer.com/publications/12591742
http://i.imgur.com/3YfCkUM.jpg
Biochem Biophys Res Commun. 2002 Jan 25;290(3):942-7.
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.
Pierantoni GM1, Bulfone A, Pentimalli F, Fedele M, Iuliano R, Santoro M, Chiariotti L, Ballabio A, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli “Federico II,” Naples, 80131, Italy.
https://pubpeer.com/publications/11798164
http://i.imgur.com/wsVcocg.jpg
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Mol Cell Biol. 2002 Oct;22(20):7351-63.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.
Pelicci G1, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG.
Author information
1Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.
https://pubpeer.com/publications/12242309
http://i.imgur.com/PPx4gBY.jpg
Oncogene. 2002 May 9;21(20):3190-8.
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
Fedele M1, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, Parlow AF, Visone R, Pierantoni GM, Outwater E, Santoro M, Croce CM, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Federico II Università degli Studi di Napoli, via Pansini 5, 80131 Naples, Italy.
https://pubpeer.com/publications/12082634
http://i.imgur.com/0cOZLOZ.jpg
Oncogene. 2002 May 9;21(20):3190-8.
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
Fedele M1, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, Parlow AF, Visone R, Pierantoni GM, Outwater E, Santoro M, Croce CM, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Federico II Università degli Studi di Napoli, via Pansini 5, 80131 Naples, Italy.
https://pubpeer.com/publications/11788677
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J Clin Endocrinol Metab. 2002 Jan;87(1):370-9.
RET activation and clinicopathologic features in poorly differentiated thyroid tumors.
Santoro M1, Papotti M, Chiappetta G, Garcia-Rostan G, Volante M, Johnson C, Camp RL, Pentimalli F, Monaco C, Herrero A, Carcangiu ML, Fusco A, Tallini G.
Author information
1Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, 80131 Naples, Italy.
https://pubpeer.com/publications/11788678
http://i.imgur.com/PYXeraL.jpg
Cancer Res. 2001 Mar 1;61(5):2267-75.
Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation.
de Nigris F1, Mega T, Berger N, Barone MV, Santoro M, Viglietto G, Verde P, Fusco A.
Author information
1Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Naples, Italy.
https://pubpeer.com/publications/11280797
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Cancer Res. 2001 Jun 1;61(11):4583-90.
Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells.
Fedele M1, Pierantoni GM, Berlingieri MT, Battista S, Baldassarre G, Munshi N, Dentice M, Thanos D, Santoro M, Viglietto G, Fusco A.
Author information
1Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Patologia Cellulare e Molecolare, Università degli Studi di Napoli Federico II, via Pansini 5, 80131 Naples, Italy.
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Mol Cell Biol. 2001 Apr;21(7):2485-95.
Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation.
Melillo RM1, Pierantoni GM, Scala S, Battista S, Fedele M, Stella A, De Biasio MC, Chiappetta G, Fidanza V, Condorelli G, Santoro M, Croce CM, Viglietto G, Fusco A.
Author information
1Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologiae Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Italy.
http://i.imgur.com/YADslUS.jpg
Oncogene. 2001 Sep 27;20(43):6132-41.
High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth.
Pierantoni GM1, Fedele M, Pentimalli F, Benvenuto G, Pero R, Viglietto G, Santoro M, Chiariotti L, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
https://pubpeer.com/publications/11593421
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Mol Cell Biol. 2000 Dec;20(24):9236-46.
Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1).
Trapasso F1, Iuliano R, Boccia A, Stella A, Visconti R, Bruni P, Baldassarre G, Santoro M, Viglietto G, Fusco A.
Author information
1Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia di Catanzaro, Università degli Studi di Catanzaro “Magna Graecia,” 88100 Catanzaro,” 80131 Naples, Italy.
https://pubpeer.com/publications/11094075
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Exp Cell Res. 2000 Nov 1;260(2):257-67.
Pivotal role of the RB family proteins in in vitro thyroid cell transformation.
Iuliano R1, Trapasso F, Stella A, Le Pera I, Melillo RM, Bruni P, Baldassarre G, Chiariotti L, Santoro M, Viglietto G, Fusco A.
Author information
1Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Catanzaro “Magna Graecia,”, Catanzaro, 88100, Italy.
https://pubpeer.com/publications/11035920
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Cancer Res. 1999 Oct 1;59(19):4793-7.
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.
Battista S1, Fidanza V, Fedele M, Klein-Szanto AJ, Outwater E, Brunner H, Santoro M, Croce CM, Fusco A.
