Archive for the ‘image manipulation’ Category
Pfizer has retracted a paper by a former employee who was fired after the company discovered she had been doctoring data.
The retraction, in Molecular Cancer Research, is the third of five papers Pfizer asked to retract, after an investigation discovered they contained duplicated images. The papers have been discussed on PubPeer, which is also mentioned in the latest retraction notice.
As a result of the investigation, Pfizer terminated the employment of Min-Jean Yin, the last author on the newly retracted paper.
According to the notice, Yin and five of her co-authors agreed to the retraction:
According to the retraction notice, Wayne State University found that Christian Kreipke had used several images in these articles “to represent different results in grant proposals and/or poster presentations,” and that the data were unreliable. Kreipke now has a total of five retractions, by our count.
As we’ve reported before, Wayne State and Kreipke have been engaged in conflict for several years. In 2012, Kreipke was dismissed from his assistant professor post at Wayne State after the university said it found evidence of research misconduct, according to Courthouse News. Kreipke fired back against the university, filing a whistleblower lawsuit. In it, Kreipke claimed that the institution was “involved in a conspiracy,” according to unsealed court documents, in which it had swindled the U.S. government out of millions in research funding.
A cancer biologist based at the University of Maryland is transitioning out of research, as a journal has retracted three more of his papers.
Anil Jaiswal has now lost 13 papers, including, as we reported on February 6, six retractions issued earlier this month.
The Baltimore Sun reported this week that Jaiswal would no longer be conducting research at the University of Maryland School of Medicine, which we confirmed from a spokesperson:
The notices keep coming for diabetes researcher Mario Saad.
Diabetes has just retracted two more of his papers, both of which had been flagged by expressions of concern, citing problems with duplications. What’s more, the journal added another expression of concern to a 2009 paper on which Saad — based at the University of Campinas in São Paulo, Brazil — is listed as last author, again over concerns of duplication.
This isn’t Saad’s first run-in with the journal: In 2015, the researcher sued the publisher, the American Diabetes Association, after it issued expressions of concern for four of his papers. Later that year, a judge dismissed Saad’s defamation suit. The journal eventually retracted the papers.
The latest articles flagged by Diabetes appear to be part of an intricate publishing web, as the journal suggests all papers have used features of previous papers, and also include elements that have been republished by subsequent articles.
A journal has retracted six papers by a cancer researcher at the University of Maryland in Baltimore, bringing his total to 10.
The retractions cite an investigation by the university, and detail problems ranging from duplicated images, to tweaking an image to conceal particular bands, to including unreliable data.
Three of the papers had already been flagged by the journal with expressions of concern. The last author on all the papers is Anil Jaiswal, a professor in the pharmacology department. He has issued four previous retractions.
Bruce Jarrell, the Chief Academic and Research Officer and Senior Vice President at the University of Maryland, told us at least two more retractions are forthcoming:
One paper published in 2012 was retracted — at the researcher’s request — for copying from a 2010 paper of his. In turn, both papers were duplicated in a paper that was published in 2016, and retracted a few months later. That 2016 paper borrowed from another paper published last year, which was quickly retracted after we contacted the journal.
These papers — by Dilip Kumar Das, listed at T. M. Bhagalpur University in India — were flagged in March by a PubPeer commenter.
In December, Plant Cell, Tissue and Organ Culture (PCTOC) retracted Das’s 2012 paper; here’s the retraction notice:
Researchers have retracted a biology paper that included an image mismatch — despite the fact that, as they claim, another image in the same paper confirms the original findings.
The authors say they plan to resubmit the paper with the corrected figure panel.
The second to last author — Carlo Croce, chair of the department of cancer biology and genetics at The Ohio State University — told us he believes there’s more to the retraction than what the notice says. Specifically, he said that the paper includes an image from a previous paper by the same authors, which he called “fraud.”
Here’s the latest retraction notice, published in Cell Death and Differentiation:
A researcher who claimed image problems in a retracted paper were the result of a software glitch, and not intentional, has lost three more papers — all for image manipulation.
In two notices, the Journal of Biological Chemistry specifies that duplicated images were used to represent different experimental conditions; one notice simply says the paper was affected by image manipulation.
All of the notices specify the papers are being retracted by the publisher, the American Society for Biochemistry and Molecular Biology — which this month published a set of recommendations for preparing a paper, including how to avoid excessive manipulation.
Here’s the first notice:
The former president of the Joslin Diabetes Center has withdrawn a second article within a month of his first, and issued extensive corrections to another paper in the same journal, all due to figure errors.
In November, we reported that Carl Ronald Kahn — also affiliated with Harvard Medical School — had pulled a highly cited 2005 paper from The Journal of Clinical Investigation because of image duplication issues, which Kahn told us were introduced during figure assembly. This December, Kahn retracted a 2003 paper published in The Journal of Biological Chemistry (JBC)—again due to duplication issues that the authors believe “were inadvertently introduced during figure assembly.”
Here’s the retraction notice for “Bi-directional regulation of brown fat adipogenesis by the insulin receptor,” cited 46 times, according to Clarivate Analytics’ Web of Science, formerly part of Thomson Reuters:
Last year, Pfizer fired one of its scientists following an investigation that ended with requests for retraction of five of her studies. Now, two of the five papers, which were first flagged on PubPeer, have been retracted.
One notice cites the Pfizer investigation, which found that cancer researcher Min-Jean Yin had included duplicated images in all five papers. Yin is the last author on both retracted papers.
Here’s the first notice from Clinical Cancer Research, which says most or all of the questioned images appear to be duplicates, and Pfizer — who sponsored the study and requested the retraction — can’t find the originals:
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