Author information
1Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.
https://pubpeer.com/publications/10519386
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Oncogene. 1998 May 14;16(19):2435-45.
Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.
Chiariello M1, Visconti R, Carlomagno F, Melillo RM, Bucci C, de Franciscis V, Fox GM, Jing S, Coso OA, Gutkind JS, Fusco A, Santoro M.
Author information
1Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università di Napoli Federico II, Naples, Italy.
https://pubpeer.com/publications/9627110
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Oncogene. 1998 Jul 23;17(3):377-85.
Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo.
Battista S1, de Nigris F, Fedele M, Chiappetta G, Scala S, Vallone D, Pierantoni GM, Mega T, Santoro M, Viglietto G, Verde P, Fusco A.
Author information
1Instituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Oncologia Sperimentale D ed E, Italia.
https://pubpeer.com/publications/9690519
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Exp Cell Res. 1997 Aug 25;235(1):62-70.
Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase.
Zhang L1, Martelli ML, Battaglia C, Trapasso F, Tramontano D, Viglietto G, Porcellini A, Santoro M, Fusco A.
Author information
1Facoltà di Medicina e Chirurgia di Catanzaro, Università degli Studi di Reggio Calabria, via Tommaso Campanella 5, Catanzaro, 88100, Italy.
https://pubpeer.com/publications/9281353
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Oncogene. 1997 Oct 16;15(16):1987-94.
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.
Visconti R1, Cerutti J, Battista S, Fedele M, Trapasso F, Zeki K, Miano MP, de Nigris F, Casalino L, Curcio F, Santoro M, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Italy.
https://pubpeer.com/publications/9365245
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Clin Cancer Res. 1996 Jan;2(1):119-26.
Block of c-myc expression by antisense oligonucleotides inhibits proliferation of human thyroid carcinoma cell lines.
Cerutti J1, Trapasso F, Battaglia C, Zhang L, Martelli ML, Visconti R, Berlingieri MT, Fagin JA, Santoro M, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli “Federico II,” via Pansini, 5, 80131 Napoli, Italy.
https://pubpeer.com/publications/9816098
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J Biol Chem. 1996 Nov 15;271(46):29497-501.
Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B.
Rizzo C1, Califano D, Colucci-D’Amato GL, De Vita G, D’Alessio A, Dathan NA, Fusco A, Monaco C, Santelli G, Vecchio G, Santoro M, de Franciscis V.
Author information
1Centro di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli “Federico II,” via S. Pansini 5, 80131 Napoli, Italy.
https://pubpeer.com/publications/8910618
http://i.imgur.com/CjcYFEc.jpg
Mol Cell Biol. 1995 Mar;15(3):1545-53.
Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells.
Berlingieri MT1, Manfioletti G, Santoro M, Bandiera A, Visconti R, Giancotti V, Fusco A.
Author information
1Centro di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Italy.
https://pubpeer.com/publications/7862147
http://i.imgur.com/dv9rFiC.jpg
Clin Cancer Res. 2006 Mar 1;12(5):1623-9.
BRAF is a therapeutic target in aggressive thyroid carcinoma.
Salvatore G1, De Falco V, Salerno P, Nappi TC, Pepe S, Troncone G, Carlomagno F, Melillo RM, Wilhelm SM, Santoro M.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Naples, Italy.
http://i.imgur.com/2jg8B79.jpg
http://i.imgur.com/wVBhyJL.png
http://i.imgur.com/VoZX0SZ.jpg
http://i.imgur.com/dOnRv9v.jpg
Cancer Res. 2006 Jun 15;66(12):6280-7.
The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.
Iervolino A1, Iuliano R, Trapasso F, Viglietto G, Melillo RM, Carlomagno F, Santoro M, Fusco A.
Author information
1Naples Oncogenomic Center-Centro di Ricerca per l’Ingegneria Genetica, Biotecnologie Avanzate, Italy.
http://i.imgur.com/n5tCc0Q.jpg
http://imgur.com/YCNyCq5
http://i.imgur.com/2QIJxxt.jpg
http://i.imgur.com/4470ANt.jpg
Endocr Relat Cancer. 2006 Jun;13(2):497-508.
MicroRNA deregulation in human thyroid papillary carcinomas.
Pallante P1, Visone R, Ferracin M, Ferraro A, Berlingieri MT, Troncone G, Chiappetta G, Liu CG, Santoro M, Negrini M, Croce CM, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, via Pansini, 5, 80131 Naples, Italy.
https://pubpeer.com/publications/16728577
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Eur J Endocrinol. 2006 Nov;155(5):645-53.
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
Santoro M1, Melillo RM, Fusco A.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR ‘G. Salvatore’, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University ‘Federico II’, Via S. Pansini, 5, 80131 Naples, Italy.
https://pubpeer.com/publications/17062879
Oncogene. 2007 Nov 29;26(54):7590-5. Epub 2007 Jun 11.
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
Visone R1, Pallante P, Vecchione A, Cirombella R, Ferracin M, Ferraro A, Volinia S, Coluzzi S, Leone V, Borbone E, Liu CG, Petrocca F, Troncone G, Calin GA, Scarpa A, Colato C, Tallini G, Santoro M, Croce CM, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli ‘Federico II’, Naples, Italy.
http://i.imgur.com/bVUZ6HJ.jpg
Figure 1a has been replaced in a 2016 correction.
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2016139a.html
The authors wish to replace Figure 1a with the following figure, which shows an alternative experiment. Representative ATC (anaplastic thyroid carcinoma) (n=6) and PTC (papillary thyroid carcinoma) (n=6). samples were analyzed for the expression of the miR-30d, miR-125b, miR-26a, miR30a-5p. As control, three normal thyroid samples were used. The results confirm the strong downregulation of the examined miRs in ATC but not in PTC samples. For this experiment, qRT-PCR analysis was performed in 6 papillary (PTC1-6) and 6 anaplastic (ATC1-6) thyroid carcinoma samples. cDNAs were generated by using miScript Kit (Qiagen, Valencia, CA, USA), and amplifications were performed by using miScript SYBR Green PCR Kit (Qiagen) and miScript Primer Assays for miR-30d, miR-125b, miR-26a, miR30a-5p and U6 for normalization (Qiagen). Reactions were performed in duplicate in a real-time CFX96 thermocycler (Bio-Rad, Hercules, CA, USA). The relative quantity of each microRNA was normalized to the U6 RNA amount by using the 2-DDCt formula and the values indicate relative expression levels in tumor samples±s.d. compared with average expression levels of three normal thyroid samples.
Endocr Relat Cancer. 2009 Jun;16(2):483-90. doi: 10.1677/ERC-08-0272. Epub 2009 Mar 4.
Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice.
Fedele M1, Palmieri D, Chiappetta G, Pasquinelli R, De Martino I, Arra C, Palma G, Valentino T, Pierantoni GM, Viglietto G, Rothstein JL, Santoro M, Fusco A.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, 80131 Naples, Italy.
https://pubpeer.com/publications/19261681
http://i.imgur.com/BiCgD6T.jpg
Oncogene. 2010 Jul 29;29(30):4341-51. doi: 10.1038/onc.2010.179. Epub 2010 May 24.
CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1.
Leone V1, Mansueto G, Pierantoni GM, Tornincasa M, Merolla F, Cerrato A, Santoro M, Grieco M, Scaloni A, Celetti A, Fusco A.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, Naples, Italy.
https://pubpeer.com/publications/20498639
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http://i.imgur.com/3MOsrP2.jpg
Mol Endocrinol. 2011 Oct;25(10):1819-30. doi: 10.1210/me.2011-0014. Epub 2011 Aug 4.
A TSH-CREB1-microRNA loop is required for thyroid cell growth.
Leone V1, D’Angelo D, Ferraro A, Pallante P, Rubio I, Santoro M, Croce CM, Fusco A.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, Naples, Italy.
https://pubpeer.com/publications/21816899
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J Pathol. 2011 May;224(1):110-20. doi: 10.1002/path.2846. Epub 2011 Mar 7.
Down-regulation of oestrogen receptor-β associates with transcriptional co-regulator PATZ1 delocalization in human testicular seminomas.
Esposito F1, Boscia F, Franco R, Tornincasa M, Fusco A, Kitazawa S, Looijenga LH, Chieffi P.
Author information
1Dipartimento di Medicina Sperimentale, II Università di Napoli, Naples, Italy.
https://pubpeer.com/publications/13955DF2DEE158B7C685A5468CBB93
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J Clin Endocrinol Metab. 2012 Jul;97(7):E1128-38. doi: 10.1210/jc.2011-3482. Epub 2012 May 7.
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.
D’Angelo D1, Palmieri D, Mussnich P, Roche M, Wierinckx A, Raverot G, Fedele M, Croce CM, Trouillas J, Fusco A.
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1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (CNR) c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita` degli Studi di Napoli, Napoli, Italy.
https://pubpeer.com/publications/22564666
http://i.imgur.com/59g6fAe.jpg
Mol Oncol. 2013 Jun;7(3):531-42. doi: 10.1016/j.molonc.2013.01.002. Epub 2013 Jan 17.
The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression.
Mussnich P1, D’Angelo D, Leone V, Croce CM, Fusco A.
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1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, Naples, Italy.
https://pubpeer.com/publications/23384558
http://i.imgur.com/ZyyhpTE.jpg
BMC Cancer. 2013 Sep 24;13:433. doi: 10.1186/1471-2407-13-433.
Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors.
Staibano S1, Ilardi G, Leone V, Luise C, Merolla F, Esposito F, Morra F, Siano M, Franco R, Fusco A, Chieffi P, Celetti A.
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1Istituto di Endocrinologia ed Oncologia Sperimentale, CNRz, via S Pansini, 5, Naples 80131, Italy.
https://pubpeer.com/publications/24059746
http://i.imgur.com/DHNutrW.jpg
http://i.imgur.com/XCMeiVf.jpg
Cancer Res. 2010 Jul 1;70(13):5379-88. doi: 10.1158/0008-5472.CAN-09-4199. Epub 2010 Jun 8.
High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene.
Esposito F1, Tornincasa M, Chieffi P, De Martino I, Pierantoni GM, Fusco A.
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1Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Università degli Studi di Napoli Federico II, Naples, Italy.
https://pubpeer.com/publications/20530667
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http://i.imgur.com/K4QRGtR.jpg
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BMC Biol. 2009 May 21;7:24. doi: 10.1186/1741-7007-7-24.
The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis.
Chiefari E1, Paonessa F, Iiritano S, Le Pera I, Palmieri D, Brunetti G, Lupo A, Colantuoni V, Foti D, Gulletta E, De Sarro G, Fusco A, Brunetti A.
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1Dipartimento di Medicina Sperimentale e Clinica G. Salvatore, Catanzaro, Italy.
http://i.imgur.com/oCC6gSF.jpg
We were aware of this mistake just after getting the paper published. And this was referred to the ed. Original actin is available.
No, it is publication, not a private thing. Please request a correction at the journal.
Cancer Res. 2009 Mar 1;69(5):1844-50. doi: 10.1158/0008-5472.CAN-08-4133. Epub 2009 Feb 17.
HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas.
De Martino I1, Visone R, Wierinckx A, Palmieri D, Ferraro A, Cappabianca P, Chiappetta G, Forzati F, Lombardi G, Colao A, Trouillas J, Fedele M, Fusco A.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Italy.
https://pubpeer.com/publications/19223528
http://i.imgur.com/UMPAh8F.jpg
J Pathol. 2008 May;215(1):39-47. doi: 10.1002/path.2323.
PATZ1 gene has a critical role in the spermatogenesis and testicular tumours.
Fedele M1, Franco R, Salvatore G, Paronetto MP, Barbagallo F, Pero R, Chiariotti L, Sette C, Tramontano D, Chieffi G, Fusco A, Chieffi P.
Author information
1IEOS, CNR and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli ‘Federico II, 80131 Naples, Italy.
https://pubpeer.com/publications/18241078
http://i.imgur.com/wKB8ehB.jpg
Endocr Relat Cancer. 2007 Jun;14(2):405-20.
Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer.
Chiappetta G1, De Marco C, Quintiero A, Califano D, Gherardi S, Malanga D, Scrima M, Montero-Conde C, Cito L, Monaco M, Motti ML, Pasquinelli R, Agosti V, Robledo M, Fusco A, Viglietto G.
Author information
1Laboratorio Oncologia Sperimentale III, Istituto Nazionale Tumori, via M. Semmola, 80131 Napoli, Italy.
https://pubpeer.com/publications/17639054
http://i.imgur.com/ApTcxqP.jpg
Endocr Relat Cancer. 2007 Sep;14(3):875-86.
The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.
De Martino I1, Visone R, Palmieri D, Cappabianca P, Chieffi P, Forzati F, Barbieri A, Kruhoffer M, Lombardi G, Fusco A, Fedele M.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, University of Naples Federico II, via Pansini 5, 80131 Naples, Italy.
https://pubpeer.com/publications/17914116
http://i.imgur.com/cu6OTUO.jpg
Oncogene. 2007 Sep 13;26(42):6167-75. Epub 2007 Apr 9.
Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage.
Merolla F1, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A.
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1Dipartimento di Biologia e Patologia Cellulare e Molecolare, University ‘Federico II’, Naples, Italy.
http://i.imgur.com/klwrqFk.jpg
http://i.imgur.com/yzyLi18.jpg
PLoS Genet. 2007 Jul;3(7):e110.
DNA damage, homology-directed repair, and DNA methylation.
Cuozzo C1, Porcellini A, Angrisano T, Morano A, Lee B, Di Pardo A, Messina S, Iuliano R, Fusco A, Santillo MR, Muller MT, Chiariotti L, Gottesman ME, Avvedimento EV.
Author information
1Dipartimento di Biologia e Patologia Molecolare e Cellulare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università Federico II, Naples, Italy.
https://pubpeer.com/publications/17616978
http://i.imgur.com/DJMfXcn.jpg
http://i.imgur.com/KEG64Z7.jpg
Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta.
Arena S1, Pattarozzi A, Massa A, Esteve JP, Iuliano R, Fusco A, Susini C, Florio T.
Author information
1Section of Pharmacology, Department of Oncology, Biology and Genetics, Univertsity of Genova 16132 Genova, Italy.
https://pubpeer.com/publications/17021051
http://i.imgur.com/XHXvdBQ.jpg
Cancer Res. 2006 Mar 1;66(5):2536-43.
Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.
Fedele M1, Fidanza V, Battista S, Pentimalli F, Klein-Szanto AJ, Visone R, De Martino I, Curcio A, Morisco C, Del Vecchio L, Baldassarre G, Arra C, Viglietto G, Indolfi C, Croce CM, Fusco A.
Author information
1Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Italy.
https://pubpeer.com/publications/16510570
http://i.imgur.com/Oig5qCF.jpg
http://i.imgur.com/mtDwmgD.jpg
Cell Div. 2006 Aug 17;1:17.
E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression.
Fedele M1, Pierantoni GM, Visone R, Fusco A.
Author information
1Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, via S, Pansini, 5 80131 Napoli, Italy.
https://pubpeer.com/publications/16914062
http://i.imgur.com/fFLbri1.jpg
Oncogene. 2005 Oct 13;24(45):6809-19.
HMGA1 protein expression sensitizes cells to cisplatin-induced cell death.
Baldassarre G1, Belletti B, Battista S, Nicoloso MS, Pentimalli F, Fedele M, Croce CM, Fusco A.
Author information
1Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA.
https://pubpeer.com/publications/16007157
http://i.imgur.com/w6IpISi.jpg
Cancer Res. 2004 Aug 15;64(16):5728-35.
Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation.
Martinez Hoyos J1, Fedele M, Battista S, Pentimalli F, Kruhoffer M, Arra C, Orntoft TF, Croce CM, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare e/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli “Federico II,” Naples, Italy.
https://pubpeer.com/publications/15313913
http://i.imgur.com/SBclzbm.jpg
FASEB J. 2003 Aug;17(11):1496-8. Epub 2003 Jun 17.
Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation.
Battista S1, Pentimalli F, Baldassarre G, Fedele M, Fidanza V, Croce CM, Fusco A.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, via Pansini 5, 80131 Naples, Italy.
https://pubpeer.com/publications/12824305
http://i.imgur.com/ltNDqZD.png
http://i.imgur.com/YJlOEMt.jpg
Biochem J. 2003 May 15;372(Pt 1):145-50.
High-mobility group A1 proteins are overexpressed in human leukaemias.
Pierantoni GM1, Agosti V, Fedele M, Bond H, Caliendo I, Chiappetta G, Lo Coco F, Pane F, Turco MC, Morrone G, Venuta S, Fusco A.
Author information
1Department of Biology and Molecular/Cellular Pathology, c/o CNR Center for Endocrinology and Experimental Oncology, Faculty of Medicine and Surgery, Federico II University of Naples, via S. Pansini 5, 80131 Naples, Italy.
https://pubpeer.com/publications/12573034
http://i.imgur.com/6h1JsON.jpg
Mol Cell Biol. 2003 Apr;23(7):2225-38.
Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.
Baldassarre G1, Battista S, Belletti B, Thakur S, Pentimalli F, Trapasso F, Fedele M, Pierantoni G, Croce CM, Fusco A.
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1Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.
https://pubpeer.com/publications/12640109
http://i.imgur.com/UtU1PJJ.jpg
Thyroid. 2002 Sep;12(9):765-72.
Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium.
Santelli G1, Bartoli PC, Giuliano A, Porcellini A, Mineo A, Barone MV, Busiello I, Trapasso F, Califano D, Fusco A.
Author information
1Oncologia Sperimentale E, Istituto Nazionale dei Tumori di Napoli, Fondazione G. Pascale, Napoli, Italy.
https://pubpeer.com/publications/12481941
http://i.imgur.com/LO360S9.jpg
J Biol Chem. 2002 Feb 1;277(5):3280-5. Epub 2001 Nov 21.
PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription.
Pero R1, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, Bruni CB, Chiariotti L.
Author information
1Centro di Endocrinologia ed Oncologia Sperimentale del CNR “G. Salvatore,” Dipartimento di Biologia e Patologia Cellulare e Molecolare, “L. Califano” Università degli Studi di Napoli “Federico II,” via S. Pansini, 5, 80131 Napoli, Italy.
https://pubpeer.com/publications/11719514
http://i.imgur.com/3AHPucb.jpg
http://i.imgur.com/3kfJjNh.jpg
J Biol Chem. 2012 May 25;287(22):18308-17. doi: 10.1074/jbc.M112.346270. Epub 2012 Apr 9.
POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation.
Pero R1, Palmieri D, Angrisano T, Valentino T, Federico A, Franco R, Lembo F, Klein-Szanto AJ, Del Vecchio L, Montanaro D, Keller S, Arra C, Papadopoulou V, Wagner SD, Croce CM, Fusco A, Chiariotti L, Fedele M.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II and Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
http://www.jbc.org/content/289/21/14966.short
Western blot images representing PATZ, BCL6, and tubulin in Fig. 6C did not accurately represent the experimental results. Different lanes were erroneously duplicated. Lane 3 of the PATZ panel was duplicated in lane 7; lane 4 of the PATZ panel was duplicated in lanes 5 and 6; lane 1 of the BCL6 panel was duplicated in lane 2; lane 4 of the tubulin panel was duplicated in lane 7; and lane 5 of the tubulin panel was duplicated in lane 6. The authors have provided an image from a replicate experiment. This correction does not affect the interpretation or conclusions of this work.
Cell Growth Differ. 2000 Oct;11(10):517-26.
Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27.
Baldassarre G1, Boccia A, Bruni P, Sandomenico C, Barone MV, Pepe S, Angrisano T, Belletti B, Motti ML, Fusco A, Viglietto G.
Author information
1Servizio Oncologia Sperimentale E, Istituto Nazionale Tumori, Naples, Italy.
https://pubpeer.com/publications/11063125
http://i.imgur.com/tCPTapA.jpg
http://i.imgur.com/41dNp0Y.jpg
J Clin Invest. 1999 Oct;104(7):865-74.
Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells.
Baldassarre G1, Belletti B, Bruni P, Boccia A, Trapasso F, Pentimalli F, Barone MV, Chiappetta G, Vento MT, Spiezia S, Fusco A, Viglietto G.
Author information
1Istituto Nazionale dei Tumori “Fondazione Senatore Pascale,” 80131 Naples, Italy.
https://pubpeer.com/publications/10510327
http://i.imgur.com/FDLF5nj.jpg
Mol Cell Biol. 1987 Sep;7(9):3365-70.
One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes.
Fusco A1, Berlingieri MT, Di Fiore PP, Portella G, Grieco M, Vecchio G.
Author information
1Dipartimento di Biologia e Patologia Cellulare e Molecolare, L. Califano II Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
https://pubpeer.com/publications/3670314
https://i.imgur.com/MGdjOVk.jpg
J Virol. 1985 Oct;56(1):284-92.
A mos oncogene-containing retrovirus, myeloproliferative sarcoma virus, transforms rat thyroid epithelial cells and irreversibly blocks their differentiation pattern.
Fusco A, Portella G, Di Fiore PP, Berlingieri MT, Di Lauro R, Schneider AB, Vecchio G.
https://pubpeer.com/publications/2993656
http://imgur.com/mUOqXva
Massimo Santoro is first author on this paper.
https://mcb.asm.org/content/mcb/16/12/7072.full.pdf
Mol Cell Biol. 1996 Dec;16(12):7072-83.
Constitutive activation of the RON gene promotes invasive growth but not transformation.
Santoro MM1, Collesi C, Grisendi S, Gaudino G, Comoglio PM.
Author information
1
Institute for Cancer Research, University of Turin Medical School, Italy.
See: https://pubpeer.com/publications/98703576DA83129585FD718DFFAE52